Study Comparing Veliparib Plus Carboplatin and Paclitaxel Versus Placebo Plus Carboplatin and Paclitaxel in Previously Untreated Advanced or Metastatic Squamous Non-Small Cell Lung Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

970

Participants

Timeline

Start Date

April 10, 2014

Primary Completion Date

January 3, 2017

Study Completion Date

November 20, 2019

Conditions
Squamous Non-Small Cell Lung Cancer
Interventions
DRUG

Carboplatin

Carboplatin administered intravenously over approximately 15 to 30 minutes at (AUC 6 mg/mL/min) immediately following paclitaxel infusion.

DRUG

Veliparib

Capsules taken orally twice a day, 12 hours apart.

DRUG

Paclitaxel

Paclitaxel administered intravenously over 3 hours at a dose of 200 mg/m².

DRUG

Placebo to veliparib

Capsules taken orally twice a day, 12 hours apart.

Trial Locations (225)

1038

Riga East Clinical Univ Hosp /ID# 125597, Riga

1122

Orszagos Koranyi Pulmonologiai Intezet /ID# 126112, Budapest XII

2045

Tudogyogyintezet Toeroekbalint /ID# 126111, Törökbálint

2193

Wits Clinical Research Site /ID# 126101, Johannesburg

2199

Sandton Oncology Centre /ID# 126097, Johannesburg

2500

Southern Medical Day Care Ctr /ID# 125604, Wollongong

2730

Herlev Hospital /ID# 125995, Herlev

3010

Inselspital, Universitaetsklinik /ID# 126347, Bern

3116

Sykehuset i Vestfold HF /ID# 126340, Tønsberg

3220

Barwon Health University Hospital Geelong /ID# 125606, Geelong

3233

Matrahaza Gyogyintezet /ID# 126109, Kékesteto

3529

CRU Hungary Egeszsegugyi és Szolgaltato Kft. /ID# 135234, Miskolc

3600

Spital STS AG /ID# 126348, Thun

4020

Ordensklinikum Linz GmbH, Elisabethinen /ID# 126183, Linz

4032

Debreceni Egyetem Klinikai Központ /ID# 126119, Debrecen

4068

Stavanger University Hospital /ID# 126336, Stavanger

4091

The Oncology Centre /ID# 126096, Durban

4575

Sunshine Coast University Hosp /ID# 125608, Birtinya

4615

Sorlandet Sykehus HF /ID# 126341, Kristiansand

4814

The Townsville Hospital /ID# 125609, Douglas

5000

Odense Universitets Hospital /ID# 125996, Odense C

Hirslanden Medical Center /ID# 128216, Aarau

5004

Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz /ID# 126120, Szolnok

5011

The Queen Elizabeth Hospital /ID# 125607, Woodville

5021

Haukeland University Hospital /ID# 126338, Bergen

5042

Flinders Centre for Innovation /ID# 125605, Bedford Park

5700

Bekes Megyei Pandy Kalman Korhaz /ID# 126117, Gyula

6006

GVI Oncology /ID# 126102, Port Elizabeth

6021

Wellington Hospital (Capital and Coast District Health Board) /ID# 125755, Wellington

