Systemic Therapy and Chemoradiation in Advanced Localised Pancreatic Cancer - 2

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

159

Participants

Timeline

Start Date

March 31, 2016

Primary Completion Date

June 23, 2021

Study Completion Date

June 23, 2021

Conditions
Pancreatic Neoplasms (Locally Advanced Non-metastatic)
Interventions
DRUG

nab-paclitaxel

Abraxane is a proprietary solvent-free, protein-stabilized formulation of paclitaxel comprised of paclitaxel and human albumin in a noncrystalline amorphous state

RADIATION

60Gy in 30#

RADIATION

50.4Gy in 28#

DRUG

Nelfinavir

VIRACEPT® (nelfinavir mesylate) is an inhibitor of the human immunodeficiency virus (HIV) protease.

DRUG

Capecitabine

Given in combination with gemcitabine, known as GemCap.

DRUG

Gemcitabine

Gemcitabine is indicated for treatment of patients with locally advanced or metastatic adenocarcinoma of the pancreas. It is administered as an infusion

Trial Locations (23)

OX3 7LE

Oxford University Hospitals, Churchill Cancer Centre, Headington

AB25 2ZN

NHS Grampian, Aberdeen Royal Infirmary, Aberdeen

CH63 4JY

The Clatterbridge Cancer Centre NHS Foundation Trust, Bebington

BT9 7AB

Belfast Health and Social Care Trust, Belfast City Hospital, Belfast

BS2 8ED

University Hospitals Bristol NHS Foundation Trust, Bristol Haematology and Oncology Centre, Bristol

CB2 0QQ

Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge

CF14 2TL

Velindre NHS Trust, Velindre Cancer Centre, Cardiff

CO4 5JL

East Suffolk and North Essex NHS Foundation Trust, Colchester District General Hospital, Colchester

HU16 5JQ

Hull and East Yorkshire Hospitals NHS Trust, Castle Hill Hospital, Cottingham

CV2 2DX

University Hospitals Coventry and Warwickshire NHS Trust, University Hospital Coventry, Coventry

GU2 7XX

Royal Surrey County Hospital, Guildford

LS9 7TF

Leeds Teaching Hospitals NHS Trust, St James's University Hospital, Leeds

LN2 5QY

United Lincolnshire Hospitals NHS Trust, Lincoln County Hospital, Lincoln

N18 1QX

North Middlesex University Hospital NHS Trust, North Middlesex Hospital, London

NW1 2PG

University College London Hospitals NHS Foundation Trust, University College London Hospital, London

NW3 2QG

Royal Free Hampstead NHS Trust, Royal Free Hospital, London

W12 0HS

Hammersmith Hospital, London

M20 4BX

The Christie NHS Foundation Trust, The Christie Hospital, Manchester

MK6 5LD

Milton Keynes University Hospital, Milton Keynes

NR4 7UY

Norfolk and Norwich University Hospital, Norwich

NG5 1PB

Nottingham University Hospitals NHS Trust, City Hospital, Nottingham

PL6 8DH

Plymouth Hospitals NHS Trust, Derriford Hospital, Plymouth

S10 2SJ

Sheffield Teaching Hospitals, Weston Park Hospital, Sheffield

Sponsors

Collaborators (2)

All Listed Sponsors
collaborator

Celgene

INDUSTRY

collaborator

Cancer Research UK

OTHER

lead

University of Oxford

OTHER