389
Participants
Start Date
March 17, 2014
Primary Completion Date
May 8, 2017
Study Completion Date
August 3, 2022
Bendamustine
Bendamustine will be administered at a dose of 70 mg/m\^2 via IV infusion on Days 1 and 2 of each 28-day cycle, for 6 cycles.
Venetoclax
"Venetoclax will be administered at an initial dose of 20 mg via tablet orally QD, incremented weekly up to a maximum dose of 400 mg during a 5-week ramp-up period. Venetoclax will be continued at 400 mg QD from Week 6 (Day 1 of Cycle 1 of combination therapy) onwards up to disease progression (PD) or 2 years, whichever occurs first.~R/C Substudy: venetoclax will be administered for 5-week dose ramp-up period to reach the target dose of 400 mg QD. Venetoclax will continue to be administered during the rituximab cycles until disease progression or for a maximum of 2 years from Cycle 1R/C Day 1 of the R/C Substudy."
Rituximab
"Rituximab will be administered at a dose of 375 mg/m\^2 via IV infusion on Day 1 of Cycle 1 and at a dose of 500 mg/m\^2 on Day 1 of Cycles 2-6.~R/C Substudy: Following the venetoclax ramp-up period, rituximab will be administered for 6 cycles consisting of a single infusion on the first day of each 28-day cycle."
Baxter Healthcare, Mount Wellington
Semmelweis Egyetem, Budapest
Medizinische Universität Wien, Vienna
Orszagos Onkologiai Intezet, Budapest
Klinik Ottakring, Vienna
Cliniques Universitaires Saint-Luc; Hematology, Brussels
North Shore Hospital; Haematolgy, Auckland
ZNA Antwerpen; Department Hematology, Antwerp
The Canberra Hospital, Garran
Rigshospitalet, København Ø
Concord Repatriation General Hospital, Concord
St George Hospital, Kogarah, New South Wales
Herlev Hospital, Herlev
UZ Leuven; Department Hematology, Leuven
Royal Melbourne Hospital, Parkville
Peter MacCallum Cancer Center, North Melbourne
Slade Health Pharmacy, Mount Waverley
Monash Medical Centre; Haematology, Melbourne
Frankston Hospital, Frankston
UMC Utrecht, Utrecht
Sjællands Universitetshospital, Roskilde, Roskilde
Debreceni Egyetem Klinikai Központ; B?rgyógyászati Klinika, Debrecen
Princess Alexandra Hospital, Woolloongabba
Royal Adelaide Hospital, Adelaide
Odense Universitetshospital, Odense C
LKH - Universitätsklinikum der PMU Salzburg, Salzburg
Flinders Medical Centre, Bedford Park
CHU UCL Mont-Godinne, Mont-godinne
The Perth Blood Institute, Nedlands
Medizinische Universität Innsbruck, Innsbruck
The Catholic University of Korea Seoul St. Mary?s Hospital, Seoul
Szegedi Tud.Egyetem Szent-Gyorgyi Albert Klin.Kozp., Szeged
Royal Hobart Hospital, Hobart
Sygehus Lillebælt, Vejle, Vejle
Somogy Megyei Kaposi Mor Oktato Korhaz, Pécs
Christchurch Hospital NZ, Christchurch
AZ Groeninge, Kortrijk
AZ Delta (Campus Rumbeke), Roeselare
National Taiwan University Hospital, Taipei
Memorial Sloan Kettering Cancer Center; Clinical Trials Office, New York
Perlmutter Cancer Center NYU Langone Health, New York
Azienda Ospedaliera Città della Salute e della Scienza di Torino; Radiology, Torino
Azienda Ospedaliero Universitaria San Martino, Genoa
Ospedale San Raffaele, Milan
Asst Grande Ospedale Metropolitano Niguarda; SC Farmacia Ospedale, Milan
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni XXIII), Bergamo
