Efficacy and Safety of Semaglutide Once Weekly Versus Insulin Glargine Once Daily as add-on to Metformin With or Without Sulphonylurea in Insulin-naïve Subjects With Type 2 Diabetes

PHASE3CompletedINTERVENTIONAL
Enrollment

1,089

Participants

Timeline

Start Date

August 4, 2014

Primary Completion Date

September 3, 2015

Study Completion Date

September 3, 2015

Conditions
DiabetesDiabetes Mellitus, Type 2
Interventions
DRUG

semaglutide

Injected subcutaneously (under the skin) once weekly. Following 4 doses (4 weeks) of 0.25 mg semaglutide weekly subjects will receive 0.5 mg semaglutide weekly for 26 weeks.

DRUG

insulin glargine

Injected subcutaneously (under the skin) once daily. Subjects will start on 10 IU once daily and the dose will be adjusted according to fasting plasma glucose.

Trial Locations (231)

1000

Novo Nordisk Investigational Site, Skopje

1220

Novo Nordisk Investigational Site, Tetovo

1525

Novo Nordisk Investigational Site, Ljubljana

1829

Novo Nordisk Investigational Site, Johannesburg

2001

Novo Nordisk Investigational Site, Johannesburg

4001

Novo Nordisk Investigational Site, Durban

7450

Novo Nordisk Investigational Site, Cape Town

8000

Novo Nordisk Investigational Site, Novo Mesto

10409

Novo Nordisk Investigational Site, Berlin

11108

Novo Nordisk Investigational Site, Narbonne

11229

Novo Nordisk Investigational Site, Brooklyn

11550

Novo Nordisk Investigational Site, México D.F.

