Study to Evaluate Treatment of Dabrafenib Plus Trametinib in Subjects With BRAF Mutation-Positive Melanoma That Has Metastasized to the Brain

PHASE2CompletedINTERVENTIONAL
Enrollment

127

Participants

Timeline

Start Date

February 21, 2014

Primary Completion Date

May 12, 2017

Study Completion Date

February 14, 2018

Conditions
Melanoma and Brain Metastases
Interventions
DRUG

Dabrafenib

Dabrafenib will be provided as 50 mg and 75 mg capsules

DRUG

Trametinib

Trametinib will be provided as 0.5 mg and 2.0 mg tablets

Trial Locations (47)

2060

Novartis Investigative Site, North Sydney

3004

Novartis Investigative Site, Melbourne

4120

Novartis Investigative Site, Greenslopes

13385

Novartis Investigative Site, Marseille

15232

Novartis Investigative Site, Pittsburgh

20133

Novartis Investigative Site, Milan

20141

Novartis Investigative Site, Milan

24105

Novartis Investigative Site, Kiel

27599

Novartis Investigative Site, Chapel Hill

28007

Novartis Investigative Site, Madrid

29010

Novartis Investigative Site, Málaga

30322

Novartis Investigative Site, Atlanta

30341

Novartis Investigative Site, Atlanta

30449

Novartis Investigative Site, Hanover

31008

Novartis Investigative Site, Pamplona

31052

Novartis Investigative Site, Toulouse

34295

Novartis Investigative Site, Montpellier

35016

Novartis Investigative Site, Las Palmas de Gran Canaria

35042

Novartis Investigative Site, Rennes

35128

Novartis Investigative Site, Padua

35243

Novartis Investigative Site, Birmingham

37232

Novartis Investigative Site, Nashville

43210

Novartis Investigative Site, Columbus

44093

Novartis Investigative Site, Nantes

46009

Novartis Investigative Site, Valencia

50009

Novartis Investigative Site, Zaragoza

50937

Novartis Investigative Site, Cologne

59037

Novartis Investigative Site, Lille

69120

Novartis Investigative Site, Heidelberg

69495

Novartis Investigative Site, Pierre-Bénite

72076

Novartis Investigative Site, Tübingen

75475

Novartis Investigative Site, Paris

77030

Novartis Investigative Site, Houston

80045

Novartis Investigative Site, Aurora

80337

Novartis Investigative Site, Munich

86021

Novartis Investigative Site, Poitiers

92100

Novartis Investigative Site, Boulogne-Billancourt

94115

Novartis Investigative Site, San Francisco

94805

Novartis Investigative Site, Villejuif

02215

Novartis Investigative Site, Boston

T6G 1Z2

Novartis Investigative Site, Edmonton

L8V 5C2

Novartis Investigative Site, Hamilton

M5G 2M9

Novartis Investigative Site, Toronto

H2W 1S6

Novartis Investigative Site, Montreal

07548

Novartis Investigative Site, Gera

08036

Novartis Investigative Site, Barcelona

07198

Novartis Investigative Site, Palma de Mallorca

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY