A Study Evaluating Safety and Efficacy of the Addition of ABT-888 Plus Carboplatin Versus the Addition of Carboplatin to Standard Chemotherapy Versus Standard Chemotherapy in Subjects With Early Stage Triple Negative Breast Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

634

Participants

Timeline

Start Date

April 2, 2014

Primary Completion Date

March 18, 2016

Study Completion Date

November 12, 2020

Conditions
Triple Negative Breast Cancer
Interventions
DRUG

Cyclophosphamide

Cyclophosphamide

DRUG

Placebo

Placebo for Carboplatin

DRUG

Doxorubicin

Doxorubicin

DRUG

Paclitaxel

Paclitaxel

DRUG

Carboplatin

Carboplatin

DRUG

Veliparib

Veliparib

DRUG

Placebo

Placebo for Veliparib

Trial Locations (158)

1020

CHU Brugmann /ID# 120376, Brussels

1122

National Institute of Oncology /ID# 120828, Budapest

1134

Magyar Honvedseg Egeszsegugyi Kozpont /ID# 120834, Budapest

1145

Uzsoki Utcai Korhaz /ID# 120825, Budapest

1200

Cliniques Universitaires Saint Luc /ID# 120719, Woluwe-Saint-Lambert

2485

The Tweed Hospital /ID# 120235, Tweed Heads

2650

UZ Antwerp /ID# 120720, Edegem

3021

Western Health Sunshine Hosp. /ID# 120715, St Albans

3050

Royal Melbourne Hospital /ID# 127717, Parkville

3144

Cabrini Health /ID# 120236, Malvern

3526

BAZ Megyei E.O. Korhaz /ID# 122215, Miskolc

4032

Debreceni Egyetem Klinikai Kozpont /ID# 116681, Debrecen

5000

CHU UCL Namur /ID# 116677, Namur

5004

Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz /ID# 120818, Szolnok

6000

Grand Hôpital de Charleroi /ID# 116678, Charleroi

Bacs-Kiskun Megyei Korhaz /ID# 120833, Kecskemét

6008

St. John of God Subiaco Hosp /ID# 120717, Subiaco

6150

Fiona Stanley Hospital /ID# 120716, Murdoch

St. John of God Hosp - Murdoch /ID# 131788, Murdoch

6720

University of Szeged /ID# 120823, Szeged

8500

AZ Groeninge /ID# 120718, Kortrijk

9023

Petz Aladar Megyei Oktato Korh /ID# 120835, Győr

10002

National Taiwan Univ Hosp /ID# 122895, Taipei City

10408

National Cancer Center /ID# 119525, Goyang

13125

Helios Klinikum Berlin Buch /ID# 133465, Berlin

15006

Hospital Universitario A Coruña - CHUAC /ID# 135108, A Coruña

16499

Ajou University Hospital /ID# 118856, Suwon

18103

Lehigh Valley Health Network /ID# 133372, Allentown

18840

Guthrie Medical Group, PC /ID# 124397, Sayre

19713

Christiana Care Health Service /ID# 137823, Newark

20141

Istituto Europeo di Oncologia /ID# 120845, Milan

21201

Univ Maryland School Medicine /ID# 119235, Baltimore

22908

University of Virginia /ID# 122975, Charlottesville

23219

Virginia Commonwealth Univ /ID# 141586, Richmond

23456

Virginia Oncology Associates /ID# 127260, Virginia Beach

24105

Universitaetsklinikum Schleswig-Holstein /ID# 133454, Kiel

25198

Hospital Universitario Arnau de Vilanova de Lleida /ID# 120979, Lleida

27100

IRCCS Fondazione Salva Maugeri /ID# 120848, Pavia

27103

Novant Health Oncology Special /ID# 139890, Winston-Salem

28034

Hospital Universitario Ramon y Cajal /ID# 135113, Madrid

28040

Hospital Clinico Universitario San Carlos /ID# 119959, Madrid

28205

Klinikum Bremen Mitte gGmbH /ID# 132875, Bremen

28816

Hope Womens Cancer Centers /ID# 119179, Asheville

31059

Hopital Universitaire Purpan /ID# 120731, Toulouse

32224

Mayo Clinic /ID# 132349, Jacksonville

32806

UF Health Cancer Center /ID# 141589, Orlando

33140

Mount Sinai Comp Cancer Ctr /ID# 133008, Miami

33176

Miami Cancer Institute - Baptist Health South Florida /ID# 126145, Miami