12553

Novo Nordisk Investigational Site, New Windsor

13285

Novo Nordisk Investigational Site, Marseille

13385

Novo Nordisk Investigational Site, Marseille Cédex 05

14080

Novo Nordisk Investigational Site, Distrito Federal

14224

Novo Nordisk Investigational Site, West Seneca

15009

Novo Nordisk Investigational Site, Beaver

16602

Novo Nordisk Investigational Site, Altoona

17740

Novo Nordisk Investigational Site, Jersey Shore

18057

Novo Nordisk Investigational Site, Rostock

19114

Novo Nordisk Investigational Site, Philadelphia

20230

Novo Nordisk Investigational Site, Aguascalientes

20782

Novo Nordisk Investigational Site, Hyattsville

22206

Novo Nordisk Investigational Site, Arlington

22601

Novo Nordisk Investigational Site, Winchester

27408

Novo Nordisk Investigational Site, Greensboro

28150

Novo Nordisk Investigational Site, Shelby

28401

Novo Nordisk Investigational Site, Wilmington

28557

Novo Nordisk Investigational Site, Morehead City

28625

Novo Nordisk Investigational Site, Statesville

28655

Novo Nordisk Investigational Site, Morganton

29341

Novo Nordisk Investigational Site, Gaffney

29576

Novo Nordisk Investigational Site, Murrells Inlet

30013

Novo Nordisk Investigational Site, Conyers

30060

Novo Nordisk Investigational Site, Marietta

30076

Novo Nordisk Investigational Site, Roswell

30092

Novo Nordisk Investigational Site, Norcross

30097

Novo Nordisk Investigational Site, Johns Creek

32205

Novo Nordisk Investigational Site, Jacksonville

32216

Novo Nordisk Investigational Site, Jacksonville

32256

Novo Nordisk Investigational Site, Jacksonville

32789

Novo Nordisk Investigational Site, Winter Park

33012

Novo Nordisk Investigational Site, Hialeah

33016

Novo Nordisk Investigational Site, Miami Lakes

33024

Novo Nordisk Investigational Site, Cooper City

33135

Novo Nordisk Investigational Site, Miami

33156

Novo Nordisk Investigational Site, Miami

33761

Novo Nordisk Investigational Site, Clearwater

33805

Novo Nordisk Investigational Site, Lakeland

33880

Novo Nordisk Investigational Site, Winter Haven

34609

Novo Nordisk Investigational Site, Spring Hill

34741

Novo Nordisk Investigational Site, Kissimmee

35216

Novo Nordisk Investigational Site, Birmingham

35674

Novo Nordisk Investigational Site, Tuscumbia

36360

Novo Nordisk Investigational Site, Ozark

37404

Novo Nordisk Investigational Site, Chattanooga

37912

Novo Nordisk Investigational Site, Knoxville

38302

Novo Nordisk Investigational Site, Bourgoin

39319

Novo Nordisk Investigational Site, Jerichow

40000

Novo Nordisk Investigational Site, Čakovec

40503

Novo Nordisk Investigational Site, Lexington

42003

Novo Nordisk Investigational Site, Paducah

42431

Novo Nordisk Investigational Site, Madisonville

43537

Novo Nordisk Investigational Site, Maumee

43623

Novo Nordisk Investigational Site, Toledo

44122

Novo Nordisk Investigational Site, Cleveland

44150

Novo Nordisk Investigational Site, Guadalajara

44600

Novo Nordisk Investigational Site, Saint-Nazaire

44614

Novo Nordisk Investigational Site, Canal Fulton

44800

Novo Nordisk Investigational Site, Saint-Herblain

45005

Novo Nordisk Investigational Site, Carlisle

45219

Novo Nordisk Investigational Site, Cincinnati

45227

Novo Nordisk Investigational Site, Cincinnati

45242

Novo Nordisk Investigational Site, Cincinnati

45255

Novo Nordisk Investigational Site, Cincinnati

45276

Novo Nordisk Investigational Site, Essen

45429

Novo Nordisk Investigational Site, Kettering

46123

Novo Nordisk Investigational Site, Avon

46254

Novo Nordisk Investigational Site, Indianapolis

47000

Novo Nordisk Investigational Site, Karlovac

48098

Novo Nordisk Investigational Site, Troy

48145

Novo Nordisk Investigational Site, Münster

48504

Novo Nordisk Investigational Site, Flint

49217

Novo Nordisk Investigational Site, Krapinske Toplice

49620

Novo Nordisk Investigational Site, Buckley

51501

Novo Nordisk Investigational Site, Council Bluffs

