Palbociclib (PD-0332991) Combined With Fulvestrant In Hormone Receptor+ HER2-Negative Metastatic Breast Cancer After Endocrine Failure (PALOMA-3)

PHASE3CompletedINTERVENTIONAL
Enrollment

521

Participants

Timeline

Start Date

September 26, 2013

Primary Completion Date

December 5, 2014

Study Completion Date

September 28, 2022

Conditions
Metastatic Breast Cancer
Interventions
DRUG

Palbociclib

Palbociclib 125 mg/day orally continuously dosed for 3 weeks followed by 1 week off; repeated at each subsequent cycle.

DRUG

Fulvestrant

Fulvestrant 500 mg intramuscularly on Days 1 and 15 of Cycle 1, and then on Day 1 of each subsequent 28 day cycle.

DRUG

Placebo

Placebo orally continuously dosed for 3 weeks followed by 1 week off; repeated at each subsequent cycle.

DRUG

Fulvestrant

Fulvestrant 500 mg intramuscularly on Days 1 and 15 of Cycle 1, and then on Day 1 of each subsequent 28 day cycle.

Trial Locations (247)

100

National Taiwan University Hospital, Taipei

704

National Cheng Kung University Hospital, Tainan City

1000

Institut Jules Bordet, Brussels

1070

Hopital Erasme, Brussels

1200

Cliniques Universitaires Saint-Luc, Brussels

1340

Clinique Saint-Pierre, Ottignies

2200

Bankstown - Lidcombe Hospital, Bankstown

2298

Calvary Mater Newcastle, Waratah

2610

GZA Ziekenhuizen - Campus St Augustinus, Wilrijk

2650

UZ Antwerpen, Edegem

2820

Imelda Ziekenhuis, Bonheiden

3000

Peter MacCallum Cancer Centre Pharmacy, Melbourne

Peter MacCallum Cancer Centre, Melbourne

UZ Leuven - Campus Gasthuisberg, Leuven

3021

Sunshine Hospital Clinical Trials Pharmacy, St Albans

Sunshine Hospital, St Albans

3144

Cabrini Hospital, Malvern

3168

Monash Medical Centre, Clayton

3186

Cabrini Brighton, Brighton

3199

Peninsula and Southeast Oncology, Frankston

3220

Barwon Health, University Hospital Geelong, Geelong

4066

River City Pharmacy, Auchenflower

4215

Icon Cancer Care Southport, Southport

4560

Sunshine Coast Hospital and Health Service, Nambour

5000

CHU UCL Namur - Site Sainte-Elisabeth, Namur

6000

Grand Hôpital de Charleroi - Site Notre Dame, Charleroi

6150

Fiona Stanley Hospital - Cancer Centre, Murdoch

6800

C.H. de l'Ardenne - site Libramont, Libramont-Chevigny

7100

INDC Entité Jolimontoise - CH de Jolimont-Lobbes, Haine-Saint-Paul

7500

CHWaPi - Site IMC, Tournai

10408

National Cancer Center, Goyang-si

10509

CareMount Medical, Brewster

10549

CareMount Medical, Mount Kisco

Northern Westchester Hospital, Mount Kisco

11042

ProHEALTHCARE Associates, LLP, Lake Success

15146

UPMC Cancer Center, Monroeville, Monroeville

15213

Magee Womens Hospital of UPMC, Pittsburgh

15232

University of Pittsburgh Medical Center, William M. Cooper Pavilion, Hillman Cancer Center, Pittsburgh

19104

Hospital of the University of Pennsylvania, Philadelphia

19107

Thomas Jefferson University, Philadelphia

20132

Farmacia IRCCS Ospedale San Raffaele, Milan

IRCCS Ospedale S. Raffaele, Milan

20133

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

20141

Istituto Europeo di Oncologia, Milan

Servizio di Farmacia - Istituto Europeo di Oncologia, Milan

20176

Virginia Cancer Specialists, PC, Leesburg

21029

Podilskyi rehionalnyi tsentr onkolohii,, Vinnytsia

21093

Sidney Kimmel Comprehensive Cancer Center (SKCCC) at Johns Hopkins, Green Spring Station, Lutherville

