Efficacy and Safety of Idelalisib in Combination With Bendamustine and Rituximab in Adults With Previously Untreated Chronic Lymphocytic Leukemia

PHASE3TerminatedINTERVENTIONAL
Enrollment

311

Participants

Timeline

Start Date

February 5, 2014

Primary Completion Date

May 30, 2016

Study Completion Date

June 16, 2016

Conditions
Chronic Lymphocytic Leukemia
Interventions
DRUG

Idelalisib

150 mg tablet administered orally twice daily

DRUG

Bendamustine

Administered intravenously at a starting dose of 90 mg/m\^2 for up to 6 cycles. Dosing will be based on mg/m\^2 of body surface area.

DRUG

Rituximab

Single-use vials administered intravenously weekly starting at 375 mg/m\^2 on Day 1 (Week 0) and 500 mg/m\^2 thereafter for a total of 6 infusions

DRUG

Placebo

Placebo to match idelalisib administered orally twice daily

Trial Locations (91)

1083

Semmelweis University, Budapest

1122

National Institute of Oncology, Budapest

2010

St Vincent's Hospital, Sydney, Darlinghurst

2060

Z N A Stuivenberg, Antwerp

2250

Jarrett Street Specialist Centre, North Gosford

2298

Calvary Mater Newcastle, Waratah

2800

Szent Borbála Hospital, Tatabánya

3000

University Hospital Leuven, Leuven

3199

Frankston Hospital, Frankston

3220

Barwon Health, University Hospital Geelong, Geelong

4032

University of Debrecen HSC Institute of internal Medicine, Department of Hematology, Debrecen

5000

Haematology and Bone Marrow Transplant Unit, Royal Adelaide Hospital, Adelaide

5011

Queen Elizabeth Hospital, Woodville South

5037

Ashford Cancer Centre Research, Kurralta Park

5042

Flinders Medical Centre, Department of Haematology, Level 6, Bedford Park

5700

Pandy Kalman Hospital, Gyula

6725

Szegedi Tudomanyegyetem AOK - Szent-Gyorgyi Albert Klinikai Kozpont, II. Belgyógyászati Klinika, Szeged

7400

Kaposi Mor Oktato Korhaz, Intezeti Gyogyszertar,, Kaposvár

7624

University Of Pecs, Medical School, Pécs

8000

AZ Sint-Jan AV Brugge-Oostende, Bruges

8041

Hospital de la Santa Creu i Sant Pau, Barcelona

8908

ICO, Hospitalet de Llobregat, Barcelona

10000

Klinicka bolnica Dubrava, Zagreb

Klinicka bolnica Merkur, Zagreb

UHC Zagreb, Zagreb

10032

Columbia University Medical Center, New York

10034

Faculty Hospital Kralovske Vinohrady, Prague

14642

University of Rochester, Rochester

20007

Georgetown University, Washington D.C.

20125

Spitalul Clinic Colentina, Bucharest

20132

Ospedale San Raffaele, Milan

20817

Center for Cancer and Blood Disorders, Bethesda

28006

Hospital Universitario La Princesa, Madrid

28007

Hospital Gregorio Marañon, Madrid

28033

Hospital Universitario Ramón Y Cajal, Madrid

28041

Hospital 12 de Octubre, Madrid

28100

AOU Maggiore della Carità, Novara

28222

Hospital Universitario Puerta De Hierro, Madrid

29601

Saint Francis Hospital, Greenville

32256

Cancer Specialists of North Florida, Jacksonville

33021

Memorial Healthcare System, Hollywood

34236

Florida Cancer Specialists-South, Sarasota

37044

CHU Bretonneau, Tours

37203

Sarah Cannon Research Institute, Nashville

41124

Azienda Ospedaliero Universitaria Policlinico di Modena, Modena

44718

Gabrail Cancer Center Research, Canton

45042

Signal Point Clinical Research Center, Middletown

45242

Sarah Cannon Research Institute, Cincinnati

46237

Franciscan Physician Network Oncology & Hematology, Indianapolis

51101

Siouxland Hematology-Oncology Associates, LLP, Sioux City

59037

CHRU de Lille, Hopital Claude Huriez, Lille

62500

University Hospital, Brno

70024

IRCCS Istituto Tumori, Bari

70852

Faculty hospital Ostrava, Ostrava-Poruba

75010

Hospital Saint-Louis, Paris

75246

Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas

78705

Texas Oncology-Austin Midtown, Austin

84103

Utah Cancer Specialists, Salt Lake City

89074

Comprehensive Cancer Centers of Nevada, Las Vegas

92093

UCSD Moores Cancer Center, La Jolla

92835

St. Jude Heritage Healthcare Virginia K. Crosson Cancer Center, Fullerton

93454

Central Coast Medical Oncology, Santa Maria

98109

Fred Hutchinson Cancer Research Center, Seattle

500326

Emergency County Clinical Hospital Brasov, Brasov

07962

Hematology /Oncology Associates of Northern New Jersey, Morristown

R3E 0V9

Cancercare Manitoba - Maccharles Unit, Winnipeg

M4N 3M5

Sunnybrook Health Sciences Centre, Toronto

M5G 2C9

Princess Margaret Cancer Centre, Toronto

H4J 1C5

Hôpital du Sacré-Coeur de Montréal, Montreal

G1J 1Z4

CHU de Québec - Hôpital de l'Enfant-Jésus, Québec

500 05

Faculty Hospital Hradec Kralove, Hradec Králové

304 60

Faculty Hospital Plzen, Pilsen

09121

Ospedale Oncologico Armando Businco, Cagliari

80-952

Uniwersyteckie Centrum Kliniczne, Gdansk

30-510

Malopolskie Centrum Medyczne s.c., Krakow

93-510

Wojewodzki Szpital Specjalistyczny im. M. Kopernika Klinika Hematologii, Lodz

02-507

Centralny Szpital Kliniczny MSW w Warszawie Klinika Onkologii i Hematologii, Warsaw

02-781

Centrum Onkologii-Instytut Marii Sklodowskiej -Curie klinika Nowotworow Ukladu Chlonnego, Warsaw

50-367

Samodzielny Publiczny Szpital Kliniczny nr 1 we Wroclawiu Klinika i Katedra Hematologii,Nowotworow Krwi i Transplantacji Szpiku, Wroclaw

53-439

Dolnoslakie Centrum Transplantacji Komorkowych z Krajowym Bankiem Dawcow Szpiku, Wroclaw

08035

Hospital Vall de Hebron, Barcelona

08036

Hospital Clinic, Barcelona

WC1E 6BT

University College London, London

CT1 3NG

East Kent Hospitals University NHS Foundation Trust, Canterbury

SM2 5PT

Royal Marsden NHS Trust, Sutton

CF14 4XW

University Hospital of Wales, Cardiff

L7 8XP

Royal Liverpool & Broadgreen Univ. Hospitals NHS Trust, Liverpool

W12 0HS

Hammersmith Hospitals NHS Trust, London

OX37LE

Oxford University Hospitals, Oxford

SO16 6YD

University Hospital Southampton NHS Trust, Southampton

WV10 0QP

Royal Wolverhampton Hospital NHS Trust, New Cross Hospital, Wolverhampton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Gilead Sciences

INDUSTRY

NCT01980888 - Efficacy and Safety of Idelalisib in Combination With Bendamustine and Rituximab in Adults With Previously Untreated Chronic Lymphocytic Leukemia | Biotech Hunter | Biotech Hunter