Individualized Treatment in Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA

PHASE2/PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

685

Participants

Timeline

Start Date

April 21, 2014

Primary Completion Date

February 28, 2026

Study Completion Date

February 28, 2031

Conditions
Epstein-Barr Virus InfectionStage II Nasopharyngeal CarcinomaStage III Nasopharyngeal CarcinomaStage IVA Nasopharyngeal CarcinomaStage IVB Nasopharyngeal Carcinoma
Interventions
DRUG

Cisplatin

Given IV

OTHER

Clinical Observation

Undergo clinical observation

DRUG

Fluorouracil

Given IV

DRUG

Gemcitabine Hydrochloride

Given IV

RADIATION

Intensity-Modulated Radiation Therapy

Undergo IMRT

OTHER

Laboratory Biomarker Analysis

Correlative studies

DRUG

Paclitaxel

Given IV

OTHER

Quality-of-Life Assessment

Ancillary studies

Trial Locations (215)

100

National Taiwan University Hospital, Taipei

3000

Peter MacCallum Cancer Centre, Melbourne

10016

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

10032

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

10035

New York Proton Center, New York

10065

Memorial Sloan Kettering Cancer Center, New York

10461

Montefiore Medical Center-Einstein Campus, The Bronx

10467

Montefiore Medical Center - Moses Campus, The Bronx

10591

Memorial Sloan Kettering Sleepy Hollow, Sleepy Hollow

10604

Memorial Sloan Kettering Westchester, Harrison

11215

New York-Presbyterian/Brooklyn Methodist Hospital, Brooklyn

11219

Maimonides Medical Center, Brooklyn

11553

Memorial Sloan Kettering Nassau, Uniondale

11725

Memorial Sloan Kettering Commack, Commack

14642

University of Rochester, Rochester

17044

Lewistown Hospital, Lewistown

17822

Geisinger Medical Center, Danville

17837

Geisinger Medical Oncology-Lewisburg, Lewisburg

17901

Geisinger Cancer Services-Pottsville, Pottsville

18711

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

19317

Christiana Care Health System-Concord Health Center, Chadds Ford

19611

Reading Hospital, West Reading

19713

Helen F Graham Cancer Center, Newark

19718

Christiana Care Health System-Christiana Hospital, Newark

21204

Greater Baltimore Medical Center, Baltimore

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

22031

Inova Schar Cancer Institute, Fairfax

22042

Inova Fairfax Hospital, Falls Church

29303

Spartanburg Medical Center, Spartanburg

29316

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29605

Prisma Health Cancer Institute - Faris, Greenville

29607

Saint Francis Cancer Center, Greenville

29615

Prisma Health Cancer Institute - Eastside, Greenville

29650

Prisma Health Cancer Institute - Greer, Greer

29651

Gibbs Cancer Center-Pelham, Greer

29672

Prisma Health Cancer Institute - Seneca, Seneca

30308

Emory Proton Therapy Center, Atlanta

Emory University Hospital Midtown, Atlanta

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

30342

Emory Saint Joseph's Hospital, Atlanta

32207

Baptist MD Anderson Cancer Center, Jacksonville

33333

Chang Gung Hospital-Lin Kou Medical Center, Taoyuan District

33612

Moffitt Cancer Center, Tampa

35233

University of Alabama at Birmingham Cancer Center, Birmingham

35243

The Kirklin Clinic at Acton Road, Birmingham

43210

Ohio State University Comprehensive Cancer Center, Columbus

43560

ProMedica Flower Hospital, Sylvania

44024

Geauga Hospital, Chardon

44035

Mercy Cancer Center-Elyria, Elyria

44106

Case Western Reserve University, Cleveland

44111

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland

44136

Cleveland Clinic Cancer Center Strongsville, Strongsville

44145

