The Tolerability of Saracatinib in Subjects With Lymphangioleiomyomatosis (LAM) (SLAM-1)

PHASE1CompletedINTERVENTIONAL
Enrollment

9

Participants

Timeline

Start Date

August 31, 2014

Primary Completion Date

June 30, 2015

Study Completion Date

July 31, 2015

Conditions
Pulmonary Lymphangioleiomyomatosis
Interventions
DRUG

Saracatinib

Saracatinib is escalated as follows: Three dose levels will be administered for 1 month each: 50 mg, 125 mg and 175 mg. Three subjects will be treated at the lowest daily dose of 50 mg. If no subject experiences DLT (dose limiting toxicity), the dose level is escalated to 125 mg/day for the next cohort of 3 different subjects and so on to next dose.

Trial Locations (3)

45267

University of Cincinnati, Cincinnati

77030

Baylor College of Medicine, Houston

University of Texas Health Science Center-Houston, Houston

All Listed Sponsors
collaborator

University of Texas

OTHER

collaborator

University of Cincinnati

OTHER

lead

Tony Eissa

OTHER

NCT02116712 - The Tolerability of Saracatinib in Subjects With Lymphangioleiomyomatosis (LAM) (SLAM-1) | Biotech Hunter | Biotech Hunter