My Pathway: A Study Evaluating Herceptin/Perjeta, Tarceva, Zelboraf/Cotellic, Erivedge, Alecensa, and Tecentriq Treatment Targeted Against Certain Molecular Alterations in Participants With Advanced Solid Tumors

PHASE2CompletedINTERVENTIONAL
Enrollment

673

Participants

Timeline

Start Date

April 14, 2014

Primary Completion Date

May 24, 2023

Study Completion Date

May 24, 2023

Conditions
NeoplasmsSolid TumorsBiliary CancerSalivary CancerBladder Cancer
Interventions
DRUG

Trastuzumab

Trastuzumab will be administered as per the schedule specified in the respective arm, until tumor progression or occurrence of unacceptable toxicity.

DRUG

Pertuzumab

Pertuzumab will be administered as per the schedule specified in the respective arm, until tumor progression or occurrence of unacceptable toxicity.

DRUG

Erlotinib

Erlotinib will be administered as per the schedule specified in the respective arm, until tumor progression or occurrence of unacceptable toxicity.

DRUG

Vemurafenib

Vemurafenib will be administered as per the schedule specified in the respective arm, until tumor progression or occurrence of unacceptable toxicity.

DRUG

Cobimetinib

Cobimetinib will be administered as per the schedule specified in the respective arm, until tumor progression or occurrence of unacceptable toxicity.

DRUG

Vismodegib

Vismodegib will be administered as per the schedule specified in the respective arm, until tumor progression or occurrence of unacceptable toxicity.

DRUG

Alectinib

Alectinib will be administered as per the schedule specified in the respective arm, until tumor progression or occurrence of unacceptable toxicity.

DRUG

Atezolizumab

Atezolizumab will be administered as per the schedule specified in the respective arm, until tumor progression or occurrence of unacceptable toxicity.

Trial Locations (60)

10021

Weill Cornell Univ Medical Ctr; Breast Cancer Center, New York

10032

Herbert Irving Comprehensive Cancer Center; Herbert Irving Pavillion, New York

10065

Memorial Sloan Kettering Cancer Center, New York

10604

Memorial Sloan Kettering Cancer Center at Westchester, Harrison

15232

UPMC - Hillman Cancer Center, Pittsburgh

19090

Abington Mem Hosp-Abington; Rose. Can Ctr,Gyn Onc Ins, Willow Grove

19104

Abramson Cancer Center, Philadelphia

19107

Thomas Jefferson University Hospital, Philadelphia

19124

Eastern Regional Medical Ctr, Philadelphia

21287

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore

23229

Virginia Cancer Institute, Richmond

27157

Wake Forest Univ Health Svcs; Internal Medicine, Winston-Salem

27710

Duke University Medical Center, Durham

30265

Southeastern Regional Medical Center, Inc., Newnan

30501

Northeast Georgia Medical Center; Oncology Research Dept-5C, Gainesville

30607

University Cancer & Blood Center, LLC; Research, Athens

32224

Mayo Clinic, Jacksonville

32804

Florida Hospital Cancer Inst; Memorial System Onc Clin Rsch, Orlando

33401

Florida Cancer Specialists, Research Department, West Palm Beach

33705

Florida Cancer Specialist, North Region, St. Petersburg

33916

SCRI Florida Cancer Specialists South, Fort Myers

37203

Tennessee Oncology - Nashville, Nashville

37232

Vanderbilt Ingram Cancer Clinic, Nashville

37404

Sarah Cannon Research Institute / Tennessee Oncology, Chattanooga

37920

Tennessee Cancer Specialists, Knoxville

38138

West Clinic, Germantown

44106

Cleveland Clinic, Cleveland

University Hospitals of Cleveland, Cleveland

45242

Oncology Hematology Care Inc, Cincinnati

53226

Medical College of Wisconsin, Milwaukee

53705

University of Wisconsin, Madison

55905

Mayo Foundation, Rochester

57104

Sanford Cancer Cnt Onco Clinic, Sioux Falls

58102

Sanford Roger Maris Cancer Center, Fargo

60099

Midwestern Regional Med Center, Zion

60611

Northwestern University; Robert H. Lurie Comp Can Ctr; Northwestern Medicine Development Inst, Chicago

60637

University Of Chicago Medical Center; Section Of Hematology/Oncology, Chicago

64132

Research Medical Center - Antibiotic Research Associates, Inc., Kansas City

72762

Highlands Oncology Group, Springdale

73104

University of Oklahoma Health Sciences Center, Oklahoma City

76104

The Center for Cancer and Blood Disorders - Fort Worth, Fort Worth

77030

MD Anderson, Houston

85259

Mayo Clinic Arizona, Phoenix

85338

Western Regional Medical Center at Cancer Treatment Centers of America, Goodyear

87102

University of New Mexico Comprehensive Cancer Center, Albuquerque

87106

University of New Mexico Comprehensive Cancer Center - Albuquerque Cedar Street; Drug Shipment, Albuquerque

87109

University of New Mexico Comprehensive Cancer Center - Albuquerque Lang NE; Drug Shipment, Albuquerque

87131

University of New Mexico, Albuquerque

87401

San Juan Oncology Associates, Farmington

90230

Science 37, Inc, Culver City

91010

City of Hope Comprehensive Cancer Center, Duarte

92270

Eisenhower Medical Center, Rancho Mirage

94305

Stanford Comprehensive Cancer Center, Stanford

94589

Kaiser Permanente - Vallejo, Vallejo

97213

Providence Portland Medical Center, Portland

98405

Northwest Medical Specialties, Tacoma

92093-0698

Moores UCSD Cancer Center; Dept Clinical Trials Office, La Jolla

80045-2517

University of Colorado, Aurora

07748

Memorial Sloan Kettering - Monmouth, Middletown

27599-7305v

Univ No Carolina School of Med; Physicians Office Bldg, Chapel Hill

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Genentech, Inc.

INDUSTRY