Efficacy and Safety of Mepolizumab as an Add-on Treatment in Chronic Obstructive Pulmonary Disease (COPD)

PHASE3CompletedINTERVENTIONAL
Enrollment

674

Participants

Timeline

Start Date

April 24, 2014

Primary Completion Date

January 16, 2017

Study Completion Date

January 16, 2017

Conditions
Pulmonary Disease, Chronic Obstructive
Interventions
DRUG

Mepolizumab

Humanised IgG antibody (IgG1, kappa) with human heavy and light chain frameworks, provided as a lyophilised cake in sterile vial. Vial to be reconstituted with Sterile Water for Injection, just prior to use.

DRUG

Placebo

Sterile 0.9percent sodium chloride solution

Trial Locations (169)

220

GSK Investigational Site, Taipei

333

GSK Investigational Site, Tau-Yuan County

404

GSK Investigational Site, Taichung

824

GSK Investigational Site, Kaohsiung City

1886

GSK Investigational Site, Berazategui

1900

GSK Investigational Site, La Plata

2035

GSK Investigational Site, Maroubra

2400

GSK Investigational Site, København NV

2450

GSK Investigational Site, Coffs Harbour

2650

GSK Investigational Site, Hvidovre

5000

GSK Investigational Site, Odense C

5500

GSK Investigational Site, Mendoza

6150

GSK Investigational Site, Murdoch

7600

GSK Investigational Site, Mar del Plata

8000

GSK Investigational Site, Aarhus C

10717

GSK Investigational Site, Berlin

12157

GSK Investigational Site, Berlin

12203

GSK Investigational Site, Berlin

15562

GSK Investigational Site, Rüdersdorf

17033

GSK Investigational Site, Hershey

19140

GSK Investigational Site, Philadelphia

19456

GSK Investigational Site, Oaks

21018

GSK Investigational Site, Vinnytsia

22299

GSK Investigational Site, Hamburg

23225

GSK Investigational Site, Richmond

23249

GSK Investigational Site, Richmond

23552

GSK Investigational Site, Lübeck

26505

GSK Investigational Site, Morgantown

28054

GSK Investigational Site, Gastonia

28078

GSK Investigational Site, Huntersville

28207

GSK Investigational Site, Charlotte

29464

GSK Investigational Site, Mt. Pleasant

29615

GSK Investigational Site, Greenville

29640

GSK Investigational Site, Easley

29732

GSK Investigational Site, Rock Hill

30096

GSK Investigational Site, Duluth

30103

GSK Investigational Site, Adairsville

30173

GSK Investigational Site, Hanover

30189

GSK Investigational Site, Woodstock

32132

GSK Investigational Site, Edgewater

32608

GSK Investigational Site, Gainesville

32720

GSK Investigational Site, DeLand

32825

GSK Investigational Site, Orlando

33436

GSK Investigational Site, Boynton Beach

33704

GSK Investigational Site, St. Petersburg

35294

GSK Investigational Site, Birmingham

36608

GSK Investigational Site, Mobile

39112

GSK Investigational Site, Magdeburg

42101

GSK Investigational Site, Bowling Green

43213

GSK Investigational Site, Columbus

49051

GSK Investigational Site, Dnipropetrovsk

54003

GSK Investigational Site, Mykolayiv

55131

GSK Investigational Site, Mainz

60389

GSK Investigational Site, Frankfurt am Main

60596

GSK Investigational Site, Frankfurt am Main

61035

GSK Investigational Site, Kharkiv

61124

GSK Investigational Site, Kharkiv

63263

GSK Investigational Site, Neu-Isenburg

70378

GSK Investigational Site, Stuttgart

76104

GSK Investigational Site, Fort Worth

80023

GSK Investigational Site, Broomfield

83814

GSK Investigational Site, Coeur d'Alene

87108

GSK Investigational Site, Albuquerque

91786

GSK Investigational Site, Upland

92506

GSK Investigational Site, Riverside

97220

GSK Investigational Site, Portland

100024

GSK Investigational Site, Ploieşti

110084

GSK Investigational Site, Piteşti

200642

GSK Investigational Site, Craiova

300310

GSK Investigational Site, Timișoara

400371

GSK Investigational Site, Cluj-Napoca

505100

GSK Investigational Site, Codlea

620043

GSK Investigational Site, Focşani

700115

GSK Investigational Site, Iași

2341131

GSK Investigational Site, Valparaíso

3460001

GSK Investigational Site, Talca

7500692

GSK Investigational Site, Santiago

7500698

GSK Investigational Site, Santiago

7860406

GSK Investigational Site, Santiago

8242238

GSK Investigational Site, Santiago

8380453

GSK Investigational Site, Santiago

