Benralizumab Efficacy in Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) With Exacerbation History

PHASE3CompletedINTERVENTIONAL
Enrollment

1,656

Participants

Timeline

Start Date

June 13, 2014

Primary Completion Date

April 10, 2018

Study Completion Date

April 10, 2018

Conditions
Moderate to Very Severe Chronic Obstructive Pulmonary Disease
Interventions
DRUG

Benralizumab Arm A

Benralizumab subcutaneously on study week 0 until study week 48 inclusive

DRUG

Benralizumab Arm B

Benralizumab subcutaneously on study week 0 until study week 48 inclusive

DRUG

Placebo

Placebo subcutaneously on study week 0 until study week 48 inclusive

Trial Locations (407)

1055

Research Site, Middelburg

1135

Research Site, Budapest

1140

Research Site, Vienna

1204

Research Site, Budapest

2100

Research Site, Gödöllő

2193

Research Site, Gauteng

2440

Research Site, Százhalombatta

2502

Research Site, Biel

2660

Research Site, Balassagyarmat

3000

Research Site, Hatvan

3233

Research Site, Mátraháza

3529

Research Site, Miskolc

3780

Research Site, Edelény

4001

Research Site, Durban

4020

Research Site, Linz

4031

Research Site, Basel

4080

Research Site, Hajdúnánás

4126

Research Site, eManzimtoti

4600

Research Site, Wels

5020

Research Site, Salzburg

6020

Research Site, Innsbruck

6800

Research Site, Feldkirch

7626

Research Site, Pécs

7635

Research Site, Pécs

7764

Research Site, Cape Town

8000

Research Site, Székesfehérvár

8036

Research Site, Graz

8582

Research Site, Farkasgyepü

9007

Research Site, Sankt Gallen

9301

Research Site, Bloemfontein

10022

Research Site, New York

10036

Research Site, New York

10043

Research Site, Orbassano

10708

Research Site, Bronxville

10787

Research Site, Berlin

11229

Research Site, Brooklyn

13066

Research Site, Fayetteville

13187

Research Site, Berlin

14215

Research Site, Buffalo

14584

Research Site, Bucheon-si

15025

Research Site, Jefferson Hills

15213

Research Site, Pittsburgh

16132

Research Site, Genova

16508

Research Site, Erie

16602

Research Site, Altoona

19140

Research Site, Philadelphia

19610

Research Site, Wyomissing

20354

Research Site, Hamburg

21044

Research Site, Columbia

21049

Research Site, Tradate

21201

Research Site, Baltimore

21224

Research Site, Baltimore

21502

Research Site, Geesthacht

23219

Research Site, Richmond

23220

Research Site, Richmond

23225

Research Site, Richmond

23229

Research Site, Richmond

26426

Research Site, Wŏnju

27030

Research Site, Mount Airy

27100

Research Site, Pavia

27103

Research Site, Winston-Salem

27104

Research Site, Winston-Salem

27401

Research Site, Greensboro

27705

Research Site, Durham

27909

Research Site, Elizabeth City

28040

Research Site, Madrid

28054

Research Site, Gastonia

28207

Research Site, Charlotte

28401

Research Site, Wilmington

28562

Research Site, New Bern

28801

Research Site, Asheville

29010

Research Site, Málaga

29201

Research Site, Columbia

29303

Research Site, Spartanburg

29340

Research Site, Gaffney

29406

Research Site, Charleston

29464

Research Site, Mt. Pleasant

29615

Research Site, Greenville

29707

Research Site, Old Point Station

29732

Research Site, Rock Hill

30033

Research Site, Decatur

30060

Research Site, Marietta

30096

Research Site, Duluth

30342

Research Site, Atlanta

30701

Research Site, Calhoun

32129

Research Site, Port Orange

32405

Research Site, Panama City

32608

Research Site, Gainesville

32803

Research Site, Orlando

32819

Research Site, Orlando

32825

Research Site, Orlando

32960

Research Site, Vero Beach

33012

Research Site, Hialeah

33015

Research Site, Miami

33126

Research Site, Miami

33144

Research Site, Miami

33155

Research Site, Miami

33166

Research Site, Miami Springs

33316

Research Site, Fort Lauderdale

33435

