Metformin's Effect on Glucagon-induced Glucose Production and Protein Metabolism.

PHASE1CompletedINTERVENTIONAL

Enrollment

Participants

Timeline

Start Date

October 31, 2013

Primary Completion Date

March 31, 2016

Study Completion Date

March 31, 2016

Conditions

Insulin ResistancePrediabetic State

Interventions

DRUG

Metformin

Metformin 1000mg daily for one week, then 2000 mg daily for the second week. 4 week washout period, then crossover to placebo.

DRUG

Placebo

Placebo tablets for 2 weeks, then 4 weeks of washout period, then crossover to metformin.

Trial Locations (1)

Mayo Clinic in Rochester, Rochester