SARC024: A Blanket Protocol to Study Oral Regorafenib in Patients With Selected Sarcoma Subtypes

PHASE2CompletedINTERVENTIONAL
Enrollment

131

Participants

Timeline

Start Date

July 31, 2014

Primary Completion Date

May 31, 2022

Study Completion Date

May 31, 2022

Conditions
LiposarcomaOsteogenic SarcomaEwing/Ewing-like SarcomaRhabdomyosarcomaMesenchymal Chondrosarcoma
Interventions
DRUG

Regorafenib

Adults: 160 mg daily; 21 days on and 7 days off Pediatrics: 82mg/m2 (rounding to the nearest 20mg) daily; 21 days on and 7 days off

DRUG

Placebo

21 days on and 7 days off

Trial Locations (18)

27705

Duke University, Durham

28203

Carolinas Healthcare System, Charlotte

32224

Mayo Clinic - Florida, Jacksonville

33612

H. Lee Moffitt, Tampa

37232

Vanderbilt University, Nashville

43202

Ohio State University, Columbus

46202

Indiana University, Indianapolis

55905

Mayo Clinic - Minnesota, Rochester

60611

Northwestern University, Chicago

77030

Texas Children's Hospital, Houston

84112

Huntsman Cancer Institute, Salt Lake City

90027

Children's Hospital Los Angeles, Los Angeles

90403

Sarcoma Oncology Research Center, Santa Monica

91010

City of Hope National Medical Center, Duarte

94305

Stanford University, Stanford

97239

Oregon Health and Science University, Portland

98109

Seattle Cancer Care Alliance, Seattle

02215

Dana Farber/Partners Cancer Care, Boston

All Listed Sponsors
lead

Sarcoma Alliance for Research through Collaboration

OTHER

NCT02048371 - SARC024: A Blanket Protocol to Study Oral Regorafenib in Patients With Selected Sarcoma Subtypes | Biotech Hunter | Biotech Hunter