Research Site, Boynton Beach

33470

Research Site, Loxahatchee Groves

33511

Research Site, Brandon

33707

Research Site, St. Petersburg

33713

Research Site, St. Petersburg

33756

Research Site, Clearwater

33765

Research Site, Clearwater

33870

Research Site, Sebring

34741

Research Site, Kissimmee

35043

Research Site, Marburg

35243

Research Site, Birmingham

35294

Research Site, Birmingham

35501

Research Site, Jasper

36305

Research Site, Dothan

36420

Research Site, Andalusia

37067

Research Site, Franklin

37075

Research Site, Hendersonville

37404

Research Site, Chattanooga

39008

Research Site, Santander

39100

Research Site, Bolzano

41017

Research Site, Fort Mitchell

41701

Research Site, Hazard

42415

Research Site, Daegu

43100

Research Site, Parma

44100

Research Site, Ferrara

44718

Research Site, Canton

45220

Research Site, Cincinnati

45231

Research Site, Cincinnati

45242

Research Site, Cincinnati

45459

Research Site, Dayton

46015

Research Site, Valencia

46360

Research Site, Michigan City

46383

Research Site, Valparaiso

48307

Research Site, Rochester

48336

Research Site, Farmington Hills

52242

Research Site, Iowa City

53123

Research Site, Bonn

55407

Research Site, Minneapolis

56124

Research Site, Pisa

57702

Research Site, Rapid City

58452

Research Site, Witten

60201

Research Site, Evanston

60389

Research Site, Frankfurt am Main

60506

Research Site, Aurora

60596

Research Site, Frankfurt

Research Site, Frankfurt am Main

60602

Research Site, Chicago

63110

Research Site, Rodgau-Dudenhofen

63143

Research Site, St Louis

63263

Research Site, Neu-Isenburg

63301

Research Site, Saint Charles

71593

Research Site, Bucharest

72209

Research Site, Little Rock

73103

Research Site, Oklahoma City

73112

Research Site, Oklahoma City

73116

Research Site, Oklahoma City

75034

Research Site, Frisco

75708

Research Site, Tyler

76012

Research Site, Arlington

77077

Research Site, Houston

77081

Research Site, Houston

77084

Research Site, Houston

77555

Research Site, Galveston

78006

Research Site, Boerne

78215

Research Site, San Antonio

78229

Research Site, San Antonio

78504

Research Site, McAllen

78704

Research Site, Austin

83616

Research Site, Eagle

84047

Research Site, Midvale

84604

Research Site, Provo

87108

Research Site, Albuquerque

89123

Research Site, Las Vegas

90146

Research Site, Palermo

90212

Research Site, Beverly Hills

90502

Research Site, Torrance

90717

Research Site, Lomita

90805

Research Site, Lakewood

91360

Research Site, Thousand Oaks

92103

Research Site, San Diego

92260

Research Site, Palm Desert

92506

Research Site, Riverside

92647

Research Site, Huntington Beach

92663

Research Site, Newport Beach

92704

Research Site, Santa Ana

94304

Research Site, Palo Alto

95123

Research Site, Catania

95670

Research Site, Gold River

95817

Research Site, Sacramento

96049

Research Site, Bamberg

97239

Research Site, Portland

97504

Research Site, Medford

97701

Research Site, Bend

99352

Research Site, Richland

109240

Research Site, Moscow

117593

Research Site, Moscow

121309

Research Site, Moscow

127018

Research Site, Moscow

127473

Research Site, Moscow

153005

Research Site, Ivanovo

180007

Research Site, Pskov

193312

Research Site, Saint Petersburg

194354

Research Site, Saint Petersburg

196084

Research Site, Saint Petersburg

196247

Research Site, Saint Petersburg

197089

Research Site, Saint Petersburg

197342

Research Site, Saint Petersburg

214019

Research Site, Smolensk

300310

Research Site, Timișoara

330061

Research Site, Deva

357500

Research Site, Pyatigorsk

362007

Research Site, Vladikavkaz

390026

Research Site, Ryazan

400001

Research Site, Volgograd

400131

Research Site, Volgograd

410012

Research Site, Saratov

420012

Research Site, Kazan'

