685
Participants
Start Date
April 21, 2014
Primary Completion Date
February 28, 2026
Study Completion Date
February 28, 2031
Cisplatin
Given IV
Clinical Observation
Undergo clinical observation
Fluorouracil
Given IV
Gemcitabine Hydrochloride
Given IV
Intensity-Modulated Radiation Therapy
Undergo IMRT
Laboratory Biomarker Analysis
Correlative studies
Paclitaxel
Given IV
Quality-of-Life Assessment
Ancillary studies
National Taiwan University Hospital, Taipei
Peter MacCallum Cancer Centre, Melbourne
Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York
New York Proton Center, New York
Memorial Sloan Kettering Cancer Center, New York
Montefiore Medical Center-Einstein Campus, The Bronx
Montefiore Medical Center - Moses Campus, The Bronx
Memorial Sloan Kettering Sleepy Hollow, Sleepy Hollow
Memorial Sloan Kettering Westchester, Harrison
New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn
Maimonides Medical Center, Brooklyn
Memorial Sloan Kettering Nassau, Uniondale
Memorial Sloan Kettering Commack, Commack
University of Rochester, Rochester
Lewistown Hospital, Lewistown
Geisinger Medical Center, Danville
Geisinger Medical Oncology-Lewisburg, Lewisburg
Geisinger Cancer Services-Pottsville, Pottsville
Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre
Christiana Care Health System-Concord Health Center, Chadds Ford
Reading Hospital, West Reading
Helen F Graham Cancer Center, Newark
Christiana Care Health System-Christiana Hospital, Newark
Greater Baltimore Medical Center, Baltimore
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
Inova Schar Cancer Institute, Fairfax
Inova Fairfax Hospital, Falls Church
Spartanburg Medical Center, Spartanburg
Prisma Health Cancer Institute - Spartanburg, Boiling Springs
Prisma Health Cancer Institute - Faris, Greenville
Saint Francis Cancer Center, Greenville
Prisma Health Cancer Institute - Eastside, Greenville
Prisma Health Cancer Institute - Greer, Greer
Gibbs Cancer Center-Pelham, Greer
Prisma Health Cancer Institute - Seneca, Seneca
Emory Proton Therapy Center, Atlanta
Emory University Hospital Midtown, Atlanta
Emory University Hospital/Winship Cancer Institute, Atlanta
Emory Saint Joseph's Hospital, Atlanta
Baptist MD Anderson Cancer Center, Jacksonville
Chang Gung Hospital-Lin Kou Medical Center, Taoyuan District
Moffitt Cancer Center, Tampa
University of Alabama at Birmingham Cancer Center, Birmingham
The Kirklin Clinic at Acton Road, Birmingham
Ohio State University Comprehensive Cancer Center, Columbus
ProMedica Flower Hospital, Sylvania
Geauga Hospital, Chardon
Mercy Cancer Center-Elyria, Elyria
Case Western Reserve University, Cleveland
Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland
Cleveland Clinic Cancer Center Strongsville, Strongsville
UHHS-Westlake Medical Center, Westlake
Cleveland Clinic Foundation, Cleveland
Cleveland Clinic Akron General, Akron
Cleveland Clinic Wooster Family Health and Surgery Center, Wooster
North Coast Cancer Care, Sandusky
Cleveland Clinic Cancer Center Mansfield, Mansfield
University of Cincinnati Cancer Center-West Chester, West Chester
University of Cincinnati Cancer Center-UC Medical Center, Cincinnati
Memorial Hospital of South Bend, South Bend
Henry Ford Macomb Hospital-Clinton Township, Clinton Township
McLaren Cancer Institute-Macomb, Mount Clemens
McLaren-Port Huron, Port Huron
Saint Joseph Mercy Hospital, Ann Arbor
University of Michigan Comprehensive Cancer Center, Ann Arbor
