5
Participants
Start Date
August 31, 2013
Primary Completion Date
October 31, 2014
Study Completion Date
November 30, 2014
naloxone intranasal
If bioavailability is 20% or 50 %, the dose will be equivalent to the clinical range 0.4 - 1.0 mg given parenterally
naloxone intravenous
The parenteral dose reflects clinically used doses for overdoses (0.4 - 1.0 mg). A washout period of at least 3 days between each intervention. IV naloxone (Naloxone B. Braun 0.4mg/ml) administered slowly over 1-2 min in the recumbent position
Department of circulation and medical imaging, NTNU, Trondheim
St. Olavs Hospital
OTHER
University of Iceland
OTHER
Norwegian University of Science and Technology
OTHER