6530

Cancercare Outeniqua Oncology Unit /ID# 126103, George

7460

Netcare Oncology Intervent Ctr /ID# 126100, Cape Town

8000

Fejer Megyei Szent Gyorgy Korh /ID# 126118, Székesfehérvár

8005

Nordland Hospital /ID# 126337, Bodø

8582

Veszprem Megyei Tudogyogyintez /ID# 126121, Farkasgyepű

9007

Kantonsspital St. Gallen /ID# 126349, Sankt Gallen

9023

Petz Aladar Megyei Oktato Korh /ID# 126110, Győr

10000

Klinika za plucne bolesti Jordanovac /ID# 126537, Zagreb

10043

A.O.U. San Luigi Gonzaga /ID# 125700, Orbassano

11000

Clinical Center Serbia /ID# 128738, Belgrade

Institute for Oncology and Rad /ID# 128721, Belgrade

11080

University Hospital Bezanijska /ID# 128761, Belgrade

11511

Naser Institute for Res & Dev /ID# 129263, Cairo

11527

General Hospital of Chest Diseases of Athens SOTIRIA /ID# 125879, Athens

11956

Cairo Uni Hosp Al Kasr El Ainy /ID# 128338, Cairo

Cairo Uni Hosp Al Kasr El Ainy /ID# 128340, Cairo

12203

Charite-Univ. Berlin, Benjamin-Franklin /ID# 125708, Berlin

13419

North Estonian Medical Centre /ID# 128215, Tallinn

13915

CHU Hopital Nord /ID# 128388, Marseille

17033

Penn State University and Milton S. Hershey Medical Center /ID# 126676, Hershey

17176

Karolinska Univ Sjukhuset /ID# 126445, Solna

18000

Clinical Center of Nis /ID# 128735, Niš

Cherkassy Regional Onc Ctr /ID# 128222, Cherkasy

18547

Metropolitan Hospital /ID# 125878, Athens

20052

Azienda Ospedaliera San Gerardo di Monza _ Oncologia Medica /ID# 125704, Monza

20141

Istituto Europeo di Oncologia /ID# 125702, Milan

21131

University of Alexandria /ID# 128337, Alexandria

21204

Institute For Pulmonary Diseas /ID# 128737, Kamenitz

22927

Lungen Clinic Grosshansdorf /ID# 126107, Großhansdorf

23502

Virginia Oncology Associates /ID# 127458, Norfolk

28050

Hospital Universitario HM Sanchinarro /ID# 125162, Madrid

28222

Hospital Universitario Puerta de Hierro Majadahonda /ID# 125160, Majadahonda

29200

CHRU de Brest - Hopital Morvan /ID# 127903, Brest

31000

Klinicki bolnicki centar Osijek /ID# 132214, Osijek

Centro Estatal de Cancerologia /ID# 127583, Chihuahua City

31059

Hopital Larrey - CHU de Toulouse /ID# 128394, Toulouse

32256

Cancer Specialists of North Florida - Southpoint /ID# 127815, Jacksonville

32610

University of Florida - Archer /ID# 126476, Gainesville

33308

Holy Cross Hospital /ID# 128074, Fort Lauderdale

33604

Hopital Haut-Lévêque /ID# 135270, Pessac

34098

Istanbul University-Cerrahpasa, Cerrahpasa Medical Faculty /ID# 126186, Istanbul

34125

Klinikum Kassel /ID# 127025, Kassel

34899

Marmara University Medical Fac /ID# 126187, Istanbul

35000

Opca bolnica Dr. Josip Bencevi /ID# 126539, Slavonski Brod

35033

Hospital Pontchaillou /ID# 126356, Rennes

35040

Ege University Medical Faculty /ID# 126189, Izmir

35110

Dr. Suat Seren Gogus Has /ID# 126190, Izmir

36011

Poltava Regional Clinical Oncology Centre of Poltava Regional Council /ID# 128223, Poltava

38138

The Jones Clinic, PC /ID# 124062, Germantown

40022

Municipal Non-Profit Enterprise of Sumy Regional Council Sumy Regional Clinical /ID# 128219, Sumy

41013

Hospital Universitario Virgen del Rocio /ID# 125207, Seville

41701

Appalachian Regional Healthcare, Inc (ARH) /ID# 128061, Hazard

43100

Azienda Ospedaliero Uni Parma /ID# 125703, Parma

44718

Gabrail Cancer Center Research /ID# 127415, Canton

46009

Fundacion Instituto Valenciano Oncologia IVO /ID# 125205, Valencia

46237

Franciscan St. Francis Health /ID# 126678, Indianapolis

46526

Goshen Center for Cancer Care /ID# 123875, Goshen

48202

Henry Ford Health System /ID# 126500, Detroit

48912

Sparrow Regional Cancer Center, Sparrow Health System /ID# 127156, Lansing

49102

Municipal Non-Profit Enterprise City Clinical Hospital No.4 of Dnipro City Counc /ID# 128217, Dnipro

