A Phase 3 Clinical Outcomes Study to Compare the Incidence of Major Adverse Cardiovascular Events in Subjects Presenting With Acute Coronary Syndrome Treated With Losmapimod Compared to Placebo (LATITUDE-TIMI 60)

PHASE3CompletedINTERVENTIONAL
Enrollment

3,503

Participants

Timeline

Start Date

June 3, 2014

Primary Completion Date

December 14, 2015

Study Completion Date

December 14, 2015

Conditions
Acute Coronary Syndrome
Interventions
DRUG

Losmapimod 7.5 mg twice daily

Subjects will receive Losmapimod 7.5 mg as film-coated, round, plain faced tablets.

DRUG

Placebo twice daily

Subjects will receive placebo as film-coated, round, plain faced tablets.

DRUG

Standard therapy

Subjects will receive standard therapy consistent with the appropriate guidelines from professional societies. The standard therapy includes nitrates, morphine sulfate, beta adrenergic blockers, renin-angiotensin aldosterone inhibitors, other anti-ischemic therapies, and analgesic therapy.

Trial Locations (341)

104

GSK Investigational Site, Taipei

112

GSK Investigational Site, Taipei

500

GSK Investigational Site, Changhua

813

GSK Investigational Site, Kaohsiung City

970

GSK Investigational Site, Hualien City

1000

GSK Investigational Site, Sofia

GSK Investigational Site, Manila

1030

GSK Investigational Site, Grafton, Auckland

1100

GSK Investigational Site, Quezon City

1122

GSK Investigational Site, Budapest

1134

GSK Investigational Site, Budapest

1407

GSK Investigational Site, Sofia

1500

GSK Investigational Site, San Juan City

1572

GSK Investigational Site, Sofia

1600

GSK Investigational Site, Pasig

1640

GSK Investigational Site, Otahuhu, Auckland

2193

GSK Investigational Site, Parktown West

2600

GSK Investigational Site, Venado Tuerto

2629

GSK Investigational Site, Lillehammer

2650

GSK Investigational Site, Hvidovre

2700

GSK Investigational Site, Blagoevgrad

2800

GSK Investigational Site, Mechelen

2820

GSK Investigational Site, Bonheiden

2930

GSK Investigational Site, Brasschaat

3000

GSK Investigational Site, Leuven

3076

GSK Investigational Site, Epping

3204

GSK Investigational Site, Hamilton

3220

GSK Investigational Site, Geelong

3600

GSK Investigational Site, Genk

4000

GSK Investigational Site, Liège

4011

GSK Investigational Site, Stavanger

4029

GSK Investigational Site, Herston

4032

GSK Investigational Site, Brisbane

4310

GSK Investigational Site, New Plymouth

4400

GSK Investigational Site, Pazardzhik

4560

GSK Investigational Site, Nambour

4870

GSK Investigational Site, Cairns

5004

GSK Investigational Site, Szolnok

5042

GSK Investigational Site, Bedford Park

5530

GSK Investigational Site, Yvoir

6009

GSK Investigational Site, Nedlands

6021

GSK Investigational Site, Wellington South

6150

GSK Investigational Site, Murdoch

6400

GSK Investigational Site, Dimitrovgrad

7000

GSK Investigational Site, Hobart

7130

GSK Investigational Site, Somerset West

7405

GSK Investigational Site, Pinelands

7505

GSK Investigational Site, Cape Town

7530

GSK Investigational Site, Bellville

7580

GSK Investigational Site, Kuils River

8000

GSK Investigational Site, Bruges

8011

GSK Investigational Site, Christchurch

8230

GSK Investigational Site, Balatonfüred

8900

GSK Investigational Site, Zalaegerszeg

9000

GSK Investigational Site, Ghent

9038

GSK Investigational Site, Tromsø

9300

GSK Investigational Site, Aalst

10138

GSK Investigational Site, Tallinn

10330

GSK Investigational Site, Bangkok

10400

GSK Investigational Site, Bangkok

10700

GSK Investigational Site, Bangkok

11794

GSK Investigational Site, Stony Brook

12208

GSK Investigational Site, Albany

12601

GSK Investigational Site, Poughkeepsie

13419

GSK Investigational Site, Tallinn

15706

GSK Investigational Site, Santiago de Compostela

16321

GSK Investigational Site, Bernau bei Berlin

17201

GSK Investigational Site, Chambersburg

17403

GSK Investigational Site, York

18009

GSK Investigational Site, Cherkassy

18702

GSK Investigational Site, Wilkes-Barre

18901

GSK Investigational Site, Doylestown

19001

GSK Investigational Site, Abington

20099

GSK Investigational Site, Hamburg

20138

GSK Investigational Site, Milan

20162

GSK Investigational Site, Milan

20246

GSK Investigational Site, Hamburg

21079

GSK Investigational Site, Dijon

22100

GSK Investigational Site, Nahariya

22291

GSK Investigational Site, Hamburg

24014

GSK Investigational Site, Roanoke

24127

GSK Investigational Site, Bergamo

25030

GSK Investigational Site, Besançon

26100

GSK Investigational Site, Cremona

26506

GSK Investigational Site, Morgantown

27401

GSK Investigational Site, Greensboro

27607

GSK Investigational Site, Raleigh

27610

GSK Investigational Site, Raleigh

28007

GSK Investigational Site, Madrid

28034

GSK Investigational Site, Madrid

28040

GSK Investigational Site, Marid

28046

GSK Investigational Site, Madrid

28204

GSK Investigational Site, Charlotte

28222

GSK Investigational Site, Majadahonda (Madrid)