21231

Sidney Kimmel Comprehensive Cancer Center (SKCCC) at Johns Hopkins, Baltimore

22031

Inova Medical Group, Fairfax

Inova Schar Cancer Institute, Fairfax

Virginia Cancer Specialists, PC, Fairfax

22205

Virginia Cancer Specialists, PC, Arlington

22601

Shenandoah Oncology, P.C., Winchester

22903

Emily Couric Clinical Cancer Center, Charlottesville

23456

Virginia Oncology Associates, Virginia Beach

23502

Virginia Oncology Associates, Norfolk

28806

Hope Women's Cancer Centers, Asheville

Mission Hospital, Inc., Asheville

30060

Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital, Marietta

Northwest Georgia Oncology Centers, PC, Marietta

30106

Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital, Austell

30121

Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital, Cartersville

30214

Piedmont Cancer Institute, PC, Fayetteville

30318

Piedmont Cancer Institute, PC, Atlanta

32806

Orlando Health Cancer Institute, Orlando

33021

Memorial Breast Cancer Center at Memorial Regional Hospital, Hollywood

Memorial Cancer Institute at Memorial Regional Hospital, Hollywood

Memorial Regional Hospital, Hollywood

33028

Memorial Breast Cancer Center at Memorial Hospital West, Pembroke Pines

Memorial Cancer Institute at Memorial Hospital West, Pembroke Pines

Memorial Hospital West, Pembroke Pines

33136

University of Miami Hospitals & Clinics, Miami

33140

Mount Sinai Comprehensive Cancer Center, Miami Beach

Mount Sinai Medical Center, Miami Beach

33180

Mount Sinai Medical Center- Aventura, Aventura

33308

Holy Cross Hospital/Michael and Dianne Bienes Comprehensive Cancer Center, Fort Lauderdale

33324

Sylvester at Plantation, Plantation

33442

Sylvester Comprehensive Cancer Center Deerfield Beach, Deerfield Beach

University of Miami Hospitals and Clinics (UHMC) Sylvester at Deerfield Beach, Deerfield Beach

34761

Orlando Health, Ocoee

35040

Ege University Medical Faculty, Izmir

35233

University of Alabama at Birmingham, The Kirklin Clinic, Birmingham

35249

UAB Hospital-Investigational Drug Service, Birmingham

University of Alabama at Birmingham, Birmingham

36526

Southern Cancer Center, PC, Daphne

36607

Southern Cancer Center, PC, Mobile

36608

Southern Cancer Center, PC, Mobile

Southern Cancer Center,PC, Mobile

37045

Azienda U.L.S.S. n. 21 di Legnago, Presidio Ospedaliero Mater Salutis, Legnago (VR)

Farmacia Ospedaliera-Azienda U.L.S.S. n. 21 di Legnago, Legnago (VR)

38138

The Jones Clinic, PC, Germantown

40138

SSD Oncologia Medica Addarii-Zamagni A.O.U. di Bologna Policlinico S. Orsola Malpighi, Bologna

41124

Policlinico di Modena Dipartimento ad attivita integrata di Oncologia,, Modena

47014

IRST, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola (FC)

48109

University of Michigan Health System/Comprehensive Cancer Center, Ann Arbor

49102

Komunalnyi zaklad 'Miska klinichna likarnia No.4' Dniprovskoi miskoi rady,, Dnipro

49503

Cancer and Hematology Centers of Western Michigan, Grand Rapids

50012

Azienda Sanitaria Firenze, c/o Ospedale S. M. Annunziata Farmacia Interna, Bagno A Ripoli (FI)

S.O.C. Oncologia Medica I, Azienda Sanitaria Firenze, c/o Ospedale S. M. Annunziata, Bagno A Ripoli (FI)

53097

Columbia St. Mary's, Mequon

53211

Columbia St. Mary's, Milwaukee

55435

Fairview Southdale Oncology Clinic, Edina

55455

University of Minnesota Medical Center, Fairview, Minneapolis

University of Minnesota Physicians, Masonic Cancer Center, Minneapolis

58013

"Oblasne komunalne nekomertsiine pidpryiemstvo Bukovynskyi klinichnyi onkolohichnyi tsentr", Chernivtsi