50009

Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 127176, Kaunas

51014

Tartu University Hospital /ID# 127735, Tartu

52100

Opca bolnica Pula /ID# 126540, Pula

54603

Papageorgiou General Hospital Thessaloniki /ID# 125876, Nea Efkarpia

55131

Univ Johannes Gutenberg /ID# 125603, Mainz

55404

Minnesota Oncology Hematology, PA /ID# 127473, Minneapolis

58013

Regional Municipal Non-Profit Enterprise Bukovynian Clinical Oncology Center /ID# 128220, Chernivtsi

59045

CHRU Lille - Hôpital Claude Huriez /ID# 126353, Lille

60005

Illinois Cancer Specialists /ID# 127468, Arlington Heights

60099

Midwestern Regional CTC /ID# 126124, Zion

60201

NorthShore University HealthSystem - Evanston Hospital /ID# 128585, Evanston

60426

Ingalls Memorial Hosp /ID# 128360, Harvey

61070

Communal non-profit enterprise Regional Center of Oncology /ID# 128221, Kharkiv

65130

Vaasa Central Hospital /ID# 125896, Vaasa

68506

Nebraska Hematology Oncology /ID# 127699, Lincoln

68510

SE Nebraska Hema/Oncology Consultants P.C.d/b/a Southeast Nebraska Cancer Center /ID# 126477, Lincoln

70300

Assaf Harofeh Medical Center /ID# 127076, Be’er Ya‘aqov

71110

University General Hospital of Heraklion PA.G.N.I /ID# 125877, Heraklion

72037

Centre Hospitalier Le Mans /ID# 127902, Le Mans

72401

Northeast Arkansas Clinical Ch /ID# 128071, Jonesboro

74245

Klinik Loewenstein GmbH /ID# 126191, Löwenstein

75235

Parkland Health and Hosp Syste /ID# 128518, Dallas

75460

Texas Oncology - Paris /ID# 127484, Paris

76178

Cancerologia de Queretaro S.C. /ID# 125920, Querétaro City

76712

Texas Oncology - Waco /ID# 127459, Waco

77030

University of Texas MD Anderson Cancer Center /ID# 127946, Houston

78216

Hospital Angeles Centro Medico /ID# 127620, San Luis Potosí City

78705

Texas Oncology - Austin Midtown /ID# 127477, Austin

78745

Texas Oncology - South Austin /ID# 127476, Austin

79031

Lviv Oncological Regional Therapeutical and Diagnostic Centre /ID# 128218, Lviv

80045

VA Eastern Colorado Healthcare System /ID# 128065, Aurora

83100

AO San Giuseppe Moscati /ID# 125701, Avellino

83712

St. Luke's Mountain States Tumor Institute - Boise /ID# 124059, Boise

89169

Comprehensive Cancer Ctrs Neva /ID# 127491, Las Vegas

90017

LA Hem-Oncology Med Group /ID# 129178, Los Angeles

91120

Hadassah University Hospital /ID# 127077, Jerusalem

94000

Centre Hosp Intercommunal de Creteil /ID# 125922, Créteil

95029

Istituto Oncologico del Medite /ID# 132844, Viagrande

98684

Northwest Cancer Specialists, P.C. /ID# 127486, Vancouver

Northwest Cancer Specialists, P.C. /ID# 127488, Vancouver

115478

Federal State Budgetary Scientific Institution N.N. Blokhin Russian Cancer Resea /ID# 128458, Moscow

183047

"State Regional Budgetary Healthcare Institution Murmansk Regional Oncology Dis /ID# 128461", Murmansk

210603

Vitebsk Reg Clin Onc Disp /ID# 125516, Vitebsk

212018

Mogilev Reg Clin Oncology Dis /ID# 128639, Mogilev

213825

Bobruysk Interdistrict Onco. /ID# 128999, Babruysk

214009

Smolensk Regional Onc Clin Dis /ID# 127144, Smolensk

223040

State Institution Republican Scientific Practical Center of Oncology and Medica /ID# 125815, Lesnoy

