A Phase 2, 2-Stage, 2-Cohort Study of Talazoparib (BMN 673), in Locally Advanced and/or Metastatic Breast Cancer Patients With BRCA Mutation (ABRAZO Study)

PHASE2TerminatedINTERVENTIONAL
Enrollment

84

Participants

Timeline

Start Date

December 13, 2013

Primary Completion Date

September 1, 2016

Study Completion Date

October 31, 2018

Conditions
Breast NeoplasmsBRCA 1 Gene MutationBRCA 2 Gene Mutation
Interventions
DRUG

talazoparib

Trial Locations (71)

10065

Memorial Sloan Kettering Evelyn H. Lauder Breast Center, New York

Memorial Sloan-Kettering Cancer Center, New York

11570

Memorial Sloan Kettering Rockville Centre, Rockville Centre

13125

Helios Klinikum Berlin-Buch, Berlin

15006

Complejo Hospitalario Universitario A Coruna, A Coruña

18435

g.SUND Gynaekologie Kompetenzzentrum Stralsund, Stralsund

21093

Sidney Kimmel Comprehensive Cancer Center (SKCCC) at Johns Hopkins, Green Spring Station, Lutherville

21231

Sidney Kimmel Comprehensive Cancer Center (SKCCC) at Johns Hopkins, Baltimore

21401

Anne Arundel Medical Center (AAMC), Annapolis Oncology and Hematology, Annapolis

Anne Arundel Medical Center (AAMC), Research Pharmacy, Annapolis

Anne Arundel Medical Center (AAMC), Annapolis

23007

Complejo Hospitalario de Jaen, Jaén

24105

Universitaetsklinikum Schleswig-Holstein, Kiel

28007

Hospital General Universitario Gregorio Maranon, Madrid

28033

MD Anderson Cancer Center International Espana, Madrid

28040

Hospital Clinico San Carlos, Madrid

33021

Memorial Cancer Institute at Memorial Regional Hospital, Hollywood

Memorial Regional Hospital, Hollywood

33028

Memorial Breast Cancer Center at Memorial Hospital West, Pembroke Pines

Memorial Cancer Institute at Memorial Hospital West, Pembroke Pines

Memorial Hospital West, Pembroke Pines

33136

University of Miami Hospital & Clinics, Miami

33324

Sylvester at Plantation, Plantation

33442

Sylvester at Deerfield Beach, Deerfield Beach

37044

CHU Bretonneau Centre Henry Kaplan, Tours

37203

Tennessee Oncology, PLLC, Nashville

The Sarah Cannon Research Institute, Nashville

37920

University of Tennessee Medical Center, Knoxville

40225

University Hospital Duesseldorf, Düsseldorf

41009

Hospital Universitario Virgen Macarena, Seville

45136

Kliniken Essen Mitte Klinik fuer Gynaekologie und Gynaekologische Onkologie, Essen

46202

Indiana University Health Melvin and Bren Simon Cancer Center, Indianapolis

Investigational Drug Services, Indianapolis

IU Health University Hospital, Indianapolis

Sidney & Lois Eskenazi Hospital, Indianapolis

46290

Springmill Medical Clinic, Indianapolis

50009

Hospital Universitario Miguel Servet, Zaragoza

54290

Klinikum Mutterhaus Der Borromaeerinnen Ggmbh, Trier

59020

Centre Oscar Lambret, Lille Cédex

69373

Centre Leon Berard, Lyon

72076

Universitaets-Frauenklinik, Tübingen

80336

IOZ Muenchen - lnerdisziplinaeres Onkologisches Zentrum, Munich

81377

University of Munich (LMU) Grosshadern Hospital, Munich

81675

Klinikum rechts der Isar der TU Muenchen, Munich

90095

TRIO-US Central Administration, Los Angeles

90277

Torrance Health Association, DBA Torrance Memorial Physician Network/Cancer Care Associates, Redondo Beach

90404

UCLA Hematology-Oncology, Santa Monica

91054

Universitaetsklinikum Erlangen, Erlangen

91326

UCLA Hematology Oncology- Porter Ranch, Porter Ranch

94115

University of California, San Francisco: Helen Diller Comprehensive Cancer Center, San Francisco

94304

Stanford Women's Cancer Center, Palo Alto

94305

Stanford Cancer Institute, Stanford

Stanford Hospital and Clinics, Stanford

94904

Marin Cancer Care, Inc., Greenbrae

90095-1772

UCLA West Medical Pharmacy Attn: Steven L. Wong, PharmD, Los Angeles

90095-7349

UCLA West Medical Pharmacy, Attn: Steven L. Wong, Pharm.D., Los Angeles

46202-5116

ICRC, Indianapolis

77030-4009

The University of Texas MD Anderson Cancer Center, Houston

13273 Cedex 9

Institut Paoli Calmettes, Marseille

44202 Cedex 2

Hopital Prive du Confluent, Nantes BP 20215

67091Cedex

Hopitaux Universitaires de Strasbourg - Hopital Civil, Strasbourg

31059 Cedex 9

Institut Universitaire du Cancer Toulouse - Oncopole, Toulouse

01307

University Hospital Carl Gustav Carus, Dresden

08035

Hospital Universitari Vall d'Hebron, Barcelona

03550

Hospital Universitario San Juan de Alicante, Sant Joan d'Alacant

CB2 0QQ

Cambridge University Hospital NHS Foundation Trust, Cambridge

W1G 6AD

Sarah Cannon Research Institute UK, London

PR2 9HT

Lancashire Teaching Hospitals NHS Foundation Trust, Preston

SW3 6JJ

The Royal Marsden NHS Foundation Trust, London

M20 4BX

The Christie NHS Foundation Trust, Manchester

SM2 5PT

The Royal Marsden NHS Foundation Trust, Sutton

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Myriad Genetic Laboratories, Inc.

INDUSTRY

collaborator

Medivation, Inc.

INDUSTRY

lead

Pfizer

INDUSTRY