Apixaban for the Reduction of Thrombo-Embolism in Patients With Device-Detected Sub-Clinical Atrial Fibrillation

PHASE4CompletedINTERVENTIONAL
Enrollment

4,012

Participants

Timeline

Start Date

May 31, 2015

Primary Completion Date

October 27, 2023

Study Completion Date

November 3, 2023

Conditions
Atrial FibrillationStroke
Interventions
DRUG

Apixaban

apixaban at a dose of 5 mg twice daily (2.5 mg twice daily if 2 or more of: age \> 80, weight ≤ 60 kg or serum creatinine ≥ 133 mmol/L)

DRUG

aspirin

aspirin 81 mg once daily

Trial Locations (130)

1000

Clinique Saint Jean-Brussels, Brussels

1011

CHUV, Lausanne

1134

Magyar Honvedseg Egeszsegugyi Kozpont, Budapest

1211

University Hospital of Geneva, Geneva

1708

Hopital Fribourgeois, site de Fribourg, Fribourg

2900

Gentofte Hospital, Hellerup

3000

University Hospitals Leuven, Leuven

3004

Barum Hospital, Vestre Viken, Drammen

3400

Hilleroed Hospital, Hilleroed

4000

CHC Saint Joseph, Liège

CHR de la Citadelle, Liège

4031

University Hospital Basel, Basel

5000

Odense University Hospital, Odense

5530

CHU Dinant-Godinne, Yvoir

6060

Grand Hopital de Charleroi, Gilly

6200

Sygehus Sonderjylland, Aabenraa

6700

Vivalia CSL St. Joseph, Arlon

8003

Hospital Del Mar, Barcelona

8230

Allami Szivkorhaz Balatonfured, Balatonfüred

8500

AZ Groeninge, Kortrijk

8800

AZ Delta, Roeselare

Hjertemedicinsk Forskning, RH Viborg, HEM, Viborg

9000

Aalborg University Hospital, Dept of Cardiology, Aalborg

9007

Kantonsspital St Gallen, Sankt Gallen

9300

Onze Lieve Vrouw Ziekenhuis, Aalst

12205

St. Peter's Health Partners Medical Association, PC, Albany

14021

IKEM Institute for Clinical and Experimental Medicine, Prague

15006

Complexo Hospitalario Universitario A Coruna, A Coruña

15706

Hospital Clinico Santiago de Compostela, Santiago de Composte

17033

Pennsylvania State University, Hershey

17602

Research Institute of LG Health / Penn Medicine, Lancaster

20871

Cardiologia-A.O. Desio e Vimercate - Presisio di Vimercat, Vimercate

21005

Hospital Juan Ramon Jimenez, Huelva

22020

Ospedale Sant'Anna, San Fermo Della Batt

22042

Virginia Heart, Falls Church

22291

Asklepios Klinik Barmbek, Hamburg

27610

WakeMed, Raleigh

28040

Hospital Clinico San Carlos, Unidad De Arritmias, Madrid

Hospital Universitario Fundacion Jimenez Diaz, Madrid

28203

Carolinas Healthcare System, Charlotte

28222

Hospital Puerta de Hierro Majadahonda, Majadahonda

29603

Agencia Sanitaria Costa del Sol- Hospital Costa del Sol, Marbella

30800

Rafael Mendez Universitary Hospital, Lorca

31008

Clinica Universidad de Navarra, Pamplona

32501

Langhorne Cardiology Consultants, Inc., Pensacola

34102

Naples Interventional Cardiac Electrophysiology, Naples

34129

University and Hospital of Trieste, Trieste

37075

University Medicine Gottingen, Göttingen

39100

Bolzano Regional Hospital, Dept of Cardiology, Bolzano

40133

Ospedale Maggiore, Cardiologia Dept., Bologna

40138

S.Orsola-Malpighi, Bologna

41124

Azienda Ospedaliero-Univeritaria Di Modena-Policlinico, Modena

42304

One Health Cardiology, Owensboro Health, Inc., Owensboro

44195

Cleveland Clinic, Cleveland

46010

Hospital Clinico Universitario de Valencia, Valencia

47003

Hospital Clínico Universitario de Valladolid, Valladolid

48197

Michigan Heart, Ypsilanti

48912

Sparrow Clinical Research Institute, Lansing

55131

Katholisches Klinikum Mainz, Mainz

59901

Glacier View Cardiology, Kalispell

60126

AOU Ospedali Riuniti, Ancona

60590

Johann Wolfgang Goethe University Hospital Frankfurt, Frankfurt am Main

63136

St. Louis Heart and Vascular, St Louis

65212

