The Amputation Surgical Site Infection Trial (ASSIT)

Augmentin 1.2g IV three times daily for 24 hours. If the patient is randomised to the 5-day duration antibiotic arm then Augmentin 625mg oral tablets three times daily are added to the 24 hour course for a further 4 days.

Intra-operative skin preparation prior to incision to skin.

500mg IV three times daily for 24 hours. If the patient is randomised to 5-day duration arm, then another 4 days of oral metronidazole at 400mg three times daily is added to the course

Alcoholic Chlorhexidine skin pre-op preparation

Teicoplanin 400mg on induction. If penicillin allergic and on 5-day antibiotic arm then add clindamycin 300mg 4 times daily for further 4 days

Clindamycin 300mg 4 times daily orally to be used in case of penicillin allergy