29010

GSK Investigational Site, Málaga

29621

GSK Investigational Site, Anderson

30165

GSK Investigational Site, Rome

30625

GSK Investigational Site, Hanover

30901

GSK Investigational Site, Augusta

31059

GSK Investigational Site, Toulouse

32117

GSK Investigational Site, Daytona Beach

32207

GSK Investigational Site, Jacksonville

32209

GSK Investigational Site, Jacksonville

32250

GSK Investigational Site, Jacksonville Beach

32308

GSK Investigational Site, Tallahassee

32501

GSK Investigational Site, Pensacola

32960

GSK Investigational Site, Vero Beach

33100

GSK Investigational Site, Udine

33604

GSK Investigational Site, Bielefeld

33613

GSK Investigational Site, Tampa

34121

GSK Investigational Site, Kassel

34471

GSK Investigational Site, Ocala

35392

GSK Investigational Site, Giessen

35801

GSK Investigational Site, Huntsville

37203

GSK Investigational Site, Nashville

37205

GSK Investigational Site, Nashville

38100

GSK Investigational Site, Haddera

41063

GSK Investigational Site, Mönchengladbach

41071

GSK Investigational Site, Seville

42117

GSK Investigational Site, Wuppertal

43100

GSK Investigational Site, Parma

43701

GSK Investigational Site, Zanesville

44093

GSK Investigational Site, Nantes

44106

GSK Investigational Site, Cleveland

44137

GSK Investigational Site, Dortmund

44280

GSK Investigational Site, Guadalajara

44281

GSK Investigational Site, Kfar Saba

44710

GSK Investigational Site, Canton

44906

GSK Investigational Site, Mansfield

45215

GSK Investigational Site, Columbus

46237

GSK Investigational Site, Indianapolis

47303

GSK Investigational Site, Muncie

48085

GSK Investigational Site, Troy

48124

GSK Investigational Site, Dearborn

48197

GSK Investigational Site, Ypsilanti

48307

GSK Investigational Site, Rochester

48439

GSK Investigational Site, Grand Blanc

48960

GSK Investigational Site, Galdakano

49855

GSK Investigational Site, Marquette

50200

GSK Investigational Site, Chiang Mai

50266

GSK Investigational Site, West Des Moines

51014

GSK Investigational Site, Tartu

51375

GSK Investigational Site, Leverkusen

52074

GSK Investigational Site, Aachen

52240

GSK Investigational Site, Iowa City

53127

GSK Investigational Site, Bonn

54220

GSK Investigational Site, Manitowoc

54401

GSK Investigational Site, Wausau

55101

GSK Investigational Site, Saint Paul

55407

GSK Investigational Site, Minneapolis

55805

GSK Investigational Site, Duluth

56429

GSK Investigational Site, N. Efkarpia, Thessaloniki

57701

GSK Investigational Site, Rapid City

59208

GSK Investigational Site, Tourcoing

59322

GSK Investigational Site, Valenciennes

60126

GSK Investigational Site, Elmhurst

60504

GSK Investigational Site, Aurora

61018

GSK Investigational Site, Kharkiv

61231

GSK Investigational Site, Bad Nauheim

63110

GSK Investigational Site, St Louis

63225

GSK Investigational Site, Langen

64000

GSK Investigational Site, Pau

64114

GSK Investigational Site, Kansas City

64239

GSK Investigational Site, Tel Aviv

65804

GSK Investigational Site, Springfield

65929

GSK Investigational Site, Frankfurt am Main

67091

GSK Investigational Site, Strasbourg

68100

GSK Investigational Site, Alexandroupoli

68124

GSK Investigational Site, Omaha

68131

GSK Investigational Site, Omaha

68167

GSK Investigational Site, Mannheim

69000

GSK Investigational Site, Zaporizhzhya

70376

GSK Investigational Site, Stuttgart

70458

GSK Investigational Site, Slidell

70791

GSK Investigational Site, Zachary

70809

GSK Investigational Site, Baton Rouge

71301

GSK Investigational Site, Alexandria

72205

GSK Investigational Site, Little Rock

72401

GSK Investigational Site, Jonesboro

73135

GSK Investigational Site, Oklahoma City

73730