University of Missouri Health System, Columbia

66421

Universitatsklinikum des Saarlandes, Homburg/Saar

72076

Universitaetsklinikum Tuebingen, Kardiologie, Tübingen

72205

St. Vincent Heart Clinic, Little Rock

80012

Aurora Denver Cardiology Associates, Aurora

80035

Hospital Santa Maria Della Pieta, Nola

85206

Cardiovascular Associates of Mesa, PC, Mesa

94939

Cardiovascular Associates of Marin and San Francisco Medical, Larkspur

02111

Tufts Medical Center, Boston

08103

The Cooper Health System, Camden

07601

Hackensack University Medical Center, Hackensack

07450

The Valley Hospital, Ridgewood

T2N 2T9

University of Calgary Foothills Hospital, Calgary

T5H 3V9

Royal Alexandra Hospital, Edmonton

T6G 2B7

University of Alberta Hospital, Edmonton

T6L 5X8

Grey Nuns Hospital, Edmonton

V6E 1M7

Heart Rhythm Research Office - St. Paul's Hospital, Vancouver

V8T 1Z4

Victoria Cardiac Arrhythmia Trials, Inc., Victoria

R2H 2A6

St. Boniface Hospital, Winnepeg

Unknown

Capital District Health Authority, Halifax

London Health Sciences Centre, London

Southlake Regional Health Centre, Newmarket

Oakville Cardiologists, Oakville

University of Ottawa Heart Institute, Ottawa

St. Michael's Hospital, Toronto

Sunnybrook Hospital, Toronto

Institute Universitaire de Cardiologie and de Pneumonologie, Laval

CHUM - Hotel Dieu, Montreal

Hopital Sacre-Coeur de Montreal, Montreal

Montreal Heart Institute, Montreal

CHUS - Sherbrooke, Sherbrooke

P3E 5J1

Health Sciences North, Greater Sudbury

L8L 2X2

Hamilton General Hospital, Hamilton

N2M 1B2

St. Mary's General Hospital, Kitchener

H3G 1A4

McGill University Health Centre, Montreal

G8Z 3R9

Ciusss McQ, Trois-Rivières

DK-8200

Aarhus Unniversity Hospital, Skejby, Aarhus

09113

MVZ am Kuchwald GmbH, Chemnitz

01099

Zentrum fur klinische Prufungen in der Facharztzentrum Dresd, Dresden

H-1122

Semmelweis University, Budapest

00122

Ospedale G.B. Grassi, Rome

7207 AE

Gelre Ziekenhuis, Zutphen

6419 PC

Atrium Orbis Heerlen, Heerlen

4818 CK

Amphia Hospital Breda, Breda

8441 PW

Ziekenhuis Tjongerschans, Heerenveen

3083 AN

Ikazia Ziekenhuis, Rotterdam

1034 CS

BovenIJ Ziekenhuis, Amsterdam

6815 AD

Hospital Rijnstate, Arnhem

7416 SE

Deventer Hospital, Cardiology Research, Deventer

6721 JT

Hospital Gelderse Vallei, Ede

7824 AA

Treant Hospital Department Cardiology, Emmen

4462 RA

Admiraal de Ruyter Ziekenhuis, Goes

7909 AA

Treant Hospital - Bethseda, Hoogeveen, Hoogeveen

4708 AE

Bravis Ziekenhuis, locatie Roosendaal, Roosendaal

5022 GC

(ETZ) Elisabeth Tweesteden Hospital, Tilburg

5504 DB

Máxima Medisch Centrum, Veldhoven

0450

Oslo University Hospital - Ulleval, Oslo

03010

Hospital General Universitario de Alicante, Alicante

DT12JY

Dorset County Hospital NHS Foundation Trust, Dorchester

RG24 9NA

Hampshire Hospitals (NHS Foundation Trust), Basingstoke

PO6 3LY

Portsmouth Hospitals NHS Trust, Portsmouth

PA29PN

Royal Alexandra Hospital, Paisley

TF1 6TF

Shrewsbury & Telford Hospital NHS, Shropshire

FY3 8NR

Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool

G51 4TF

Queen Elizabeth University Hospital, Glasgow

L14 3PE

Liverpool Heart and Chest Hospital, Liverpool

NE7 7DN

Freeman Hospital, Newcastle upon Tyne

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

collaborator

Pfizer

INDUSTRY

collaborator

Medtronic

INDUSTRY

collaborator

Canadian Institutes of Health Research (CIHR)

OTHER_GOV

lead

Population Health Research Institute

OTHER

NCT01938248 - Apixaban for the Reduction of Thrombo-Embolism in Patients With Device-Detected Sub-Clinical Atrial Fibrillation | Biotech Hunter | Biotech Hunter