53144

Novo Nordisk Investigational Site, Kenosha

56564

Novo Nordisk Investigational Site, Neuwied

57701

Novo Nordisk Investigational Site, Rapid City

58104

Novo Nordisk Investigational Site, Fargo

59701

Novo Nordisk Investigational Site, Butte

60031

Novo Nordisk Investigational Site, Gurnee

60611

Novo Nordisk Investigational Site, Chicago

61602

Novo Nordisk Investigational Site, Peoria

62180

Novo Nordisk Investigational Site, Rang-du-Fliers

63128

Novo Nordisk Investigational Site, St Louis

63141

Novo Nordisk Investigational Site, St Louis

66386

Novo Nordisk Investigational Site, Saint Ingbert-Oberwürzbach

66780

Novo Nordisk Investigational Site, Rehlingen-Siersburg

67059

Novo Nordisk Investigational Site, Ludwigshafen

67098

Novo Nordisk Investigational Site, Strasbourg

67219

Novo Nordisk Investigational Site, Park City

68623

Novo Nordisk Investigational Site, Lampertheim

69200

Novo Nordisk Investigational Site, Vénissieux

69495

Novo Nordisk Investigational Site, Pierre-Bénite

70002

Novo Nordisk Investigational Site, Metairie

70378

Novo Nordisk Investigational Site, Stuttgart

70601

Novo Nordisk Investigational Site, Lake Charles

71107

Novo Nordisk Investigational Site, Shreveport

71200

Novo Nordisk Investigational Site, Le Creusot

75014

Novo Nordisk Investigational Site, Paris

75075

Novo Nordisk Investigational Site, Plano

75251

Novo Nordisk Investigational Site, Dallas

75605

Novo Nordisk Investigational Site, Longview

75670

Novo Nordisk Investigational Site, Marshall

76054

Novo Nordisk Investigational Site, Hurst

76117

Novo Nordisk Investigational Site, Fort Worth

76320

Novo Nordisk Investigational Site, Bois-Guillaume

77040

Novo Nordisk Investigational Site, Houston

77055

Novo Nordisk Investigational Site, Houston

77058

Novo Nordisk Investigational Site, Houston

77070

Novo Nordisk Investigational Site, Houston

77074

Novo Nordisk Investigational Site, Houston

77338

Novo Nordisk Investigational Site, Humble

78209

Novo Nordisk Investigational Site, San Antonio

78229

Novo Nordisk Investigational Site, San Antonio

78756

Novo Nordisk Investigational Site, Austin

79106

Novo Nordisk Investigational Site, Amarillo

80220

Novo Nordisk Investigational Site, Denver

80909

Novo Nordisk Investigational Site, Colorado Springs

83646

Novo Nordisk Investigational Site, Meridian

84107

Novo Nordisk Investigational Site, Salt Lake City

84790

Novo Nordisk Investigational Site, St. George

85018

Novo Nordisk Investigational Site, Phoenix

85032

Novo Nordisk Investigational Site, Phoenix

85295

Novo Nordisk Investigational Site, Gilbert

Novo Nordisk Investigational Site, La Roche-sur-Yon

87108

Novo Nordisk Investigational Site, Albuquerque

88239

Novo Nordisk Investigational Site, Wangen

89109

Novo Nordisk Investigational Site, Las Vegas

89119

Novo Nordisk Investigational Site, Las Vegas

89120

Novo Nordisk Investigational Site, Las Vegas

90057

Novo Nordisk Investigational Site, Los Angeles

90274

Novo Nordisk Investigational Site, Rolling Hills Estates

90301

Novo Nordisk Investigational Site, Inglewood

90807

Novo Nordisk Investigational Site, Long Beach

91101

Novo Nordisk Investigational Site, Trenčín

91403

Novo Nordisk Investigational Site, Sherman Oaks

91911

Novo Nordisk Investigational Site, Chula Vista

91942

Novo Nordisk Investigational Site, La Mesa

91978

Novo Nordisk Investigational Site, Spring Valley

92014

Novo Nordisk Investigational Site, Nanterre

92056

Novo Nordisk Investigational Site, Oceanside

92101

Novo Nordisk Investigational Site, Piešťany

92111

Novo Nordisk Investigational Site, San Diego

92376

Novo Nordisk Investigational Site, Rialto

92780

Novo Nordisk Investigational Site, Tustin

92801

Novo Nordisk Investigational Site, Anaheim

93009

Novo Nordisk Investigational Site, Bobigny

94401

Novo Nordisk Investigational Site, San Mateo

94598

Novo Nordisk Investigational Site, Walnut Creek

95608