GSK Investigational Site, Esslingen am Neckar

75216

GSK Investigational Site, Dallas

75877

GSK Investigational Site, Paris

76000

GSK Investigational Site, Querétaro

76018

GSK Investigational Site, Ivano-Frankivsk

77901

GSK Investigational Site, Victoria

78240

GSK Investigational Site, San Luis Potosí City

78278

GSK Investigational Site, Ashkelon

78681

GSK Investigational Site, Round Rock

78756

GSK Investigational Site, Austin

79015

GSK Investigational Site, Lviv

79106

GSK Investigational Site, Freiburg im Breisgau

79189

GSK Investigational Site, Bad Krozingen

80120

GSK Investigational Site, Littleton

80204

GSK Investigational Site, Denver

82017

GSK Investigational Site, Montauban

83814

GSK Investigational Site, Coeur d'Alene

85713

GSK Investigational Site, Tucson

85724

GSK Investigational Site, Tucson

86326

GSK Investigational Site, Cottonwood

88014

GSK Investigational Site, Uzhhorod

90509

GSK Investigational Site, Torrance

90806

GSK Investigational Site, Long Beach

92161

GSK Investigational Site, San Diego

92648

GSK Investigational Site, Huntington Beach

92691

GSK Investigational Site, Mission Viejo

92868

GSK Investigational Site, Orange

93308

GSK Investigational Site, Bakersfield

93940

GSK Investigational Site, Monterey

98405

GSK Investigational Site, Tacoma

111539

GSK Investigational Site, Moscow

117292

GSK Investigational Site, Moscow

121374

GSK Investigational Site, Moscow

121552

GSK Investigational Site, Moscow

188300

GSK Investigational Site, Gatchina

190000

GSK Investigational Site, Saint Petersburg

192242

GSK Investigational Site, Saint Petersburg

199106

GSK Investigational Site, Saint Petersburg

200642

GSK Investigational Site, Craiova

390026

GSK Investigational Site, Ryazan

390039

GSK Investigational Site, Ryazan

410012

GSK Investigational Site, Saratov

410028

GSK Investigational Site, Saratov

443070

GSK Investigational Site, Samara

614107

GSK Investigational Site, Perm

625023

GSK Investigational Site, Tyumen

630008

GSK Investigational Site, Novosibirsk

634012

GSK Investigational Site, Tomsk

650002

GSK Investigational Site, Kemerovo

656055

GSK Investigational Site, Barnaul

664049

GSK Investigational Site, Irkutsk

4070038

GSK Investigational Site, Concepción

8207257

GSK Investigational Site, Santiago

8330024

GSK Investigational Site, Santiago

04210

GSK Investigational Site, Auburn

02115

GSK Investigational Site, Boston

08822

GSK Investigational Site, Flemington

07450

GSK Investigational Site, Ridgewood

07666

GSK Investigational Site, Teaneck

08043

GSK Investigational Site, Voorhees Township

17822-2160

GSK Investigational Site, Danville

37404-1173

GSK Investigational Site, Chattanooga

B1878DFK

GSK Investigational Site, Quilmes

S2000DSR

GSK Investigational Site, Rosario

C1428DCO

GSK Investigational Site, Buenos Aires

W3400AMZ

GSK Investigational Site, Corrientes

S3000AZG

GSK Investigational Site, Santa Fe

V3V 1Z2

GSK Investigational Site, Surrey

V5Z 1M9

GSK Investigational Site, Vancouver

V8R 4R2

GSK Investigational Site, Victoria

P3E5J1

GSK Investigational Site, Greater Sudbury

N2M 1B2

GSK Investigational Site, Kitchener

M1E 5E9

GSK Investigational Site, Scarborough Village

P7B 6V4

GSK Investigational Site, Thunder Bay

H1T 1C8

GSK Investigational Site, Montreal

J1H 5N4

GSK Investigational Site, Sherbrooke

Unknown

GSK Investigational Site, Temuco

GSK Investigational Site, Chai Wan

GSK Investigational Site, Kowloon

GSK Investigational Site, Shatin, New Territories

625 00

GSK Investigational Site, Brno

370 01

GSK Investigational Site, České Budějovice

500 05

GSK Investigational Site, Hradec Králové

460 63

GSK Investigational Site, Liberec

708 52