224027

Brest Regional Hospital /ID# 125955, Brest

308010

Belgorod Oncology Dispensary /ID# 129899, Belgorod

400138

Volgograd Regional Clinical Oncology Dispensary /ID# 126350, Volgograd

430005

Ogarev Mordovia State Univ /ID# 127595, Saransk

460021

Orenburg Regional Clinical Onc /ID# 137474, Orenburg

620043

Sverdlovsk Regional Oncology Center Dispensary /ID# 128457, Yekaterinburg

634050

Cancer Research Institute Siberian Branch of the Russian Academy of Medical Scie /ID# 127143, Tomsk

664035

"State Budgetary Healthcare InstitutionIrkutsk Regional Oncology Center /ID# 128460", Irkutsk

4428164

Meir Medical Center /ID# 127078, Kfar Saba

5239424

Sheba Medical Center /ID# 127079, Ramat Gan

30322-1013

Winship Cancer Institute of Emory University /ID# 124061, Atlanta

03756

Dartmouth-Hitchcock Medical Center /ID# 128075, Lebanon

07601

Hackensack Univ Med Ctr /ID# 124057, Hackensack

75246-2003

Texas Oncology- Baylor Charles A. Sammons Cancer Center /ID# 128385, Dallas

75390-7208

UT Southwestern Medical Center /ID# 127876, Dallas

05401-1473

University of Vermont Medical Center /ID# 128064, Burlington

90610-000

Hospital Sao Lucas da PUCRS /ID# 127737, Porto Alegre

88301-220

Clinica de Neoplasias Litoral - Centro de Novos Tratamentos Itajai /ID# 127738, Itajaí

14784-400

Fundacao Pio XII - Hospital de Cancer de Barretos /ID# 126736, Barretos

20231-050

Instituto Nacional de Câncer José de Alencar Gomes da Silva (INCA) /ID# 127309, Rio de Janeiro

22793-080

Instituto COI de Educacao e Pesquisa /ID# 127739, Rio de Janeiro

01509-000

Fundacao Antonio Prudente - AC Camargo Cancer Center /ID# 126737, São Paulo

T2N 4Z6

University of Calgary /Id# 126326, Calgary

T6G 1Z2

Cross Cancer Institute /ID# 126154, Edmonton

L8V 1C3

Juravinski Cancer Clinic /ID# 126153, Hamilton

N6A 4L6

Victoria Hospital /ID# 126669, London

K1H 8L6

The Ottawa Hospital /ID# 126522, Ottawa

M5G 2M9

Princess Margaret Cancer Centre /ID# 126155, Toronto

H3G 1A4

McGill Univ HC /ID# 130431, Montreal

G1V 4G5

Iucpq-Ul /Id# 126524, Québec

G6V 3Z1

CSSS Alphonse-Desjardins, CHAU de Levis /ID# 126149, Québec

779 00

Fakultni Nemocnice Olomouc /ID# 125820, Olomouc

262 04

Nemocnice Na Plesi s.r.o. /ID# 125817, Nová Ves pod Pleší

697 01

Nemocnice Kyjov, prispevkova organizace /ID# 125819, Kyjov

741 01

Nemocnice Novy Jicin /ID# 125818, Nový Jičín

703 84

Vitkovicka nemocnice a. s. /ID# 127023, Ostrava

00290

Helsinki Univ Central Hospital /ID# 125897, Helsinki

06189

Centre Antoine Lacassagne /ID# 126360, Nice

D08 E9P6

St. James's Hospital /ID# 126177, Dublin

T12 E8YV

Cork University Hospital /ID# 126176, Cork

D09 XR63

Beaumont Hospital /ID# 126218, Dublin

V94F858

University Hospital Limerick /ID# 126175, Limerick

X91 ER8E

University Hospital Waterford /ID# 126178, Waterford

06100

Azienda Ospedaliera-Universitaria di Perugia-Divisione di Oncologia Medica. /ID# 125699, Perugia

