A Study of Participant Satisfaction and Safety With Subcutaneously Administered Trastuzumab (Herceptin) in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Early Breast Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

174

Participants

Timeline

Start Date

February 21, 2014

Primary Completion Date

December 22, 2016

Study Completion Date

November 25, 2018

Conditions
Breast Cancer
Interventions
DRUG

Trastuzumab

Trastuzumab will be administered subcutaneously at a fixed dose of 600 mg (irrespective of body weight) every 3 weeks for 1 year (adjuvant or neo-adjuvant plus adjuvant therapy).

DRUG

Doxorubicin

Doxorubicin will be administered in combination with trastuzumab and cyclophosphamide in the adjuvant setting as per local Product Information and the investigator's discretion.

DRUG

Cyclophosphamide

Cyclophosphamide will be administered in combination with trastuzumab and doxorubicin in the adjuvant setting as per local Product Information and the investigator's discretion.

DRUG

Paclitaxel

Paclitaxel will be administered in combination with trastuzumab in the adjuvant setting as per local Product Information and the investigator's discretion.

DRUG

Docetaxel

Docetaxel will be administered in combination with trastuzumab in the adjuvant setting as per local Product Information and the investigator's discretion.

DRUG

Carboplatin

Carboplatin will be administered in combination with trastuzumab and docetaxel in the adjuvant setting as per local Product Information and the investigator's discretion.

DRUG

Neo-adjuvant chemotherapy

Neo-adjuvant chemotherapy will be administered according to local guidelines in combination with trastuzumab in the neo-adjuvant setting. The study protocol does not mention any specific neo-adjuvant chemotherapy drug names.

Trial Locations (23)

1029

Institut Salah Azaïz; Service de Médecine Carcinologique, Tunis

2080

Abderrahmen Mami Hospital; Medical Oncology department, Aryanah

3029

Habib Bourguiba Hospital; Oncology department, Sfax

4031

Farhat Hached Hospital; Oncology department, Sousse

6213

Institut National D'oncologie Sidi Med Benabdellah, Rabat

11472

King Khaled Uni Hospital; Oncology, Riyadh

16016

Centre hospitalo-univerisitaire de Rouiba;Service d'oncologie médicale, Algiers

16340

Centre Anti Cancer Beau-fraisier;Service d'oncologie médicale, Algiers

20052

Clinique Littoral, Casablanca

21280

Dicle University Faculty of Medicine, Diyarbakır

21451

International Medical Center (IMC), Jeddah

22030

Trakya University Medical Faculty, Edirne

23000

CHU Annaba; Service d'Oncologie Médicale, Annaba

27310

Gaziantep Univ. Med. Fac., Gaziantep

31000

EHS Oncologie Emir Abdelkader Oran; Service d'Oncologie Médicale, Oran

34098

İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Istanbul

34286

Bezmialem Vakif Univ Medical, Istanbul

34890

Marmara Uni Faculty of Medicine; Medical Oncology, Istanbul

35100

Ege University Medical Faculty, Izmir

40000

Centre Hospitalier Universitaire Mohamed VI; Oncologie-Hématologie, Marrakesh

06500

Gazi University Medical Faculty; Department of İnternal Medicine, Ankara

07058

Akdeniz Univesity Medical Faculty, Antalya

06100

Hacettepe Uni Medical Faculty Hospital; Oncology Dept, Sıhhiye, Ankara

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT01964391 - A Study of Participant Satisfaction and Safety With Subcutaneously Administered Trastuzumab (Herceptin) in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Early Breast Cancer | Biotech Hunter | Biotech Hunter