Hospital Universitario 12 de Octubre, Madrid
Hôpital Morvan, Brest
Complejo Hospitalario de Navarra, Pamplona
Institut Universitaire du Cancer - Oncopole Toulouse (IUCT-O), Toulouse
Hopital Saint Eloi, Montpellier
CHU de Rennes - Hopital de Pontchaillo, Rennes
Azienda Ospedaliera Di Padova, Padua
Hospital Clinico Universitario de Salamanca, Salamanca
CHU Tours - Hôpital Bretonneau, Tours
CHU Nantes - Hôtel Dieu; Service Assistance Medicale à la Procreation, Nantes
Samodzielny Publiczny Szpital Kliniczny nr 1, Zabrze
Henry Ford Health System, Detroit
Azienda Ospedaliera Universitaria Careggi, Florence
Hôpital de Brabois Adultes, Vandœuvre-lès-Nancy
Hopital Claude Huriez - CHU Lille, Lille
Azienda Ospedaliero Universitaria Ospedali Riuniti, Torrette Di Ancona
Centre Hospitalier Lyon Sud, Pierre-Bénite
Istituto Tumori Giovanni Paolo II IRCCS Ospedale Oncologico Bari, Bari
Universitätsklinikum Tübingen, Tübingen
Hopital Robert Debre, Paris
Centre Henri Becquerel, Rouen
Universitaetsklinikum Freiburg, Freiburg im Breisgau
Huntsman Cancer Institute; University of Utah, Salt Lake City
Centre Hospitalier Départemental Les Oudairies, La Roche-sur-Yon
CHU Poitiers - Hopital La Miletrie, Poitiers
"FSBSI Russian Oncological Scientific Center n.a. N.N. Blokhin", Moscow
SRI of Hematology and Transfusiology, Saint Petersburg
North-West Federal Medical Research Center n.a. V.A. Almazov, Saint Petersburg
BHI of Omsk region Clinical Oncology Dispensary, Omsk
Kemerovo Regional Clinical Hospital, Kemerovo
University of California San Diego Medical Center, La Jolla
Foothills Medical Centre; Centre Dept of Medical Clinical Neuroscience, Calgary
Juravinski Cancer Clinic, Hamilton
Jewish General Hospital, Montreal
Saskatoon City Hospital;Saskatchewan Cancer Centre, Saskatoon
Fakultni nemocnice Brno, Brno
Fakultni nemocnice Hradec Kralove, Hradec Králové
Fakultní nemocnice Olomouc, Olomouc
Fakultni nemocnice Ostrava, Ostrava - Poruba
Fakultni nemocnice Kralovske Vinohrady, Prague
Vseobecna fakultni nemocnice v Praze, Prague
"Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden", Dresden
Amsterdam UMC, Locatie VUMC; Neurology, Amsterdam
Amsterdam UMC Location AMC, Amsterdam
Albert Schweitzer Ziekenhuis, Dordwijk; Internal Medicine, Hemato-Oncology, Dordrecht
Medisch Spectrum Twente, Enschede
Leids Universitair Medisch Centrum; Cardiology, Leiden
Erasmus Medisch Centrum, Rotterdam
Middlemore Hospital, Auckland
Uniwersyteckie Centrum Kliniczne, Gdansk
SP ZOZ Zespol Szpitali Miejskich w Chorzowie, Chorzów
Wojewódzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika w Lodzi, Lodz
Szpital Wojewodzki w Opolu, Opole
MTZ Clinical Research Sp. z o.o., Warsaw
Seoul National University Bundang Hospital, Seongnam-si
Severance Hospital, Yonsei University Health System, Seoul
Konkuk University Medical Center, Seoul
Hospital Universitari Vall d'Hebron, Barcelona
Hospital Clinic i Provincial de Barcelona; Hematology, Barcelona
Skånes Universitetssjukhus, Lund
Akademiska Sjukhuset, Uppsala
Bristol Haematology and Oncology centre, Bristol
The Christie, Manchester
Southampton General Hospital, Southampton
Singleton Hospital; Pharmacy Department, Swansea
Collaborators (1)
AbbVie
INDUSTRY
Hoffmann-La Roche
INDUSTRY