162
Participants
Start Date
March 4, 2014
Primary Completion Date
August 4, 2016
Study Completion Date
August 4, 2016
Tocilizumab
Tocilizumab 162 mg will be administered once a week by SC injection and as a single fixed dose, irrespective of body weight, for the treatment duration of 52 weeks.
DMARDs
Treatment with non-biologic DMARDs, at a stable dose that was initiated at least 4 weeks prior to baseline, is permitted during the study. The study protocol does not specify any particular therapy.
Oral Corticosteroids
Stable oral corticosteroids doses (≤10 mg/day prednisone or equivalent) are allowed. The study protocol does not specify any additional detail on types of oral corticosteroids.
Methotrexate
Methotrexate per investigator's discretion.
Aberdeen Royal Infirmary, Aberdeen
Christchurch Hospital; Rheumatology, Bournemouth
Royal Sussex County Hospital; Clinical Investigation Research Unit, Brighton
Queens Hospital, Burton-on-Trent
West Suffolk Hospital, Bury Saint Edmonds
Addenbrooke'S Hospital; Rheumatology Research Unit, Cambridge
Cannock Chase Hospital; Rheumatology, Cannock
University Hospital of Wales; Dept of Rhematology, Cardiff
Broomfield Hospital, Chelmsford
Countess of Chester Hospital; Dept of Rheumatology, Chester
Dewsbury & District Hospital; Dept of Rheumatology, Dewsbury
Russells Hall Hospital; Rheumatology Department, Dudley
Ninewells Hospital, Dundee
Eastbourne District General Hospital; Dept of Rheumatology, Eastbourne
Western General Hospital; Pharmacy Department, Edinburgh
Gartnavel General Hospital; Rheumatology, Glasgow
Diana Princess of Wales Hosp., Grimsby
Princess Alexandra Hospital, Harlow
Northwick Park Hospital, Harrow
Hemel Hempstead General Hospital; Rheumatology Dept, Hemel Hempstead
Hull Royal Infirmary; Rheumatology Department, Hull
Llandudno General Hospital, Llandudno
Whipps Cross Hospital; Rheumatology Dept, London
Royal Free Hospital; Department of Rheumatology, London
Maidstone Hospital; Dept of Rheumatology, Maidstone
Wythenshawe Hospital, Manchester
Freeman Hospital; Dept of Rheumatology, Newcastle upon Tyne
North Tyneside General Hospital, North Shields
Norfolk & Norwich Hospital; Rheumatology, Norwich
Integrated Care Centre, Oldham
Solihull Hospital, Solihull
Haywood Hospital; Staffordshire Rheumatology Centre, Stoke-on-Trent
Great Western Hospital; Dept of Rheumatology, Swindon
Torbay Hospital; Dept of Rhematology, Torquay
Royal Cornwall Hospital; Rhuematololgy Dept, Truro
Warrington Hospital, Warrington
Wrightington Hospital; Rheumatology, Wigan
Wishaw General Hospital, Wishaw
Hoffmann-La Roche
INDUSTRY