GSK Investigational Site, Ostrava

523 03

GSK Investigational Site, Pardubice

101 00

GSK Investigational Site, Prague

128 08

GSK Investigational Site, Prague

169 02

GSK Investigational Site, Prague

401 13

GSK Investigational Site, Ústí nad Labem

762 75

GSK Investigational Site, Zlín

DK-2900

GSK Investigational Site, Hellerup

DK-2400

GSK Investigational Site, København NV

DK-2300

GSK Investigational Site, København S

04103

GSK Investigational Site, Leipzig

04289

GSK Investigational Site, Leipzig

115 26

GSK Investigational Site, Athens

115 28

GSK Investigational Site, Athens

341 00

GSK Investigational Site, Chalcis

570 10

GSK Investigational Site, Thessaloniki

06156

GSK Investigational Site, Perugia

1815 JD

GSK Investigational Site, Alkmaar

3813 TZ

GSK Investigational Site, Amersfoort

1091 AC

GSK Investigational Site, Amsterdam

2625 AD

GSK Investigational Site, Delft

7416 SE

GSK Investigational Site, Deventer

5707 HA

GSK Investigational Site, Helmond

3435 CM

GSK Investigational Site, Nieuwegein

6532 SZ

GSK Investigational Site, Nijmegen

3045 PM

GSK Investigational Site, Rotterdam

3118 JH

GSK Investigational Site, Schiedam

6162 BG

GSK Investigational Site, Sittard-geleen

5042 AD

GSK Investigational Site, Tilburg

5912 BL

GSK Investigational Site, Venlo

8025 AB

GSK Investigational Site, Zwolle

0407

GSK Investigational Site, Oslo

N-3710

GSK Investigational Site, Skien

85-094

GSK Investigational Site, Bydgoszcz

80-952

GSK Investigational Site, Gdansk

81-348

GSK Investigational Site, Gdynia

88-100

GSK Investigational Site, Inowrocław

31-202

GSK Investigational Site, Krakow

59-301

GSK Investigational Site, Lubin

20-954

GSK Investigational Site, Lublin

10-561

GSK Investigational Site, Olsztyn

87-100

GSK Investigational Site, Torun

04-073

GSK Investigational Site, Warsaw

58-309

GSK Investigational Site, Wałbrzych

50-556

GSK Investigational Site, Wroclaw

014461

GSK Investigational Site, Bucharest

050098

GSK Investigational Site, Bucharest

833 48

GSK Investigational Site, Bratislava

040 11

GSK Investigational Site, Košice

036 59

GSK Investigational Site, Martin

949 01

GSK Investigational Site, Nitra

301-721

GSK Investigational Site, Daejeon

220-701

GSK Investigational Site, Ganwon-do

501-757

GSK Investigational Site, Gwangju

110-774

GSK Investigational Site, Seoul

134-727

GSK Investigational Site, Seoul

135-720

GSK Investigational Site, Seoul

137-701

GSK Investigational Site, Seoul

152-703

GSK Investigational Site, Seoul

08035

GSK Investigational Site, Barcelona

08036

GSK Investigational Site, Barcelona

08907

GSK Investigational Site, Barcelona

SE-413 45

GSK Investigational Site, Gothenburg

SE-416 85

GSK Investigational Site, Gothenburg

SE-251 87

GSK Investigational Site, Helsingborg

SE-551 85

GSK Investigational Site, Jönköping

SE-701 85

GSK Investigational Site, Örebro

SE-831 83

GSK Investigational Site, Östersund

SE-118 83

GSK Investigational Site, Stockholm

SE-721 89

GSK Investigational Site, Västerås

03680

GSK Investigational Site, Kyiv

RG24 9NA

GSK Investigational Site, Basingstoke

BH7 7DW

GSK Investigational Site, Bournemouth

DD1 9SY

GSK Investigational Site, Dundee

EH16 4SA

GSK Investigational Site, Edinburgh

NE7 7DN

GSK Investigational Site, Newcastle upon Tyne

YO31 8HE

GSK Investigational Site, York

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

The TIMI Study Group

OTHER

lead

GlaxoSmithKline

INDUSTRY

NCT02145468 - A Phase 3 Clinical Outcomes Study to Compare the Incidence of Major Adverse Cardiovascular Events in Subjects Presenting With Acute Coronary Syndrome Treated With Losmapimod Compared to Placebo (LATITUDE-TIMI 60) | Biotech Hunter | Biotech Hunter