NCT02122185View on ClinicalTrials.gov

Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

110

Participants

Timeline

Start Date

February 25, 2015

Primary Completion Date

February 25, 2027

Study Completion Date

February 25, 2027

Conditions
Brenner TumorMalignant AscitesMalignant Pleural EffusionOvarian Clear Cell CystadenocarcinomaOvarian Endometrioid AdenocarcinomaOvarian Mixed Epithelial CarcinomaOvarian Serous CystadenocarcinomaOvarian Undifferentiated AdenocarcinomaRecurrent Fallopian Tube CancerRecurrent Ovarian Epithelial CancerRecurrent Ovarian Germ Cell TumorRecurrent Primary Peritoneal Cavity CancerStage IIIA Fallopian Tube CancerStage IIIA Ovarian Epithelial CancerStage IIIA Ovarian Germ Cell TumorStage IIIA Primary Peritoneal Cavity CancerStage IIIB Fallopian Tube CancerStage IIIB Ovarian Epithelial CancerStage IIIB Ovarian Germ Cell TumorStage IIIB Primary Peritoneal Cavity CancerStage IIIC Fallopian Tube CancerStage IIIC Ovarian Epithelial CancerStage IIIC Ovarian Germ Cell TumorStage IIIC Primary Peritoneal Cavity CancerStage IV Fallopian Tube CancerStage IV Ovarian Epithelial CancerStage IV Ovarian Germ Cell TumorStage IV Primary Peritoneal Cavity Cancer
Interventions
DRUG

metformin hydrochloride

Given PO

DRUG

placebo

Given PO

DRUG

Chemotherapy

Participants will received standard chemotherapy (6-8 cycles). Specific regimen to be given is at the discretion of their treating physician.

Trial Locations (10)

35233

University of Alabama, Birmingham

36604

Mitchell Cancer Institute - University of South Alabama, Mobile

55905

Mayo Clinic, Rochester

60005

NCH Medical Group- Northwest Community Hospital, Arlington Heights

60201

NorthShore University HealthSystem, Evanston

60426

Ingalls Memorial Hospital, Harvey

60612

Rush University Medical Center, Chicago

60637

University of Chicago, Chicago

62526

Decatur Memorial Hospital, Decatur

91010

City of Hope, Duarte

All Listed Sponsors
lead

University of Chicago

OTHER