Multicenter Prospective Cohort Study on Current Treatments of Legg-Calvé-Perthes Disease

Enrolling by invitationOBSERVATIONAL
Enrollment

1,500

Participants

Timeline

Start Date

August 31, 2012

Primary Completion Date

September 30, 2032

Study Completion Date

September 30, 2032

Conditions
Legg Calve Perthes Disease
Interventions
PROCEDURE

Osteotomy + Long Term Non-Weight Bearing

Surgical procedure that improves femoral head containment, plus a post-operative protocol that requires patient to maintain non-weight bearing for 6 months.

PROCEDURE

Osteotomy + Short Term Non-Weight Bearing

Surgical procedure that improves femoral head containment, plus a post-operative protocol that allows early return to function after 6 weeks of non-weight bearing.

PROCEDURE

Nonoperative Observation

Group will not undergo any surgical or invasive procedures during course of treatment.

PROCEDURE

Multiple Epiphyseal Drilling

Multiple epiphyseal drilling is a procedure that creates small holes in the femoral head growth plate to increase blood flow into the femoral head.

Trial Locations (46)

5006

Women and Children's Hospital of Adelaide, Adelaide

10003

NYU Langone/Hospital for Joint Disease, New York

10032

New York Presbyterian Hospital (Columbia Campus), New York

10467

Children's Hospital at Montefiore, The Bronx

19104

Children's Hospital of Philadelphia, Philadelphia

19803

Alfred I. DuPont Hospital for Children of the Nemours Foundation, Wilmington

20010

Children's National Medical Center, Washington D.C.

21218

Johns Hopkins, Baltimore

22763

Children's Hospital Hamburg-Altona, Hamburg

23538

Hospital of Schleswig-Holstein, Lübeck

28207

OrthoCarolina, Charlotte

30342

Children's Orthopaedics of Atlanta, Atlanta

35294

Children's Hospital of Alabama, Birmingham

38138

University of Tennessee-Campbell Clinic, Germantown

43205

Nationwide Children's Hospital, Columbus

45229

Cincinnati Children's Hospital Medical Center, Cincinnati

55101

Gillette Children's Specialty Healthcare, Saint Paul

55905

Mayo Clinic, Rochester

60611

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago

73104

Oklahoma University Health Science Center, Oklahoma City

75219

Texas Scottish Rite Hospital for Children, Dallas

77030

Texas Children's Hospital, Houston

80045

Children's Hospital Colorado, Aurora

85016

Tianjin Hospital Pediatric Orthopedics, Tianjin

90027

Children's Hospital of Los Angeles, Los Angeles

Kaiser Permanente Hospital, Los Angeles

92024

Rady Children's Hospital California, San Diego

94158

UCSF Benioff Children's Hospitals, San Francisco

97239

Oregon Health and Science University, Portland

98105

Seattle Children's Hospital, Seattle

06106

Connecticut Children's Medical Center, Hartford

02115-5724

Children's Hospital Boston, Boston

05508-070

Universidade de São Paulo, São Paulo

T3B6A8

Alberta Children's Hospital, Division of Paediatric Surgery, Calgary

V6H 3V4

British Columbia Children's Hospital, Vancouver

Unknown

University Hospital of Schleswig-Holstein (Campus Lubeck), Lübeck

Kasturba Medical College (KMC), Manipal, Udupi

Children's Health Ireland at Temple Street, Dublin

Medical University of Lodz, Lodz

Hospital Infantil Universitario Nino Jesus, Madrid

Uppsala University, Uppsala

Centre hopsitalier universitaire Vaudois, Lausanne

Alder Hey Children's Hosopital (University of Oxford), Liverpool

0372

Oslo University Hospital, Oslo

00912

San Jorge Children's Hospital, San Juan

SO166YD

Southampton Children's Hospital, Southampton

All Listed Sponsors
collaborator

Alberta Children's Hospital

OTHER

collaborator

Alfred I. duPont Hospital for Children

OTHER

collaborator

Le Bonheur Children's Hospital

OTHER

collaborator

Children's Hospital Colorado

OTHER

collaborator

Children's Hospital Los Angeles

OTHER

collaborator

Children's National Research Institute

OTHER

collaborator

Children's Healthcare of Atlanta

OTHER

collaborator

Children's Hospital of Philadelphia

OTHER

collaborator

Children's Hospital Medical Center, Cincinnati

OTHER

collaborator

Columbia University

OTHER

collaborator

Connecticut Children's Medical Center

OTHER

collaborator

Gillette Children's Specialty Healthcare

OTHER

collaborator

Boston Children's Hospital

OTHER

collaborator

Johns Hopkins University

OTHER

collaborator

Kaiser Permanente

OTHER

collaborator

Kasturba Medical College

OTHER

collaborator

Montefiore Medical Center

OTHER

collaborator

Nationwide Children's Hospital

OTHER

collaborator

NYU Langone Health

OTHER

collaborator

OrthoCarolina Research Institute, Inc.

OTHER

collaborator

University of Sao Paulo General Hospital

OTHER

collaborator

Seoul National University Childrens Hospital

OTHER

collaborator

Shriners Hospitals for Children

OTHER

collaborator

University Hospital Southampton NHS Foundation Trust

OTHER

collaborator

Baylor College of Medicine

OTHER

collaborator

Universitätsklinikum Hamburg-Eppendorf

OTHER

collaborator

Ann & Robert H Lurie Children's Hospital of Chicago

OTHER

collaborator

British Columbia Children's Hospital

OTHER

collaborator

Children's of Alabama

OTHER

collaborator

Hospital Infantil Universitario Niño Jesús, Madrid, Spain

OTHER

collaborator

University of Oklahoma

OTHER

collaborator

Oregon Health and Science University

OTHER

collaborator

Rady Children's Hospital, San Diego

OTHER

collaborator

San Jorge Children's Hospital (Puerto Rico)

UNKNOWN

collaborator

University College Dublin

OTHER

collaborator

Tianjin Children's Hospital

OTHER

collaborator

University Hospital Schleswig-Holstein

OTHER

collaborator

University of California, San Francisco

OTHER

collaborator

University of Haifa

OTHER

collaborator

Uppsala University

OTHER

collaborator

Medical University of Lodz

OTHER

collaborator

Oslo University Hospital

OTHER

collaborator

Seattle Children's Hospital

OTHER

collaborator

Mayo Clinic

OTHER

lead

Texas Scottish Rite Hospital for Children

OTHER