Novo Nordisk Investigational Site, Carmichael

95661

Novo Nordisk Investigational Site, Roseville

95758

Novo Nordisk Investigational Site, Elk Grove

97159

Novo Nordisk Investigational Site, Pointe à Pitre

97235

Novo Nordisk Investigational Site, Trinité - La Martinique

98057

Novo Nordisk Investigational Site, Renton

98502

Novo Nordisk Investigational Site, Olympia

110001

Novo Nordisk Investigational Site, New Delhi

110029

Novo Nordisk Investigational Site, New Dehli

110084

Novo Nordisk Investigational Site, Piteşti

380006

Novo Nordisk Investigational Site, Ahmedabad

380007

Novo Nordisk Investigational Site, Ahmedabad

400006

Novo Nordisk Investigational Site, Cluj-Napoca

400008

Novo Nordisk Investigational Site, Mumbai

400010

Novo Nordisk Investigational Site, Mumbai

400012

Novo Nordisk Investigational Site, Mumbai

400022

Novo Nordisk Investigational Site, Mumbai

410469

Novo Nordisk Investigational Site, Oradea

452010

Novo Nordisk Investigational Site, Indore

560092

Novo Nordisk Investigational Site, Bangalore

570001

Novo Nordisk Investigational Site, Mysore

570004

Novo Nordisk Investigational Site, Mysore

600031

Novo Nordisk Investigational Site, Chennai

700026

Novo Nordisk Investigational Site, Kolkata

700107

Novo Nordisk Investigational Site, Kolkata

700469

Novo Nordisk Investigational Site, Iași

92868-2863

Novo Nordisk Investigational Site, Orange

91767-3008

Novo Nordisk Investigational Site, Pomona

80239-3133

Novo Nordisk Investigational Site, Denver

71457-5881

Novo Nordisk Investigational Site, Natchitoches

48310-3503

Novo Nordisk Investigational Site, Sterling Heights

08009

Novo Nordisk Investigational Site, Berlin

08755-8050

Novo Nordisk Investigational Site, Toms River

08611

Novo Nordisk Investigational Site, Trenton

45040-6815

Novo Nordisk Investigational Site, Mason

97330-3737

Novo Nordisk Investigational Site, Corvallis

15025-3730

Novo Nordisk Investigational Site, Clairton

19446-1002

Novo Nordisk Investigational Site, Lansdale

75061-2210

Novo Nordisk Investigational Site, Irving

98801-2028

Novo Nordisk Investigational Site, Wenatchee

C1425AGC

Novo Nordisk Investigational Site, Buenos Aires

C1119ACN

Novo Nordisk Investigational Site, CABA

C1056ABJ

Novo Nordisk Investigational Site, Capital Federal

M5501ARP

Novo Nordisk Investigational Site, Godoy Cruz

10 000

Novo Nordisk Investigational Site, Zagreb

06202

Novo Nordisk Investigational Site, Nice

1105 AZ

Novo Nordisk Investigational Site, Amsterdam

2134 TM

Novo Nordisk Investigational Site, Hoofddorp

3039 BD

Novo Nordisk Investigational Site, Rotterdam

00717

Novo Nordisk Investigational Site, Ponce

011234

Novo Nordisk Investigational Site, Bucharest

04011

Novo Nordisk Investigational Site, Košice

045 01

Novo Nordisk Investigational Site, Moldava nad Bodvou

02001

Novo Nordisk Investigational Site, Púchov

SI-6000

Novo Nordisk Investigational Site, Koper

0183

Novo Nordisk Investigational Site, Pretoria

RG24 9GT

Novo Nordisk Investigational Site, Basingstoke

BS10 5NB

Novo Nordisk Investigational Site, Bristol

HG2 7SX

Novo Nordisk Investigational Site, Harrogate, North Yorkshire

DN9 2HY

Novo Nordisk Investigational Site, Haxey

HU3 2RW

Novo Nordisk Investigational Site, Hull

IP4 5PD

Novo Nordisk Investigational Site, Ipswich

HA6 2RN

Novo Nordisk Investigational Site, Northwood

PL6 8BQ

Novo Nordisk Investigational Site, Plymouth

M6 8HD

Novo Nordisk Investigational Site, Salford

DA14 6LT

Novo Nordisk Investigational Site, Sidcup

CB7 5JD

Novo Nordisk Investigational Site, Soham

SA2 8PP

Novo Nordisk Investigational Site, Swansea

TA1 5DA

Novo Nordisk Investigational Site, Taunton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Novo Nordisk A/S

INDUSTRY

NCT02128932 - Efficacy and Safety of Semaglutide Once Weekly Versus Insulin Glargine Once Daily as add-on to Metformin With or Without Sulphonylurea in Insulin-naïve Subjects With Type 2 Diabetes | Biotech Hunter | Biotech Hunter