60099

Cancer Treatment Centers of America at Midwestern Regional Medical Center, Zion

60612

Rush University Medical Center, Chicago

61070

"Komunalne nekomertsiyne pidpryiemstvo Oblasnyi", Kharkiv

63011

Mercy Clinic St. Louis Cancer and Breast Institute, Ballwin

63017

Mercy Ministry Office, Chesterfield

63109

Mercy Clinic St. Louis Cancer and Breast Institute, St Louis

63141

Mercy Hospital St. Louis, St Louis

Mercy Hospital St.Louis- David C. Pratt Cancer Center, St Louis

65025

"Komunalna ustanova Odeska oblasna klinichna likarnia", Odesa

75063

US Oncology Investigational Products Center (IPC), Irving

US Oncology lnvestigational Products Center (IPC), Irving

75231

Texas Oncology- Dallas Presbyterian Hospital, Dallas

75601

Texas Oncology- Longview Cancer Center, Longview

75702

Texas Oncology- Tyler, Tyler

76177

Investigational Products Center (IPC), Fort Worth

78212

Cancer Care Centers of South Texas, San Antonio

78217

Cancer Care Centers of South Texas, San Antonio

78258

Cancer Care Centers of South Texas, San Antonio

78503

Texas Oncology- McAllen South Second Street, McAllen

78596

Texas Oncology- Weslaco, Weslaco

79031

KNP Lvivskoi oblasnoi rady Lvivskyi onkolohichnyi, Lviv

80045

ATTN - Research Pharmacist, Aurora

University of Colorado Hospital - Anschutz Cancer Pavilion (ACP), Aurora

University of Colorado Hospital - Anschutz Outpatient Pavilion (AOP), Aurora

80131

IRCCS Istituto Nazionale per lo Studio e la Cura dei Tumori, Napoli

80336

Klinikum der Universität München, München

80337

Klinikum der Universität München, München

84112

Huntsman Cancer Hospital, Salt Lake City

Huntsman Cancer Institute, Salt Lake City

85202

Ironwood Physicians P.C dba Ironwood Cancer & Research Centers, Mesa

85206

Ironwood Physicians P.C dba Ironwood Cancer & Research Centers, Mesa

85224

Ironwood Physicians P.C dba Ironwood Cancer & Research Centers, Chandler

85297

Ironwood Physicians P.C dba Ironwood Cancer & Research Centers, Gilbert

85304

Palo Verde Hematology Oncology, Glendale

85306

Arizona Center for Cancer Care, Glendale

85323

Arizona Center for Cancer Care, Avondale

85338

Western Regional Medical Center, Inc., Goodyear

85374

Arizona Center for Cancer Care, Surprise

85719

The University of Arizona Cancer Center- North Campus, Tucson

85724

The University of Arizona Cancer Center, Tucson

86001

Arizona Oncology Associates, PC- HAL, Flagstaff

86314

Arizona Oncology Associates, PC- HAL, Prescott Valley

86336

Arizona Oncology Associates, PC- HAL, Sedona

89052

Comprehensive Cancer Centers of Nevada, Henderson

Comprehensive Cancer Centers of Nevada, Las Vegas

89074

Comprehensive Cancer Centers of Nevada, Henderson

89128

Comprehensive Cancer Centers of Nevada, Las Vegas

89169

Comprehensive Cancer Centers of Nevada, Las Vegas

90033

Keck Hospital of USC, Los Angeles

LAC & USC Medical Center, Los Angeles

USC/Norris Comprehensive Cancer Center, Los Angeles

90095

UCLA Hematology Oncology, Los Angeles

90232

Administrative Management Only: Translational Research Management, Culver City

90404

UCLA Hematology/Oncology - Santa Monica, Santa Monica

90505

Torrance Health Association, DBA Torrance Memorial Physician Network/Cancer Care Associates, Torrance

Torrance Memorial Physician Network-Cancer Care, Torrance

91010

City of Hope, Duarte

91030

City of Hope, South Pasadena

91105

UCLA Hematology/Oncology - Pasadena, Pasadena

91204

Global Research Management, Glendale

91307

Wellness Oncology & Hematology, West Hills

91361

UCLA Hematology - Oncology Clinic - Westlake Village, Westlake Village

92037

UC San Diego Medical Center-La Jolla, La Jolla

92093

UC San Diego Moores Cancer Center, La Jolla

92103

UC San Diego Medical Center-Hillcrest, San Diego

92705

Breastlink Medical Group, Inc., Santa Ana

92835

St. Jude Hospital Yorba Linda DBA St. Joseph Heritage Healthcare, Fullerton

92868

Breastlink Medical Group, Inc., Orange

Hematology Oncology Medical Group of Orange County, Inc. (HOMG), Orange

The Center for Cancer Prevention and Treatment at St. Joseph Hospital of Orange, Orange

93309

CBCC Global Research Inc. at Comprehensive Blood and Cancer Center, Bakersfield

93401

San Luis Obispo Oncology and Hematology Health Center/Pacific Central Coast Health Centers, San Luis Obispo

93454

Central Coast Medical Oncology Corporation, Santa Maria

94115

University of California, San Francisco: Helen Diller Comprehensive Cancer Center, San Francisco

95123

"U.O. di Oncologia Medica P.O. Policlinico G. Rodolico", Catania

98104

Swedish Cancer Institute, Seattle

Swedish Medical Center First Hill IDS Pharmacy, Seattle

98122

Swedish Medical Center, Seattle

100337

Spitalul Municipal Ploiesti, Ploieşti

115478

FSBSI Russian Cancer Research Center n.a.NN Blokhin, Moscow

188663

GBUZ Leningrad regional oncological dispensary, Village Kuzmolovsky

197022

"Saint Petersburg GBUZ City Clinical Oncology Dispensary", Saint Petersburg

197758

FGBU Russian Research Center for Radiology and Surgical Technologies, Village Pesochny

198255

Saint Petersburg GBUZ City Clinical Oncology Dispensary, Saint Petersburg

308010

OGBUZ Belgorod Oncology Dispensary, Belgorod

309504

OGBUZ Belgorod Oncology Dispensary, Stariy Oskol

355047

"GBUZ of Stavropol Territory Stavropol Regional Clinical Oncology Dispensary", Stavropol

357340

"FGBUZ Clinical Hospital 101 of the Federal Medical and Biological Agency", Lermontov

357502

"GBUZ of Stavropol Territory Pyatigorsk Oncology Dispensary", Pyatigorsk

450054

GBUZ Republican Clinical Oncology Dispensary of Ministry of Health of the Republic of Bashkortostan, Ufa

454087

GBUZ Chelyabinsk regional clinical center of oncology and nuclear medicine, Chelyabinsk

540142

Spitalul Clinic Judetean Mures, Tg. Mures

720237

"Spitalul Judetean de Urgente Sf. Ioan cel Nou", Suceava

04011

Maine Center for Cancer Medicine, dba: New England Cancer Specialists, Brunswick

04043

Maine Center for Cancer Medicine, dba: New England Cancer Specialists, Kennebunk

04074

Maine Center for Cancer Medicine, dba: New England Cancer Specialists, Scarborough

08903

Rutgers Cancer Institute of New Jersey, New Brunswick

V1Y 5L3

British Columbia Cancer Agency - Sindi Ahluwalia Hawkins Centre for the Southern Interior, Kelowna

V3V 1Z2

British Columbia Cancer Agency - Fraser Valley Centre, Surrey

L4M 6M2

Royal Victoria Regional Health Centre, Barrie

K7L 2V7

Cancer Centre of Southeastern Ontario @ Kingston Health Sciences Centre, Kingston

L1G 2B9

Lakeridge Health Oshawa, R.S. McLaughlin Durham Regional Cancer Centre, Oshawa

K1H 8L6

The Ottawa Hospital Cancer Centre, General Campus, Ottawa

L2S 0A9

Niagara Health System Walker Family Cancer Center, St. Catharines

M4C 3E7

Toronto East General Hospital, Toronto

M4N 3M5

Sunnybrook Research Institute, Toronto

M5G 2M9

Princess Margaret Cancer Centre, Toronto

H3T 1E2

Jewish General Hospital, Montreal

04103

Universitaetsklinikum Leipzig AoeR, Leipzig

Zentrum fuer Radiologie und Nuklearmedizin am Johannisplatz, Leipzig

Unknown

Bon Secours Hospital, Cork

00168

Farmacia - Fondazione Policlinico Universitario A. Gemelli, Roma

Fondazione Policlinico Universitario A. Gemelli, Roma

05100

S.C. Oncologia, A.O.S. Maria, Terni

464-8681

Aichi Cancer Center Hospital, Nagoya

277-8577

National Cancer Center Hospital East, Kashiwa

791-0280

National Hospital Organization Shikoku Cancer Center, Matsuyama

362-0806

Saitama Cancer Center, Kita-adachi-gun

260-8717

Chiba Cancer Center, Chiba

811-1395

National Hospital Organization Kyushu Cancer Center, Fukuoka

892-0833

Hakuaikai Medical Corporation Sagara Hospital, Kagoshima

540-0006

National Hospital Organization, Osaka

6229 HX

Academisch Ziekenhuis Maastricht, Maastricht

6162 BG

Orbis Medisch Centrum, Sittard-Geleen

5042AD

TweeSteden Ziekenhuis, Tilburg

2333ZA

Leids Universitair Medisch Centrum, Leiden

3083 AN

Ikazia Ziekenhuis, Rotterdam

2545 AA

Haga Ziekenhuis, The Hague

1400-038

Champalimaud Cancer Center/ Breast Unit, Lisbon

4200-072

Instituto Português de Oncologia, Porto

011464

Spitalul Clinic CF nr.2 Bucuresti, Bucharest

463-707

Seoul National University Bundang Hospital, Seongnam-si

03080

Seoul National University Hospital, Seoul

05505

Asan medical Center, Seoul

135-710

Samsung Medical Center, Seoul

PO6 3LY

Queen Alexandra Hospital, Portsmouth Hospitals NHS Trust Portsmouth Haematology and Oncology Centre, Portsmouth

CF14 2TL

Velindre Cancer Centre, Cardiff

S10 2JF

Royal Hallamshire Hospital, Sheffield

S10 2SJ

Sheffield Teaching Hospitals NHS Foundation Trust, Weston Park Hospital, Sheffield

SW3 6JJ

The Royal Marsden NHS Foundation Trust, London

SM2 5PT

The Royal Marsden NHS Foundation Trust, Sutton

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

lead

Pfizer

INDUSTRY