06902

GSK Investigational Site, Stamford

29406-7108

GSK Investigational Site, Charleston

B8000AAK

GSK Investigational Site, Bahía Blanca

C1414AIF

GSK Investigational Site, Ciudad Autonoma de Buenos Aires

C1121ABE

GSK Investigational Site, Buenos Aires

C1425BEN

GSK Investigational Site, Buenos Aires

M5500CCG

GSK Investigational Site, Mendoza

B2N 1L2

GSK Investigational Site, Truro

L7N 3V2

GSK Investigational Site, Burlington

M5T 3A9

GSK Investigational Site, Toronto

N8X 5A6

GSK Investigational Site, Windsor

J6E 2B4

GSK Investigational Site, Saint-Charles-Borromée

G8T 7A1

GSK Investigational Site, Trois-Rivières

01307

GSK Investigational Site, Dresden

04357

GSK Investigational Site, Leipzig

791-0281

GSK Investigational Site, Ehime

910-1193

GSK Investigational Site, Fukui

811-1394

GSK Investigational Site, Fukuoka

960-1295

GSK Investigational Site, Fukushima

509-6134

GSK Investigational Site, Gifu

722-8503

GSK Investigational Site, Hiroshima

734-8530

GSK Investigational Site, Hiroshima

053-8506

GSK Investigational Site, Hokkaido

650-0047

GSK Investigational Site, Hyōgo

762-8550

GSK Investigational Site, Kagawa

227-8501

GSK Investigational Site, Kanagawa

861-1196

GSK Investigational Site, Kumamoto

515-8544

GSK Investigational Site, Mie

980-8574

GSK Investigational Site, Miyagi

983-8520

GSK Investigational Site, Miyagi

986-8522

GSK Investigational Site, Miyagi

702-8055

GSK Investigational Site, Okayama

711-0921

GSK Investigational Site, Okayama

901-2121

GSK Investigational Site, Okinawa

573-0153

GSK Investigational Site, Osaka

589-8511

GSK Investigational Site, Osaka

591-8555

GSK Investigational Site, Osaka

876-0813

GSK Investigational Site, Ōita

693-8501

GSK Investigational Site, Shimane

436-0022

GSK Investigational Site, Shizuoka

438-8550

GSK Investigational Site, Shizuoka

103-0027

GSK Investigational Site, Tokyo

104-8560

GSK Investigational Site, Tokyo

136-0075

GSK Investigational Site, Tokyo

142-8666

GSK Investigational Site, Tokyo

152-0021

GSK Investigational Site, Tokyo

204-8585

GSK Investigational Site, Tokyo

5223 GZ

GSK Investigational Site, 's-Hertogenbosch

7609 PP

GSK Investigational Site, Almelo

4818 CK

GSK Investigational Site, Breda

9713 GZ

GSK Investigational Site, Groningen

2134 TM

GSK Investigational Site, Hoofddorp

6085 NM

GSK Investigational Site, Horn

2333 ZA

GSK Investigational Site, Leiden

6162 BG

GSK Investigational Site, Sittard-geleen

3584 CX

GSK Investigational Site, Utrecht

7207 AE

GSK Investigational Site, Zutphen

020125

GSK Investigational Site, Bucharest

050159

GSK Investigational Site, Bucharest

066 01

GSK Investigational Site, Humenné

058 01

GSK Investigational Site, Poprad

052 01

GSK Investigational Site, Spišská Nová Ves

927 01

GSK Investigational Site, Šaľa

952 01

GSK Investigational Site, Vráble

431-070

GSK Investigational Site, Anyang-Si Gyeonggi-do

420-767

GSK Investigational Site, Bucheon City, Gyenggi-do

602-715

GSK Investigational Site, Busan

361-711

GSK Investigational Site, Cheongju, Chungcheongbuk-do

705-703

GSK Investigational Site, Daegu

403-720

GSK Investigational Site, Incheon

561-712

GSK Investigational Site, Jeonju

120-752

GSK Investigational Site, Seoul

130-709

GSK Investigational Site, Seoul

130-872

GSK Investigational Site, Seoul

138-736

GSK Investigational Site, Seoul

140-743

GSK Investigational Site, Seoul

Unknown

GSK Investigational Site, Seoul

GSK Investigational Site, Taipei

220-701

GSK Investigational Site, Wonju-si, Kanwon-do

03680

GSK Investigational Site, Kiev

GSK Investigational Site, Kyiv

03038

GSK Investigational Site, Kyiv

BD9 6RJ

GSK Investigational Site, Bradford

CB2 0QQ

GSK Investigational Site, Cambridge

OX3 7LE

GSK Investigational Site, Oxford

PL6 8DH

GSK Investigational Site, Plymouth

S5 7AU

GSK Investigational Site, Sheffield

SG1 4AB

GSK Investigational Site, Stevenage

Sponsors

Lead Sponsor

All Listed Sponsors
lead

GlaxoSmithKline

INDUSTRY

NCT02105961 - Efficacy and Safety of Mepolizumab as an Add-on Treatment in Chronic Obstructive Pulmonary Disease (COPD) | Biotech Hunter | Biotech Hunter