426035

Research Site, Izhevsk

432009

Research Site, Ulyanovsk

440067

Research Site, Penza

450071

Research Site, Ufa

454021

Research Site, Chelyabinsk

500283

Research Site, Brasov

600023

Research Site, Vladimir

603126

Research Site, Nizhny Novgorod

614068

Research Site, Perm

620039

Research Site, Yekaterinburg

620109

Research Site, Yekaterinburg

620137

Research Site, Yekaterinburg

620219

Research Site, Yekaterinburg

630008

Research Site, Novosibirsk

630051

Research Site, Novosibirsk

630084

Research Site, Novosibirsk

634050

Research Site, Tomsk

634063

Research Site, Tomsk

650000

Research Site, Kemerovo

650002

Research Site, Kemerovo

650066

Research Site, Kemerovo

700115

Research Site, Iași

900002

Research Site, Constanța

90255-6046

Research Site, Huntington Park

06520-8057

Research Site, New Haven

06708

Research Site, Waterbury

32789-4681

Research Site, Winter Park

02747

Research Site, North Dartmouth

07901

Research Site, Summit

T2N 4Z6

Research Site, Calgary

T2Y 2Z7

Research Site, Calgary

T8L 0N2

Research Site, Sherwood Park

V5Z 1M9

Research Site, Vancouver

V6Z 1Y6

Research Site, Vancouver

L1Z 0M1

Research Site, Ajax

L7N 3V2

Research Site, Burlington

L3M 1P3

Research Site, Grimsby

L8N 3Z5

Research Site, Hamilton

H4J 1C5

Research Site, Montreal

H9R 3J1

Research Site, Pointe-Claire

G1G 3Y8

Research Site, Québec

G1V 4G5

Research Site, Québec

G1V 4W2

Research Site, Québec

J6E 2B4

Research Site, Saint-Charles-Borromée

G8T 7A1

Research Site, Trois-Rivières

S7N 0W8

Research Site, Saskatoon

377 01

Research Site, Jindřichův Hradec

360 17

Research Site, Karlovy Vary

278 01

Research Site, Kralupy nad Vltavou

293 50

Research Site, Mladá Boleslav

775 21

Research Site, Olomouc

182 00

Research Site, Prague

337 22

Research Site, Rokycany

386 01

Research Site, Strakonice

415 01

Research Site, Teplice

04357

Research Site, Leipzig

06682

Research Site, Teuchern

H-6722

Research Site, Szeged

103-0027

Research Site, Chūōku

811-1394

Research Site, Fukuoka

819-8555

Research Site, Fukuoka

720-0001

Research Site, Fukuyama-shi

311-3193

Research Site, Higashiibaraki-gun

670-0849

Research Site, Himeji-shi

672-8064

Research Site, Himeji-shi

036-8545

Research Site, Hirosaki-shi

438-8550

Research Site, Iwata-shi

693-8501

Research Site, Izumo-shi

610-0113

Research Site, Joyo-shi

890-0064

Research Site, Kagoshima

816-0813

Research Site, Kasuga-shi

486-8510

Research Site, Kasugai-shi

333-0833

Research Site, Kawaguchi-shi

211-0041

Research Site, Kawasaki-shi

376-0024

Research Site, Kiryu-shi

596-8501

Research Site, Kishiwada-shi

024-8506

Research Site, Kitakami-shi

650-0047

Research Site, Kobe

780-8077

Research Site, Kochi

187-0024

Research Site, Kodaira-shi

185-0014

Research Site, Kokubunji-shi

861-1196

Research Site, Koshi-shi

349-1105

Research Site, Kuki-shi

862-0921

Research Site, Kumamoto

711-0921

Research Site, Kurashiki-shi

830-0011

Research Site, Kurume-shi

615-8256

Research Site, Kyoto

690-8506

Research Site, Matsue

690-8556

Research Site, Matsue

390-0872

Research Site, Matsumoto-shi

515-8544

Research Site, Matsusaka-shi

153-8515

Research Site, Meguro-ku

509-6134

Research Site, Mizunami-shi

020-0055

Research Site, Morioka

940-8621

Research Site, Nagaoka-shi

