Phase II Part 2 Expansion of Oral Rigosertib in Combination With Azacitidine

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

45

Participants

Timeline

Start Date

August 31, 2013

Primary Completion Date

December 8, 2020

Study Completion Date

February 16, 2021

Conditions
Myelodysplastic SyndromeAcute Myeloid LeukemiaChronic Myelomonocytic Leukemia
Interventions
DRUG

oral rigosertib

Oral rigosertib will be administered twice a day in fasting conditions for weeks 1, 2, and 3 of a 4-week cycle.

DRUG

Azacitidine

Starting on Day 1 of second week (Day 8) of the cycle, azacitidine will be administered by subcutaneous injection or intravenous infusion at the labeled daily dose of 75 mg/m2, for 7 days.

Trial Locations (13)

10029

Mount Sinai Medical Center, New York

10601

White Plains Hospital Center for Cancer Care, White Plains

14263

Roswell Park Cancer Institute, Buffalo

29732

Carolina Blood and Cancer Care Associates, Rock Hill

53226

Froedtert Hospital and the Medical College of Wisconsin, Milwaukee

60612

Rush University Medical Center, Chicago

63110

Saint Louis University, St Louis

67214

Cancer Center of Kansas, Wichita

75475

Hôpital St. Louis, Paris

77030

The University of Texas MD Anderson Cancer Center, Houston

85234

Banner MD Anderson Cancer Center, Gilbert

91010

City of Hope, Duarte

92270

Desert Hematology Oncology Medical Group, Inc., Rancho Mirage

All Listed Sponsors
lead

Traws Pharma, Inc.

INDUSTRY

NCT01926587 - Phase II Part 2 Expansion of Oral Rigosertib in Combination With Azacitidine | Biotech Hunter | Biotech Hunter