Rituximab Plus Lenalidomide for Patients With Relapsed / Refractory Indolent Non-Hodgkin's Lymphoma (Follicular Lymphoma and Marginal Zone Lymphoma)

PHASE3CompletedINTERVENTIONAL
Enrollment

358

Participants

Timeline

Start Date

November 21, 2013

Primary Completion Date

June 22, 2018

Study Completion Date

January 26, 2022

Conditions
Lymphoma, Non-Hodgkin
Interventions
DRUG

Rituximab

Rituximab 375mg/m\^2 IV every week in Cycle 1 (Days 1, 8, 15 and 22) on Day 1 of every 28 day cycle from Cycles 2 to 5

DRUG

Lenalidomide

Lenalidomide 20mg by mouth (PO) daily on Days 1 to 21 every 28 days up to 12 cycles

DRUG

Placebo

Placebo (identical matched capsule) PO daily on Days 1 to 21 every 28 days

Trial Locations (160)

5530

CHU Mont -Godinne, Yvoir

8000

AZ St-Jan Brugge Oostende AV, Bruges

8500

AZ Groeninge, Kortrijk

9000

Local Institution - 371, Ghent

UZ Gent, Ghent

10065

Weill Cornell Medical College, New York

12203

Charite - Universitaetsmedizin Berlin Charité - Campus Benjamin Franklin, Berlin

13210

SUNY Upstate Medical University, Syracuse

13353

Charite - Universitaetsmedizin Berlin Campus Virchow Klinikum, Berlin

14004

Hospital Universitario Reina Sofia, Córdoba

Local Institution - 314, Córdoba

20070

Pamukkale University Medical Faculty, Denizli

20141

Istituto Europeo di Oncologia - IEO, Milan

20162

Ospedale Niguarda Ca Granda, Milan

26789

Onkologische Schwerpunktpraxis Leer - Emden, Leer

26953

Centre Hospitalier de Valence, Valence

27157

Wake Forest Baptist Health, Winston-Salem

27310

Gaziantep University, Gaziantep

28031

Hospital Universitario Infanta Leonor, Madrid

28040

Hospital Universitario Fundacion Jimenez Diaz, Madrid

29303

Spartanburg Regional Healthcare System - Gibbs Cancer Center & Research Institute, Spartanburg

29603

Hospital Costa del Sol, Marbella

Local Institution - 315, Marbella

29607

St Francis Hospital, Greenville

29609

CHRU de Brest - Hopital Morvan, Brest

30008

Hospital Morales Meseguer, Murcia

Local Institution - 318, Murcia

33081

Centro di Riferimento Oncologico - IRCCS, Aviano (PN)

33705

Florida Cancer Specialists North Region Sarah Cannon Research, St. Petersburg

34840

Marmara University, Istanbul

35340

Dokuz Eylul University Izmir, Izmir

36604

Mitchell Cancer Center, University of South Alabama, Mobile

37007

Hospital Universitario de Salamanca, Salamanca

Local Institution - 311, Salamanca

37203

Sarah Cannon Research Inst, Nashville

40138

A.O.U. di Bologna Policlinico S.Orsola-Malpighi, Bologna

40202

University of Louisville, J.G. Brown Cancer Center, Louisville

41013

Hospital Universitario Virgen Del Rocio, Seville

41063

Kliniken Maria Hilf GmbH, Mönchengladbach

41380

Kocaeli Derince Training and Research Hospital, Umuttepe Kocaeli

43100

Azienda Ospedaliero-Universitaria di Parma, Parma

45242

Oncology Hematology Care Sarah Cannon Research, Cincinnati

47014

Istituto Scientifico Romagnolo Per Lo Studio e La Cura Dei Tumori (I.R.S.T.), Meldola