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia
Henry Ford Cancer Institute-Downriver, Brownstown
Saint Joseph Mercy Canton, Canton
Wayne State University/Karmanos Cancer Institute, Detroit
Henry Ford Hospital, Detroit
Henry Ford West Bloomfield Hospital, West Bloomfield
Weisberg Cancer Treatment Center, Farmington Hills
Saint Joseph Mercy Oakland, Pontiac
McLaren Cancer Institute-Clarkston, Clarkston
McLaren Cancer Institute-Lapeer Region, Lapeer
McLaren Cancer Institute-Flint, Flint
Singh and Arora Hematology Oncology PC, Flint
Ascension Saint Mary's Hospital, Saginaw
McLaren Cancer Institute-Bay City, Bay City
McLaren Cancer Institute-Central Michigan, Mount Pleasant
Karmanos Cancer Institute at McLaren Greater Lansing, Lansing
Mid-Michigan Physicians-Lansing, Lansing
Sparrow Hospital, Lansing
McLaren Cancer Institute-Northern Michigan, Petoskey
Iowa Methodist Medical Center, Des Moines
University of Iowa/Holden Comprehensive Cancer Center, Iowa City
Medical College of Wisconsin, Milwaukee
University of Wisconsin Carbone Cancer Center, Madison
Aspirus Regional Cancer Center, Wausau
Langlade Hospital and Cancer Center, Antigo
Marshfield Medical Center-Marshfield, Marshfield
Marshfield Medical Center, Marshfield
Diagnostic and Treatment Center, Weston
Marshfield Medical Center - Weston, Weston
Ascension Saint Michael's Hospital, Stevens Point
Marshfield Medical Center-River Region at Stevens Point, Stevens Point
Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids
Marshfield Clinic-Minocqua Center, Minocqua
Gundersen Lutheran Medical Center, La Crosse
HSHS Sacred Heart Hospital, Eau Claire
Marshfield Medical Center-EC Cancer Center, Eau Claire
Marshfield Medical Center-Rice Lake, Rice Lake
Regions Hospital, Saint Paul
Minnesota Oncology Hematology PA-Maplewood, Maplewood
Fairview Ridges Hospital, Burnsville
Minnesota Oncology - Burnsville, Burnsville
Abbott-Northwestern Hospital, Minneapolis
Hennepin County Medical Center, Minneapolis
North Memorial Medical Health Center, Robbinsdale
Unity Hospital, Fridley
Mayo Clinic in Rochester, Rochester
Rice Memorial Hospital, Willmar
Saint James Community Hospital and Cancer Treatment Center, Butte
Rush - Copley Medical Center, Aurora
Northwestern University, Chicago
John H Stroger Jr Hospital of Cook County, Chicago
Carle Cancer Center, Urbana
Crossroads Cancer Center, Effingham
Cancer Care Specialists of Illinois - Decatur, Decatur
Decatur Memorial Hospital, Decatur
Memorial Medical Center, Springfield
Washington University School of Medicine, St Louis
Siteman Cancer Center-South County, St Louis
Siteman Cancer Center at West County Hospital, Creve Coeur
Mercy Hospital Saint Louis, St Louis
Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters
Saint Francis Medical Center, Cape Girardeau
Delbert Day Cancer Institute at PCRMC, Rolla
Mercy Hospital Springfield, Springfield
CoxHealth South Hospital, Springfield
Ascension Via Christi Hospitals Wichita, Wichita
Wesley Medical Center, Wichita
Nebraska Methodist Hospital, Omaha
University of Oklahoma Health Sciences Center, Oklahoma City
Mercy Hospital Oklahoma City, Oklahoma City
UT Southwestern/Simmons Cancer Center-Dallas, Dallas
M D Anderson Cancer Center, Houston
SCL Health Lutheran Medical Center, Wheat Ridge
Parker Adventist Hospital, Parker
SCL Health Cancer Centers of Colorado - Lutheran Medical Center, Golden
McKee Medical Center, Loveland
North Colorado Medical Center, Greeley
Saint Alphonsus Cancer Care Center-Boise, Boise