LV-1002

P. Stradins Clinical Univ Hosp /ID# 126322, Riga

08660

National Cancer Institute /ID# 126323, Vilnius

5223 GZ

Jeroen Bosch Ziekenhuis /ID# 125709, 's-Hertogenbosch

1081 HV

Vrije Universiteit Medisch Centrum /ID# 125578, Amsterdam

4818 CK

Amphia Ziekenhuis /ID# 126466, Breda

5623 EJ

Catharina Ziekenhuis /ID# 125577, Eindhoven

3844 DG

Ziekenhuis St. Jansdal /ID# 125576, Harderwijk

6419 PC

Atrium-Orbis Zuyderland Medisch Centrum /ID# 125710, Heerlen

8025 AB

Isala /ID# 125579, Zwolle

0310

Oslo Universitetssykehus, Radiumhospitalet /ID# 126335, Oslo

35-021

Mrukmed. Lekarz Beata Madej Mruk i Partner /ID# 126548, Rzeszów

81-519

Szpital Morski im. PCK /ID# 126547, Gdynia

04-125

NZOZ Magodent Ctr. Med. Ostro /ID# 126545, Warsaw

05-135

Mazowiecki Szpital Onkologiczn /ID# 126546, Wieliszew

4835-044

Hospital Senhora da Oliveira de Guimaraes, EPE /ID# 126761, Guimarães

4710-243

CCA Braga - Hospital de Braga /ID# 125837, Braga

3000-075

Ctr Hosp Univ Coimbra, EPE /ID# 125838, Coimbra

1769-001

Hospital Pulido Valente /ID# 125835, Lisbon

4200-072

IPO Porto FG, EPE /ID# 125836, Porto

4200-319

Centro Hospitalar de Sao Joao, EPE /ID# 125875, Porto

00921-3201

VA Caribbean Healthcare System /ID# 124562, San Juan

821 01

Univerzitna Nemocnica Bratislava /ID# 126342, Bratislava

921 01

MEDEON, s.r.o. /ID# 128517, Pieštany

0001

University of Pretoria /ID# 127297, Pretoria

0044

Dr Albert, Bouwer and Jordaan Incorporated /ID# 126098, Pretoria

0181

Mary Potter Oncology Centre /ID# 126099, Pretoria

08907

Hospital Duran i Reynals /ID# 125161, L'Hospitalet de Llobregat

08035

Hospital Universitario Vall d'Hebron /ID# 125159, Barcelona

803 24

Gavle Sjukhus /ID# 126444, Gävle

413 45

Sahlgrenska University Hosp /ID# 129997, Gothenburg

581 85

University Hospital Linkoping /ID# 126443, Linköping

07059

Akdeniz University Medical Fac /ID# 126997, Antalya

GL53 7AN

Cheltenham General Hospital /ID# 125692, Cheltenham

SE1 9RT

Guy's and St Thomas' NHS Found /ID# 125694, London

NR4 7UY

Norfolk and Norwich Univ Hosp /ID# 125697, Norwich

LL57 2PW

Betsi Cadwaladr Univ Health Bo /ID# 127177, Bangor

ES31 4JB

North Devon District Hospital /ID# 125689, Barnstaple

BH7 7DW

The Royal Bournemouth Hospital /ID# 125690, Bournemouth

CT1 3NG

East Kent Hosp Univ NHS Trust /ID# 125698, Canterbury

G12 0YN

Gartnavel General Hospital /ID# 126233, Glasgow

NR31 6LA

James Paget University Hosp /ID# 125696, Great Yarmouth

W6 8RF

Charing Cross Hospital /ID# 125688, London

ME16 9QQ

Maidstone Hospital /ID# 125693, Maidstone

CH63 4JY

The Clatterbridge Cancer Ctr /ID# 125695, Metropolitan Borough of Wirral

NE7 7DN

The Newcastle Upon Tyne Hospitals NHS Foundation Trust Freeman Hospital /ID# 129228, Newcastle upon Tyne

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