454-8509

Research Site, Nagoya

455-8530

Research Site, Nagoya

950-2085

Research Site, Niigata

080-0805

Research Site, Obihiro-shi

145-0063

Research Site, Ohota-ku

373-8585

Research Site, Ota-shi

876-0813

Research Site, Saiki-shi

762-8550

Research Site, Sakaide-shi

591-8555

Research Site, Sakaishi

001-0901

Research Site, Sapporo

060-0033

Research Site, Sapporo

063-0005

Research Site, Sapporo

064-0804

Research Site, Sapporo

984-8560

Research Site, Sendai

489-8642

Research Site, Seto-shi

142-8666

Research Site, Shinagawa-ku

162-8655

Research Site, Shinjuku-ku

761-8073

Research Site, Takamatsu

569-1096

Research Site, Takatsuki-shi

791-0281

Research Site, Toon-shi

171-0014

Research Site, Toshima-ku

755-0241

Research Site, Ube-shi

386-8610

Research Site, Ueda-shi

611-0041

Research Site, Uji-shi

901-2132

Research Site, Urasoe-shi

904-2293

Research Site, Uruma

276-8524

Research Site, Yachiyo-shi

581-0011

Research Site, Yakushi

832-0059

Research Site, Yanagawa-shi

232-0024

Research Site, Yokohama

234-0054

Research Site, Yokohama

236-0004

Research Site, Yokohama

236-0051

Research Site, Yokohama

4818 CK

Research Site, Breda

5623 EJ

Research Site, Eindhoven

6419 PC

Research Site, Heerlen

6085 NM

Research Site, Horn

6525 GA

Research Site, Nijmegen

8025 AB

Research Site, Zwolle

85-681

Research Site, Bydgoszcz

11-040

Research Site, Dobre Miasto

80-405

Research Site, Gdansk

Unknown

Research Site, Gdansk

Research Site, Zakopane

Research Site, LE3 9QP

40-081

Research Site, Katowice

64-000

Research Site, Kościan

31-011

Research Site, Krakow

31-209

Research Site, Krakow

90-153

Research Site, Lodz

20-064

Research Site, Lublin

20-089

Research Site, Lublin

20-468

Research Site, Lublin

11-700

Research Site, Mrągowo

05-320

Research Site, Mrozy

10-357

Research Site, Olsztyn

32-100

Research Site, Proszowice

26-617

Research Site, Radom

41-709

Research Site, Ruda Śląska

35-241

Research Site, Rzeszów

33-100

Research Site, Tarnów

02-507

Research Site, Warsaw

50-220

Research Site, Wroclaw

53-201

Research Site, Wroclaw

077025

Research Site, Bragadiru

030303

Research Site, Bucharest

03312

Research Site, Seoul

04401

Research Site, Seoul

05030

Research Site, Seoul

06591

Research Site, Seoul

03004

Research Site, Alicante

08916

Research Site, Badalona(Barcelona)

08003

Research Site, Barcelona

08025

Research Site, Barcelona

08036

Research Site, Barcelona

07010

Research Site, Palma de Mallorca

08208

Research Site, Sabadell (Barcelona)

CH-9202

Research Site, Gossau

CH-4410

Research Site, Liestal

AB25 2ZG

Research Site, Aberdeen

B9 5SS

Research Site, Birmingham

BD9 6RJ

Research Site, Bradford

CB2 0QQ

Research Site, Cambridge

KT16 0PZ

Research Site, Chertsey

EH16 4TJ

Research Site, Edinburgh

G12 0YN

Research Site, Glasgow

SE5 9PJ

Research Site, London

M23 9QZ

Research Site, Manchester

M6 8HD

Research Site, Manchester

NE7 7DN

Research Site, Newcastle upon Tyne

ST4 6QG

Research Site, Newcastle-under-Lyme

OX3 7LE

Research Site, Oxford

PL6 8DH

Research Site, Plymouth

SO166YD

Research Site, Southampton

ML2 0DP

Research Site, Wishaw

WV10 0QP

Research Site, Wolverhampton

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

MedImmune LLC

INDUSTRY

lead

AstraZeneca

INDUSTRY