33604

Studiengesellschaft Onk Bielef /ID# 133471, Bielefeld

33916

Florida Cancer Specialists - Fort Myers /ID# 121835, Fort Myers

Florida Cancer Specialists - Fort Myers /ID# 126379, Fort Myers

34117

Elisabeth Krankenhaus /ID# 133461, Kassel

37203

Tennessee Oncology, PLLC /ID# 124566, Nashville

39576

Johanniter-Krankenhaus Genthin /ID# 133463, Stendal

40138

A.O.U. Policlinico S.Orsola-Malpighi /ID# 122855, Bologna

41013

Hospital Universitario Virgen del Rocio /ID# 135114, Seville

41404

Kyungpook National University Chilgok Hospital /ID# 118855, Daegu

43210

The Ohio State University /ID# 141587, Columbus

44106

University Hospitals Case Medical Center /ID# 141691, Cleveland

44111

Fairview Hospital /ID# 141626, Cleveland

44137

St. Johannes Hospital /ID# 133478, Dortmund

44195

Cleveland Clinic Main Campus /ID# 126378, Cleveland

45252

Oncology Hematology Care, Inc - Blue Ash /ID# 120478, Cincinnati

45879

Evangelisches Krankenhaus /ID# 133457, Gelsenkirchen

46009

Fundacion Instituto Valenciano Oncologia IVO /ID# 135116, Valencia

46010

Hospital Clinico Universitario de Valencia /ID# 123076, Valencia

46014

Hospital General Universitario de Valencia /ID# 135111, Valencia

46202

Indiana Univ School Medicine /ID# 118215, Indianapolis

46256

Community Rgnal Cancer Care N /ID# 120456, Indianapolis

47014

IRCCS-I.R.S.T. srl Meldola /ID# 120255, Meldola

47905

Horizon Oncology Research Center /ID# 116815, Lafayette

48106

St. Joseph Mercy Hospital /ID# 135875, Ypsilanti

50006

Changhua Christian Hospital /ID# 119085, Changhua County

50009

Hospital Universitario Miguel Servet /ID# 119195, Zaragoza

55404

Minnesota Oncology Hematology, PA /ID# 126144, Minneapolis

57105

Avera Cancer Institute /ID# 120466, Sioux Falls

58100

Misericordia General Hospital /ID# 119536, Grosseto

58102

Sanford Roger Maris Cancer Cen /ID# 132394, Fargo

58452

Marienhospital Witten /ID# 133470, Witten

59020

Centre Oscar Lambret /ID# 119958, Lille

60153

Loyola University Medical Ctr /ID# 120455, Maywood

60607

University of Illinois - Chicago /ID# 134329, Chicago

61108

OSF St. Anthony Medical Center /ID# 139424, Rockford

63011

Jean Perrin Centre /ID# 125277, Clermont-Ferrand

63069

Sana Klinikum Offenbach /ID# 133455, Offenbach

65189

St. Josefs-Hospital /ID# 133464, Wiesbaden

65549

St. Vincenz Krankenhaus /ID# 133466, Limburg

65929

Klinikum Frankfurt Hoechst /ID# 145301, Frankfurt

67214

Cancer Center of Kansas /ID# 134720, Wichita

69373

Centre Leon Berard /ID# 120740, Lyon

73657

Chi Mei Hospital - Liouying /ID# 120982, Tainan City

73730

Kliniken Esslingen /ID# 133475, Esslingen am Neckar

75015

Hosp European, Georges Pompid /ID# 120736, Paris

75075

Texas Oncology - Plano East /ID# 126143, Plano

75230

Texas Oncology - Medical City Dallas /ID# 126140, Dallas

Texas Oncology - Medical City Dallas /ID# 126141, Dallas

75248

Institut Curie /ID# 116679, Paris

75702

Texas Oncology - Tyler /ID# 126142, Tyler

76022

Texas Oncology - Bedford /ID# 126135, Bedford

76104

The Ctr for Cancer and Blood D /ID# 120479, Fort Worth

77024

Texas Oncology - Memorial City /ID# 126139, Houston

80634

Onk Zentrum am Rotkreuz /ID# 133482, Munich

80802

Klinikum recht der Isar der TU /ID# 133449, Munich

85259

Mayo Clinic - Scottsdale /ID# 139932, Scottsdale

86150

Gemeinschaftspraxis Dr. Heinrich und Prof. Bangerter /ID# 133472, Augsburg

89081

Universitaetsklinikum Ulm /ID# 133453, Ulm

