SAFIR02_Lung - Efficacy of Targeted Drugs Guided by Genomic Profiles in Metastatic NSCLC Patients

PHASE2CompletedINTERVENTIONAL
Enrollment

999

Participants

Timeline

Start Date

April 23, 2014

Primary Completion Date

December 22, 2018

Study Completion Date

December 31, 2023

Conditions
Non-small Cell Lung Cancer Metastatic
Interventions
DRUG

AZD2014

Target: m-TOR

DRUG

AZD4547

Target: FGFR

DRUG

AZD5363

Target: AKT

DRUG

AZD8931

Target: HER2, EGFR

DRUG

Selumetinib

Target: MEK

DRUG

Vandetanib

Target : VEGF, EGFR

DRUG

Standard maintenance for squamous NSCLC

DRUG

Pemetrexed

Standard maintenance for non squamous NSCLC

DRUG

Durvalumab

Target: PD-L1

DRUG

savolitinib

target : MET

DRUG

Olaparib

target : PARP

Trial Locations (37)

Unknown

Centre Hospitalier Henri Duffau, Avignon

Centre Hospitalier Universitaire de Besancon - Hopital Jean Minjoz, Besançon

Hôpital Avicenne, Bobigny

Institut Bergonié, Bordeaux

Hôpital Ambroise Paré, Boulogne-Billancourt

Hospices Civils de Lyon- Hôpital Louis Pradel, Bron

Centre François Baclesse, Caen

CHU Caen, Caen

Chu de Caen - Hopital Cote de Nacre, Caen

Hôpital Louis Pasteur, Chartres

centre Jean Perrin, Clermont-Ferrand

CHU Clermont Ferrand - Hôpital Gabriel Montpied, Clermont-Ferrand

Hopitaux Civils de Colmar, Colmar

Centre Hopsitalier Intercommunal de Créteil, Créteil

Centre Georges François Leclerc, Dijon

CHU Grenoble, Grenoble

Chd Vendee, La Roche-sur-Yon

CH du Mans, Le Mans

Centre Oscar Lambret, Lille

CHRU de Lille, Lille

Centre Léon Bérard, Lyon

Hôpital Nord, Marseille

Institut Paoli Calmettes, Marseille

Institut de cancérologie de l'Ouest, Nantes

Centre Antoine Lacassagne, Nice

Chr Orleans, Orléans

AH-HP Hôpital Saint Louis, Paris

AP-HP Hôpital Cochin, Paris

AP-HP Hôpital Tenon, Paris

Institut Curie, Paris

Centre Hospitalier de Pau, Pau

Centre Hospitalier Lyon Sud, Pierre-Bénite

Chru Strasbourg - Nouvel Hopital Civil, Strasbourg

CHI de Toulon - Hôpital Sainte-Musse, Toulon

CHU Toulouse -Hôpital Larrey, Toulouse

Hôpital Bretonneau, Tours

Gustave Roussy, Villejuif

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Intergroupe Francophone de Cancerologie Thoracique

OTHER

collaborator

Fondation ARC

OTHER

collaborator

AstraZeneca

INDUSTRY

lead

UNICANCER

OTHER