UHHS-Westlake Medical Center, Westlake

44195

Cleveland Clinic Foundation, Cleveland

44307

Cleveland Clinic Akron General, Akron

44691

Cleveland Clinic Wooster Family Health and Surgery Center, Wooster

44870

North Coast Cancer Care, Sandusky

44906

Cleveland Clinic Cancer Center Mansfield, Mansfield

45069

University of Cincinnati Cancer Center-West Chester, West Chester

45219

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati

46601

Memorial Hospital of South Bend, South Bend

48038

Henry Ford Macomb Hospital-Clinton Township, Clinton Township

48043

McLaren Cancer Institute-Macomb, Mount Clemens

48060

McLaren-Port Huron, Port Huron

48106

Saint Joseph Mercy Hospital, Ann Arbor

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

48154

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48183

Henry Ford Cancer Institute-Downriver, Brownstown

48188

Saint Joseph Mercy Canton, Canton

48201

Wayne State University/Karmanos Cancer Institute, Detroit

48202

Henry Ford Hospital, Detroit

48322

Henry Ford West Bloomfield Hospital, West Bloomfield

48334

Weisberg Cancer Treatment Center, Farmington Hills

48341

Saint Joseph Mercy Oakland, Pontiac

48346

McLaren Cancer Institute-Clarkston, Clarkston

48446

McLaren Cancer Institute-Lapeer Region, Lapeer

48532

McLaren Cancer Institute-Flint, Flint

Singh and Arora Hematology Oncology PC, Flint

48601

Ascension Saint Mary's Hospital, Saginaw

48706

McLaren Cancer Institute-Bay City, Bay City

48858

McLaren Cancer Institute-Central Michigan, Mount Pleasant

48910

Karmanos Cancer Institute at McLaren Greater Lansing, Lansing

48912

Mid-Michigan Physicians-Lansing, Lansing

Sparrow Hospital, Lansing

49770

McLaren Cancer Institute-Northern Michigan, Petoskey

50309

Iowa Methodist Medical Center, Des Moines

52242

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53226

Medical College of Wisconsin, Milwaukee

53792

University of Wisconsin Carbone Cancer Center, Madison

54401

Aspirus Regional Cancer Center, Wausau

54409

Langlade Hospital and Cancer Center, Antigo

54449

Marshfield Medical Center-Marshfield, Marshfield

Marshfield Medical Center, Marshfield

54476

Diagnostic and Treatment Center, Weston

Marshfield Medical Center - Weston, Weston

54481

Ascension Saint Michael's Hospital, Stevens Point

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54494

Aspirus Cancer Care - Wisconsin Rapids, Wisconsin Rapids

54548

Marshfield Clinic-Minocqua Center, Minocqua

54601

Gundersen Lutheran Medical Center, La Crosse

54701

HSHS Sacred Heart Hospital, Eau Claire

Marshfield Medical Center-EC Cancer Center, Eau Claire

54868

Marshfield Medical Center-Rice Lake, Rice Lake

55101

Regions Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

55337

Fairview Ridges Hospital, Burnsville

Minnesota Oncology - Burnsville, Burnsville

55407

Abbott-Northwestern Hospital, Minneapolis

55415

Hennepin County Medical Center, Minneapolis

55422

North Memorial Medical Health Center, Robbinsdale

55432

Unity Hospital, Fridley

55905

Mayo Clinic in Rochester, Rochester

56201

Rice Memorial Hospital, Willmar

59701

Saint James Community Hospital and Cancer Treatment Center, Butte

60504

Rush - Copley Medical Center, Aurora

60611

Northwestern University, Chicago

60612

John H Stroger Jr Hospital of Cook County, Chicago

61801

Carle Cancer Center, Urbana

62401

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62781

Memorial Medical Center, Springfield

63110

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center-South County, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

