Comparing Photon Therapy To Proton Therapy To Treat Patients With Lung Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

330

Participants

Timeline

Start Date

February 3, 2014

Primary Completion Date

December 1, 2027

Study Completion Date

October 31, 2028

Conditions
Stage II Non-Small Cell Lung Cancer AJCC v7Stage IIA Non-Small Cell Lung Carcinoma AJCC v7Stage IIB Non-Small Cell Lung Carcinoma AJCC v7Stage III Non-Small Cell Lung Cancer AJCC v7Stage IIIA Non-Small Cell Lung Cancer AJCC v7Stage IIIB Non-Small Cell Lung Cancer AJCC v7
Interventions
DRUG

Carboplatin

Given IV

DRUG

Cisplatin

Given IV

BIOLOGICAL

Durvalumab

Given IV

DRUG

Etoposide

Given IV

DRUG

Paclitaxel

Given IV

DRUG

Pemetrexed Disodium

Given IV

RADIATION

Photon Beam Radiation Therapy

Undergo photon beam radiation therapy

RADIATION

Proton Beam Radiation Therapy

Undergo proton beam radiation therapy

OTHER

Quality-of-Life Assessment

Ancillary studies

OTHER

Questionnaire Administration

Ancillary studies

Trial Locations (30)

10065

Memorial Sloan Kettering Cancer Center, New York

10591

Memorial Sloan Kettering Sleepy Hollow, Sleepy Hollow

10604

Memorial Sloan Kettering Westchester, Harrison

11570

Memorial Sloan Kettering Rockville Centre, Rockville Centre

11725

Memorial Sloan Kettering Commack, Commack

19104

University of Pennsylvania/Abramson Cancer Center, Philadelphia

19107

Thomas Jefferson University Hospital, Philadelphia

21014

Upper Chesapeake Medical Center, Bel Air

21044

Central Maryland Radiation Oncology in Howard County, Columbia

21061

Tate Cancer Center, Glen Burnie

21201

Maryland Proton Treatment Center, Baltimore

University of Maryland/Greenebaum Cancer Center, Baltimore

32209

University of Florida Health Science Center - Jacksonville, Jacksonville

37909

Tennessee Cancer Specialists-Dowell Springs, Knoxville

45069

West Chester Hospital, West Chester

45267

University of Cincinnati Medical Center, Cincinnati

60555

Northwestern Medicine Cancer Center Warrenville, Warrenville

63110

Washington University School of Medicine, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

77030

M D Anderson Cancer Center, Houston

77058

MD Anderson Regional Care Center-Bay Area, Nassau Bay

77094

MD Anderson Regional Care Center-Katy, Houston

77384

MD Anderson Regional Care Center-The Woodlands, The Woodlands

77478

MD Anderson Regional Care Center-Sugar Land, Sugar Land

98133

ProCure Proton Therapy Center-Seattle, Seattle

98195

University of Washington Medical Center, Seattle

02114

Massachusetts General Hospital Cancer Center, Boston

01923

Mass General/North Shore Cancer Center, Danvers

07920

Memorial Sloan Kettering Basking Ridge, Basking Ridge

08873

ProCure Proton Therapy Center-Somerset, Somerset

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

NRG Oncology

OTHER

lead

Radiation Therapy Oncology Group

NETWORK

NCT01993810 - Comparing Photon Therapy To Proton Therapy To Treat Patients With Lung Cancer | Biotech Hunter | Biotech Hunter