The Role of the Tumor Microenvironment of Pancreatic Cancer to Predict Treatment Outcome

0.1 ml/kg Gadovist is administered at 5 ml/s followed by a 15 ml saline flush

400 MBq \[F-18\]HX4, is administered in a single intravenous bolus injection, followed by a saline flush.

1000 mg/m2/dose on day 1 and 8 in 2 cycles of 21 days (three weeks) each, one cycle before and one cycle after radiochemotherapy. During radiotherapy gemcitabine is administered at 1000 mg/m2/dose on day 1, 8 and 15.

A hypofractionated scheme of 15 fractions of 2.4 Gy in three weeks will be applied, combined with the second course of gemcitabine.