Mercy Hospital Saint Louis, St Louis

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

63703

Saint Francis Medical Center, Cape Girardeau

65401

Delbert Day Cancer Institute at PCRMC, Rolla

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

67214

Ascension Via Christi Hospitals Wichita, Wichita

Wesley Medical Center, Wichita

68114

Nebraska Methodist Hospital, Omaha

73104

University of Oklahoma Health Sciences Center, Oklahoma City

73120

Mercy Hospital Oklahoma City, Oklahoma City

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

77030

M D Anderson Cancer Center, Houston

80033

SCL Health Lutheran Medical Center, Wheat Ridge

80138

Parker Adventist Hospital, Parker

80401

SCL Health Cancer Centers of Colorado - Lutheran Medical Center, Golden

80539

McKee Medical Center, Loveland

80631

North Colorado Medical Center, Greeley

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

84003

American Fork Hospital / Huntsman Intermountain Cancer Center, American Fork

84065

Riverton Hospital, Riverton

84106

Utah Cancer Specialists-Salt Lake City, Salt Lake City

84107

Intermountain Medical Center, Murray

84321

Logan Regional Hospital, Logan

84403

McKay-Dee Hospital Center, Ogden

84604

Utah Valley Regional Medical Center, Provo

84720

Sandra L Maxwell Cancer Center, Cedar City

84770

Saint George Regional Medical Center, St. George

85719

Banner University Medical Center - Tucson, Tucson

89106

Radiation Oncology Centers of Nevada Central, Las Vegas

89119

Radiation Oncology Centers of Nevada Southeast, Las Vegas

89502

Renown Regional Medical Center, Reno

89503

Saint Mary's Regional Medical Center, Reno

91010

City of Hope Comprehensive Cancer Center, Duarte

91030

City of Hope South Pasadena, South Pasadena

92093

UC San Diego Moores Cancer Center, La Jolla

92868

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

93720

Fresno Cancer Center, Fresno

94010

Mills-Peninsula Medical Center, Burlingame

94080

Kaiser Permanente Cancer Treatment Center, South San Francisco

94086

Palo Alto Medical Foundation-Sunnyvale, Sunnyvale

94115

California Pacific Medical Center-Pacific Campus, San Francisco

UCSF Medical Center-Mount Zion, San Francisco

94158

UCSF Medical Center-Mission Bay, San Francisco

94301

Palo Alto Medical Foundation Health Care, Palo Alto

94304

Stanford Cancer Institute Palo Alto, Palo Alto

94568

Kaiser Permanente Dublin, Dublin

94611

Kaiser Permanente Oakland-Broadway, Oakland

94704

Alta Bates Summit Medical Center-Herrick Campus, Berkeley

94928

Rohnert Park Cancer Center, Rohnert Park

95051

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95355

Memorial Medical Center, Modesto

95603

Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn

95661

Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville

95670

Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova

95678

The Permanente Medical Group-Roseville Radiation Oncology, Roseville

95682

Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park

95687

Sutter Cancer Centers Radiation Oncology Services-Vacaville, Vacaville

95816

Sutter Medical Center Sacramento, Sacramento

95817

University of California Davis Comprehensive Cancer Center, Sacramento

95823

South Sacramento Cancer Center, Sacramento

96701

The Cancer Center of Hawaii-Pali Momi, ‘Aiea

96813

Queen's Medical Center, Honolulu

96817

The Cancer Center of Hawaii-Liliha, Honolulu

97030

Legacy Mount Hood Medical Center, Gresham

97210

Legacy Good Samaritan Hospital and Medical Center, Portland

98686

Legacy Salmon Creek Hospital, Vancouver

169610

National Cancer Centre Singapore, Singapore

200032

Zhongshan Hospital Fudan University, Guangdong Province

510060

Sun Yat-sen University Cancer Center, Guangzhou

06520

Yale University, New Haven

02111

Tufts Medical Center, Boston

02114

Massachusetts General Hospital Cancer Center, Boston

02118

Boston Medical Center, Boston

07920

Memorial Sloan Kettering Basking Ridge, Basking Ridge

07748

Memorial Sloan Kettering Monmouth, Middletown

07645

Memorial Sloan Kettering Bergen, Montvale

08903

Rutgers Cancer Institute of New Jersey, New Brunswick

07101

Rutgers New Jersey Medical School, Newark

23708-2197

Naval Medical Center - Portsmouth, Portsmouth

T2N 4N2

Tom Baker Cancer Centre, Calgary

T6G 1Z2

Cross Cancer Institute, Edmonton

N6A 4L6

London Regional Cancer Program, London

M5G 2M9

University Health Network-Princess Margaret Hospital, Toronto

H2W 1S6

McGill University Department of Oncology, Montreal

H3H 2R9

The Research Institute of the McGill University Health Centre (MUHC), Montreal

H3T 1E2

Jewish General Hospital, Montreal

Unknown

Chinese University of Hong Kong-Prince of Wales Hospital, Shatin

Pamela Youde Nethersole Eastern Hospital, Chai Wan

00927

Centro Comprensivo de Cancer de UPR, San Juan

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

NRG Oncology

OTHER