NCT02015117View on ClinicalTrials.gov

Trametinib With or Without Whole Brain Radiation Therapy in Treating Patients With Brain Metastases

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

April 28, 2014

Primary Completion Date

July 10, 2020

Study Completion Date

October 8, 2026

Conditions
Metastatic Malignant Neoplasm in the Brain
Interventions
OTHER

Laboratory Biomarker Analysis

Correlative studies

OTHER

Pharmacological Study

Correlative studies

PROCEDURE

Therapeutic Conventional Surgery

Undergo surgical resection of the tumor

DRUG

Trametinib

Given PO

RADIATION

Whole-Brain Radiotherapy

Undergo whole-brain radiation therapy

Trial Locations (1)

43210

Ohio State University Comprehensive Cancer Center, Columbus

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH