Blinatumomab and Combination Chemotherapy or Dasatinib, Prednisone, and Blinatumomab in Treating Older Patients With Acute Lymphoblastic Leukemia

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

53

Participants

Timeline

Start Date

June 30, 2015

Primary Completion Date

June 1, 2022

Study Completion Date

June 24, 2026

Conditions
Acute Lymphoblastic LeukemiaB Acute Lymphoblastic LeukemiaB Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1Recurrent Acute Lymphoblastic LeukemiaRefractory Acute Lymphoblastic Leukemia
Interventions
PROCEDURE

Biopsy Procedure

Undergo a biopsy

PROCEDURE

Biospecimen Collection

Undergo a blood sample collection

BIOLOGICAL

Blinatumomab

Given IV

PROCEDURE

Bone Marrow Aspiration and Biopsy

Undergo a bone marrow aspiration and biopsy

PROCEDURE

Computed Tomography

Undergo a CT scan

DRUG

Dasatinib

Given PO

PROCEDURE

Echocardiography Test

Undergo ECHO

PROCEDURE

Lumbar Puncture

Undergo a lumbar puncture

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

DRUG

Mercaptopurine

Given PO

DRUG

Methotrexate

Given PO

DRUG

Methotrexate Sodium

Given PO

DRUG

Prednisone

Given PO

DRUG

Vincristine

Given IV

DRUG

Vincristine Sulfate

Given IV

PROCEDURE

X-Ray Imaging

Undergo an x-ray

Trial Locations (196)