47900

Ospedale degli Infermi di Rimini, Rimini

48075

Providence Cancer Institute, Southfield

48121

Ospedale di Ravenna, Ravenna

49033

CHU d'Angers, Angers

50309

Iowa Oncology Research Association, Des Moines

55139

19 Mayis Medical Faculty - Samsun, Samsun

55905

Mayo Clinic, Rochester

56303

Coborn Cancer Center at the St. Cloud Hospital, Saint Cloud

60488

Krankenhaus Nordwest, Frankfurt

61615

Illinois Cancer Care, P.C., Peoria

64239

Tel-Aviv Sourasky Medical Center, Tel Aviv

66046

CH Perpignan - Hopital Saint-Jean, Perpignan

70852

Fakultni Nemocnice Ostrava, Klinika hematoonkologie,, Ostrava

75010

Hopital Saint-Louis, Paris

76012

Arlington Cancer Center, Arlington

76121

U.O.C. Ematologia, Barletta

77030

MD Anderson Cancer Center, Houston

78052

Klinkum der Stadt Villingen-Schwenningen GmbH, Villingen-Schwenningen

80131

"IRCCS- Istituto Nazionale per lo Studio e la Cura dei Tumori, Fondazione G. Pascale", Napoli

84101

Soroka University Medical Center, Beersheba

85306

Arizona Center for Cancer Care, Glendale

86021

CHU de Poitiers, Poitiers

87102

University of New Mexico, Albuquerque

89100

Azienda Ospedaliera Bianchi-Melacrino-Morelli, Reggio Calabria

90146

Az. Osp. Vincenzo Cervello, Palermo

Casa di Cura La Maddalena, Palermo

91120

Hadassah University Hospital, Jerusalem

91750

Wilshire Oncology Medical Group, Inc, La Verne

92025

Southwest Cancer Care Medical Group, Escondido

92056

North County Hematology Oncology (NCHO) - TRM, LLC., Oceanside

Wellness Hematology Oncology, West Hills

92868

Hematology-Oncology Medical Group of Orange County, Inc., Orange

93009

Centre Hospitalier Universitaire d'Avicennes, Bobigny

93454

Central Coast Medical Oncology Corporation, Santa Maria

95124

Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione Garibaldi - Nesima, Catania

95817

UC Davis Medical Center, Sacramento

97213

Local Institution - 028, Portland

Providence Portland Medical Center, Portland

98405

Northwest Medical Specialties PLLC, Tacoma

100044

Peking University People's Hospital, Beijing

100071

307 Hospital of PLA, Beijing

100142

Beijing Cancer Hospital, Beijing, PR

100730

Peking Union Medical College Hospital, Beijing

115478

Russian Academy of Medical Sciences Institution, Moscow

125101

Moscow State Medical Institution Municipal Clinical Hospital n.a. S.P. Botkin, Moscow

197022

St. Petersburg Pavlov State Medical University, Saint Petersburg

197341

Federal Centre of Heart, Blood and Endocrinology of Rosmed technlologies V.A. Almazov, Saint Petersburg

200032

Cancer Hospital, Fudan University, Shanghai

210029

Jiangsu Province Hospital The First Hospital affiliated with Nanjing Medical University, Nanjing

215006

The First Affiliated Hospital of Soochow University, Suzhou

300020

Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin

300053

The Ministry of Health and Social Development of the Tula region state institution Health Tula regio, Tula