American Fork Hospital / Huntsman Intermountain Cancer Center, American Fork
Riverton Hospital, Riverton
Utah Cancer Specialists-Salt Lake City, Salt Lake City
Intermountain Medical Center, Murray
Logan Regional Hospital, Logan
McKay-Dee Hospital Center, Ogden
Utah Valley Regional Medical Center, Provo
Sandra L Maxwell Cancer Center, Cedar City
Saint George Regional Medical Center, St. George
Banner University Medical Center - Tucson, Tucson
Radiation Oncology Centers of Nevada Central, Las Vegas
Radiation Oncology Centers of Nevada Southeast, Las Vegas
Renown Regional Medical Center, Reno
Saint Mary's Regional Medical Center, Reno
City of Hope Comprehensive Cancer Center, Duarte
City of Hope South Pasadena, South Pasadena
UC San Diego Moores Cancer Center, La Jolla
UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
Fresno Cancer Center, Fresno
Mills-Peninsula Medical Center, Burlingame
Kaiser Permanente Cancer Treatment Center, South San Francisco
Palo Alto Medical Foundation-Sunnyvale, Sunnyvale
California Pacific Medical Center-Pacific Campus, San Francisco
UCSF Medical Center-Mount Zion, San Francisco
UCSF Medical Center-Mission Bay, San Francisco
Palo Alto Medical Foundation Health Care, Palo Alto
Stanford Cancer Institute Palo Alto, Palo Alto
Kaiser Permanente Dublin, Dublin
Kaiser Permanente Oakland-Broadway, Oakland
Alta Bates Summit Medical Center-Herrick Campus, Berkeley
Rohnert Park Cancer Center, Rohnert Park
Kaiser Permanente Medical Center - Santa Clara, Santa Clara
Memorial Medical Center, Modesto
Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn
Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville
Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova
The Permanente Medical Group-Roseville Radiation Oncology, Roseville
Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park
Sutter Cancer Centers Radiation Oncology Services-Vacaville, Vacaville
Sutter Medical Center Sacramento, Sacramento
University of California Davis Comprehensive Cancer Center, Sacramento
South Sacramento Cancer Center, Sacramento
The Cancer Center of Hawaii-Pali Momi, ‘Aiea
Queen's Medical Center, Honolulu
The Cancer Center of Hawaii-Liliha, Honolulu
Legacy Mount Hood Medical Center, Gresham
Legacy Good Samaritan Hospital and Medical Center, Portland
Legacy Salmon Creek Hospital, Vancouver
National Cancer Centre Singapore, Singapore
Zhongshan Hospital Fudan University, Guangdong Province
Sun Yat-sen University Cancer Center, Guangzhou
Yale University, New Haven
Tufts Medical Center, Boston
Massachusetts General Hospital Cancer Center, Boston
Boston Medical Center, Boston
Memorial Sloan Kettering Basking Ridge, Basking Ridge
Memorial Sloan Kettering Monmouth, Middletown
Memorial Sloan Kettering Bergen, Montvale
Rutgers Cancer Institute of New Jersey, New Brunswick
Rutgers New Jersey Medical School, Newark
Naval Medical Center - Portsmouth, Portsmouth
Tom Baker Cancer Centre, Calgary
Cross Cancer Institute, Edmonton
London Regional Cancer Program, London
University Health Network-Princess Margaret Hospital, Toronto
McGill University Department of Oncology, Montreal
The Research Institute of the McGill University Health Centre (MUHC), Montreal
Jewish General Hospital, Montreal
Chinese University of Hong Kong-Prince of Wales Hospital, Shatin
Pamela Youde Nethersole Eastern Hospital, Chai Wan
Centro Comprensivo de Cancer de UPR, San Juan
Lead Sponsor
National Cancer Institute (NCI)
NIH
NRG Oncology
OTHER