89169

Comprehensive Cancer Ctrs Neva /ID# 126136, Las Vegas

90033

Usc /Id# 123310, Los Angeles

90048

Cedars-Sinai Medical Center - West Hollywood /ID# 137275, West Hollywood

90766

Wilke/Wagner/Petzoldt, Fuerth /ID# 133481, Fürth

92123

Sharp Memorial Hospital /ID# 119861, San Diego

92210

Hopital Rene Huguenin /ID# 120729, Saint-Cloud

93901

Pacific Cancer Care /ID# 120476, Salinas

97422

Leopoldina-Krankenhaus /ID# 133484, Schweinfurt

115478

Federal State Budgetary Scientific Institution N.N. Blokhin Russian Cancer Resea /ID# 120944, Moscow

163045

archangel Clinical Oncology /ID# 120935, Arkhangelsk

188663

Leningrad Reg Onc Dispensery /ID# 120938, Saint Petersburg

197183

Birch A Healthcare /ID# 116695, Saint Petersburg

249036

Medical Radiological Res Ctr /ID# 124017, Obninsk

305035

Kursk Regional Oncology Dispen /ID# 116688, Kursk

357502

Pyatigorsk Oncology Dispensary /ID# 120945, Pyatigorsk

85258-4566

Scottsdale Healthcare /ID# 120473, Scottsdale

85711-2701

Arizona Oncology Associates, PC-HOPE /ID# 126137, Tucson

94305-2200

Stanford University School of Med /ID# 130316, Stanford

33612-9416

Moffitt Cancer Center /ID# 124063, Tampa

60611-2927

Northwestern University Feinberg School of Medicine /ID# 133848, Chicago

60637-1443

University of Chicago DCAM /ID# 120467, Chicago

64111-5905

St. Lukes Cancer Institute /ID# 118775, Kansas City

03103

Solinksy Center for Cancer Care /ID# 131970, Manchester

08903

Rutgers Cancer Institute of NJ /ID# 120477, New Brunswick

10032-3725

Columbia Univ Medical Center /ID# 141588, New York

27514-4220

Univ NC Chapel Hill /ID# 132893, Chapel Hill

Univ NC Chapel Hill /ID# 147695, Chapel Hill

02905

Women and Infants Hospital /ID# 123476, Providence

75390-7208

UT Southwestern Medical Center /ID# 133849, Dallas

84112-5500

University of Utah /ID# 118677, Salt Lake City

53792-0001

Univ of Wisconsin Hosp/Clinics /ID# 120457, Madison

M4N 3M5

Sunnybrook Health Sciences Ctr /ID# 123312, Toronto

H2X 0A9

CHUM - Notre-Dame Hospital /ID# 141694, Montreal

H3T 1E2

Jewish General Hospital /ID# 141629, Montreal

G1S 4L8

CHUQ-Hospital St. Sacrement /ID# 141619, Québec

779 00

Fakultni Nemocnice Olomouc /ID# 120725, Olomouc

656 53

Masarykuv onkologikcy ustav /ID# 120726, Brno

500 05

FN Hradec Kralove /ID# 120596, Hradec Králové

1081 HV

Vrije Universiteit Medisch Centrum /ID# 126302, Amsterdam

03722

Severance Hospital /ID# 116699, Seoul

06351

Samsung Medical Center /ID# 119276, Seoul

02841

Korea University Anam Hospital /ID# 118857, Seoul

03080

Seoul National University Hospital /ID# 116698, Seoul

05505

Asan Medical Center /ID# 116696, Seoul

08916

Hospital Universitario Germans Trias i Pujol /ID# 135112, Badalona

03010

Hospital General Universitario Alicante /ID# 135115, Alicante

08003

Hospital Parc de Salut del Mar /ID# 135110, Barcelona

08041

Hospital Santa Creu i Sant Pau /ID# 145400, Barcelona

BS2 8EG

Univ Hosp Bristol NHS Foundati /ID# 120989, Bristol

W6 8RF

Charing Cross Hospital /ID# 120990, London

NG5 1PB

Nottingham Univ Hospitals NHS /ID# 122218, Nottingham

ST4 6QG

Royal Stoke Univ Hospital /ID# 120984, Stoke-on-Trent

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

GBG Forschungs GmbH

OTHER

collaborator

NSABP Foundation Inc

NETWORK

collaborator

Grupo Español de Investigación del Cáncer de Mama

UNKNOWN

collaborator

US Oncology Research

INDUSTRY

lead

AbbVie

INDUSTRY