300060

Tianjin Medical University Cancer Institute and Hospital, Tianjin

310003

The First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou

310006

Local Institution - 604, Hangzhou

350001

Fujian Medical University Union Hospital, Fuzhou

410013

The Third Xiangya hospital of central south university, Changsha

510060

Sun Yat-sen University Cancer Center, Guangzhou

510080

Guangdong General Hospital, Guangzhou

Local Institution - 600, Guangzhou

610041

West China Hospital of Sichuan University, Chengdu

660022

Krasnoyarsk Regional Clinical Hospital, Krasnoyarsk

710032

Xijing Hospital, Xi'an

1350063

Local Institution - 700, Kōtoku

7200001

Chugoku Central Hospital, Hiroshima

94904-2007

Marin Oncology Associates, Greenbrae

06489

Cancer Center of Central Connecticut, Southington

03246

LRG Healthcare Oncology Clinic, Laconia

03106

NH Oncology - Hematology, PA, Hooksett

07601

The Cancer Center at Hackensack University Medical Center, Hackensack

07962

Hematology-Oncology Associates of Northern NJ, Morristown

90035-001

Associacao Hospitalar Moinhos de Vento Hospital Moinhos de Vento, Porto Alegre

90035-903

Hospital de Clínicas de Porto Alegre, Porto Alegre

90610-000

Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRS, Porto Alegre

90740-340

Associacao Educudora Sao Carlos AESC Hospital Giovanni Battista HGB Hospital Mae de Deus Center, Porto Alegre

14784-400

Fundacao Pio XII - Hospital de Cancer de Barretos, Barretos

17210-080

Hospital Dr. Amaral Carvalho/ Hospital Amaral Carvalho Jaú, Jau/SP

20231-130

MS INCA HC I Hospital do Cancer I, Rio de Janeiro

01308 050

Sociedade Beneficente de Senhoras Hospital Sirio Libanes, São Paulo

01321-001

Real e Benemerita Associacao Portuguesa de Beneficencia, São Paulo

01509-900

Fundação Antonio Prudente - AC Camargo Câncer center, São Paulo

Unknown

Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai

625 00

Interni hematoonkologicka klinika, Brno

500 05

Fakultni nemocnice Hradec Kralove, IV.interni hematologicka klinika, Hradec Králové

100 34

Fakultni nemocnice Kralovske Vinohrady, Interni hematologicka klinika, Prague

128 08

Local Institution - 534, Prague

Vseobecna Fakultni Nemocnice v Praze, Prague

00189

Azienda Ospedaliera S. Andrea - Università La Sapienza, Roma

Local Institution - 340, Roma

852-8511

Local Institution - 708, Nagasaki

The Japanese Red Cross Nagasaki Genbaku Hospital, Nagasaki

105-8470

Local Institution - 709, Minato-ku

Toranomon Hospital, Minatoku

104-0045

National Cancer Center Hospital, Chūōku

277-8577

National Cancer Center Hospital East, Kashiwa

650-0047

Kobe City Medical Center General Hospital, Kobe

135-8550

The Cancer Institute Hospital of Japanese Foundation For Cancer Research, Kōtoku

602-8566

University Hospital, Kyoto Prefectural University of Medicine, Kyoto

460-0001

Nagoya Medical Center,Division of Hematology/Oncology, Nagoya

980-8574

National University Corporation Tohoku University, Tohoku University Hospital, Sendai

30-510

Malopolskie Centrum Medyczne S.C., Krakow

02-776

Instytut Hematologii i Transfuzjologii w Warszawie, Warsaw

Local Institution - 514, Warsaw

02-781

Centrum Onkologii, Instytut im. Marii Sklodowskiej-Curie, Warsaw

Local Institution - 513, Warsaw

1099-023

Instituto Portugues de Oncologia de Lisboa, Francisco Gentil, Lisbon

Local Institution - 330, Lisbon

4200-072

Instituto Portugues de Oncologia do Porto, Francisco Gentil, Porto

Local Institution - 331, Porto

00918

Hospital Auxilio Muto Centro de Cancer, San Juan

08041

Hospital de la Santa Creu i Sant Pau, Barcelona

01330

Cukurova University Medical Faculty Balcali Hospital, Adana

06100

Hacettepe Universitesi, Ankara

BN21 2UD

Eastbourne District General Hospital, Eastbourne

L7 8XP

Royal Liverpool University Hospital, Prescot Street, Liverpool

EC1M 6BQ

Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London

SS0 0RY

Southend University Hospital NHS Foundation Trust, Prittlewell Chase, Westcliff-on-Sea

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Celgene

INDUSTRY