11030

North Shore University Hospital, Manhasset

11040

Long Island Jewish Medical Center, New Hyde Park

11042

Northwell Health/Center for Advanced Medicine, Lake Success

14263

Roswell Park Cancer Institute, Buffalo

14642

University of Rochester, Rochester

19104

University of Pennsylvania/Abramson Cancer Center, Philadelphia

19107

Thomas Jefferson University Hospital, Philadelphia

21201

University of Maryland/Greenebaum Cancer Center, Baltimore

27157

Wake Forest University Health Sciences, Winston-Salem

27710

Duke University Medical Center, Durham

28349

ECU Health Oncology Kenansville, Kenansville

28501

ECU Health Oncology Kinston, Kinston

28574

ECU Health Oncology Richlands, Richlands

29316

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29601

Greenville Health System Cancer Institute-Andrews, Greenville

29605

Prisma Health Cancer Institute - Butternut, Greenville

Prisma Health Cancer Institute - Faris, Greenville

Prisma Health Greenville Memorial Hospital, Greenville

29615

Prisma Health Cancer Institute - Eastside, Greenville

29640

Prisma Health Cancer Institute - Easley, Easley

29650

Prisma Health Cancer Institute - Greer, Greer

29672

Prisma Health Cancer Institute - Seneca, Seneca

30342

Northside Hospital, Atlanta

30912

Augusta University Medical Center, Augusta

32806

Orlando Health Cancer Institute, Orlando

35233

University of Alabama at Birmingham Cancer Center, Birmingham

39216

University of Mississippi Medical Center, Jackson

41017

Oncology Hematology Care Inc-Crestview, Crestview Hills

43210

Ohio State University Comprehensive Cancer Center, Columbus

43537

Toledo Clinic Cancer Centers-Maumee, Maumee

Toledo Radiation Oncology at Northwest Ohio Onocolgy Center, Maumee

43616

Saint Charles Hospital, Oregon

43623

Mercy Health - Saint Anne Hospital, Toledo

Toledo Clinic Cancer Centers-Toledo, Toledo

44106

Case Western Reserve University, Cleveland

44195

Cleveland Clinic Foundation, Cleveland

45014

Oncology Hematology Care Inc-Healthplex, Fairfield

45202

Oncology Hematology Care Inc-Eden Park, Cincinnati

45211

Oncology Hematology Care Inc-Mercy West, Cincinnati

45230

Oncology Hematology Care Inc-Anderson, Cincinnati

45236

Oncology Hematology Care Inc-Kenwood, Cincinnati

45242

Oncology Hematology Care Inc-Blue Ash, Cincinnati

45331

Wayne Hospital, Greenville

45373

Upper Valley Medical Center, Troy

45406

Good Samaritan Hospital - Dayton, Dayton

45409

Miami Valley Hospital, Dayton

45415

Miami Valley Hospital North, Dayton

45429

Kettering Medical Center, Kettering

45433

Wright-Patterson Medical Center, Wright-Patterson Air Force Base

45459

Miami Valley Hospital South, Centerville

45504

Springfield Regional Cancer Center, Springfield

Springfield Regional Medical Center, Springfield

45840

Blanchard Valley Hospital, Findlay

46237

Franciscan Health Indianapolis, Indianapolis

46360

Franciscan Saint Anthony Health-Michigan City, Michigan City

Woodland Cancer Care Center, Michigan City

47374

Reid Health, Richmond

48073

Corewell Health William Beaumont University Hospital, Royal Oak

48085

Corewell Health Beaumont Troy Hospital, Troy

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48162

Toledo Clinic Cancer Centers-Monroe, Monroe

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48230

William Beaumont Hospital-Grosse Pointe, Grosse Pointe

48334

Weisberg Cancer Treatment Center, Farmington Hills

48336

Corewell Health Farmington Hills Hospital, Farmington Hills

49007

Bronson Methodist Hospital, Kalamazoo

West Michigan Cancer Center, Kalamazoo

49017

Bronson Battle Creek, Battle Creek

49048

Beacon Kalamazoo, Kalamazoo

49085

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph

Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph

49120

Corewell Health Lakeland Hospitals - Niles Hospital, Niles

49221

Hickman Cancer Center, Adrian

49444

Trinity Health Muskegon Hospital, Muskegon

49503

Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids

Trinity Health Grand Rapids Hospital, Grand Rapids

49677

Corewell Health Reed City Hospital, Reed City

49684

Munson Medical Center, Traverse City

50010

McFarland Clinic - Ames, Ames

50036

McFarland Clinic - Boone, Boone

50129

McFarland Clinic - Jefferson, Jefferson

50158

McFarland Clinic - Marshalltown, Marshalltown

50501

McFarland Clinic - Trinity Cancer Center, Fort Dodge

51101

Siouxland Regional Cancer Center, Sioux City

53226

Medical College of Wisconsin, Milwaukee

54301

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

55905

Mayo Clinic in Rochester, Rochester

56601

Sanford Joe Lueken Cancer Center, Bemidji

58122

Sanford Broadway Medical Center, Fargo

Sanford Roger Maris Cancer Center, Fargo

58501

Sanford Bismarck Medical Center, Bismarck

60451

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60504

Rush-Copley Medical Center, Aurora

60560

Rush-Copley Healthcare Center, Yorkville

60612

University of Illinois, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

Radiation Oncology of Northern Illinois, Ottawa

61354

Illinois CancerCare-Peru, Peru

Valley Radiation Oncology, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

Western Illinois Cancer Treatment Center, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

OSF Saint Francis Radiation Oncology at Pekin, Pekin

61615

Illinois CancerCare-Peoria, Peoria

OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61637

OSF Saint Francis Medical Center, Peoria

61701

OSF Saint Joseph Medical Center, Bloomington

61704

Illinois CancerCare-Bloomington, Bloomington

61801

Carle Cancer Center, Urbana

The Carle Foundation Hospital, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

Cancer Care Center of O'Fallon, O'Fallon

62321

Illinois CancerCare-Carthage, Carthage

62401

Carle Physician Group-Effingham, Effingham

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Central Illinois Hematology Oncology Center, Springfield

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Springfield Memorial Hospital, Springfield

62801

Centralia Oncology Clinic, Centralia

62864

SSM Health Good Samaritan, Mount Vernon

62902

Memorial Hospital of Carbondale, Carbondale

63080

Missouri Baptist Sullivan Hospital, Sullivan

63109

Mercy Infusion Center - Chippewa, St Louis

63127

BJC Outpatient Center at Sunset Hills, Sunset Hills

63131

Missouri Baptist Medical Center, St Louis

63141

Mercy Hospital Saint Louis, St Louis

63628

Parkland Health Center-Bonne Terre, Bonne Terre

63670

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

Mercy Cancer Center - Cape Girardeau, Cape Girardeau

Saint Francis Medical Center, Cape Girardeau

64804

Freeman Health System, Joplin

Mercy Hospital Joplin, Joplin

65109

MU Health Care Goldschmidt Cancer Center, Jefferson City

65401

Mercy Clinic-Rolla-Cancer and Hematology, Rolla

Phelps Health Delbert Day Cancer Institute, Rolla

65613

Central Care Cancer Center - Bolivar, Bolivar

65616

Cox Cancer Center Branson, Branson

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

66044

Lawrence Memorial Hospital, Lawrence

66160

University of Kansas Cancer Center, Kansas City

66205

University of Kansas Hospital-Westwood Cancer Center, Westwood

66701

Cancer Center of Kansas - Fort Scott, Fort Scott

66720

Cancer Center of Kansas - Chanute, Chanute

67042

Cancer Center of Kansas - El Dorado, El Dorado

67068

Cancer Center of Kansas-Kingman, Kingman

67114

Cancer Center of Kansas - Newton, Newton

67124

Cancer Center of Kansas - Pratt, Pratt

67152

Cancer Center of Kansas - Wellington, Wellington

67156

Cancer Center of Kansas - Winfield, Winfield

67208

Associates In Womens Health, Wichita

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita

67214

Ascension Via Christi Hospitals Wichita, Wichita

Cancer Center of Kansas - Wichita, Wichita

Wesley Medical Center, Wichita

67301

Cancer Center of Kansas-Independence, Independence

67357

Cancer Center of Kansas - Parsons, Parsons

67401

Cancer Center of Kansas - Salina, Salina

67460

Cancer Center of Kansas - McPherson, McPherson

67801

Cancer Center of Kansas - Dodge City, Dodge City

67905

Cancer Center of Kansas-Liberal, Liberal

68118

Nebraska Medicine-Village Pointe, Omaha

68123

Nebraska Medicine-Bellevue, Bellevue

68198

University of Nebraska Medical Center, Omaha

71103

LSU Health Sciences Center at Shreveport, Shreveport

72205

John L McClellan Memorial Veterans Hospital, Little Rock

73104

University of Oklahoma Health Sciences Center, Oklahoma City

75246

Baylor University Medical Center, Dallas

85719

Banner University Medical Center - Tucson, Tucson

University of Arizona Cancer Center-North Campus, Tucson

87106

University of New Mexico Cancer Center, Albuquerque

90033

Los Angeles General Medical Center, Los Angeles

USC / Norris Comprehensive Cancer Center, Los Angeles

91010

City of Hope Comprehensive Cancer Center, Duarte

91105

Keck Medical Center of USC Pasadena, Pasadena

92093

UC San Diego Moores Cancer Center, La Jolla

92354

Loma Linda University Medical Center, Loma Linda

92663

USC Norris Oncology/Hematology-Newport Beach, Newport Beach

92868

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

06510

Smilow Cancer Center/Yale-New Haven Hospital, New Haven

06520

Yale University, New Haven

45005-1066

Atrium Medical Center-Middletown Regional Hospital, Franklin

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH