Phase 1/2 Study of Enasidenib (AG-221) in Adults With Advanced Hematologic Malignancies With an Isocitrate Dehydrogenase Isoform 2 (IDH2) Mutation

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

345

Participants

Timeline

Start Date

August 27, 2013

Primary Completion Date

July 25, 2019

Study Completion Date

October 31, 2023

Conditions
Hematologic Neoplasms
Interventions
DRUG

Enasidenib

Enasidenib tablets administered orally every day of 28-day treatment cycles until disease progression or unacceptable toxicities.

Trial Locations (24)

10065

Cornell University Weill Medical College, New York

Memorial Sloan-Kettering Cancer Center - NYC, New York

31059

Local Institution - 205, Toulouse

33076

Local Institution - 202, Bordeaux

33136

University of Miami Sylvester Cancer Center, Miami

33604

Local Institution - 203, Pessac

33612

Moffitt Cancer Center, Tampa

34232

Florida Cancer Specialists, Sarasota

37203

Sarah Cannon Research Institute Drug Development Unit, Nashville

43230

Ohio State University, Gahanna

44195

Cleveland Clinic, Cleveland

55905

Mayo Clinic, Rochester

63110

Washington University, St Louis

75010

Local Institution - 204, Paris

77030

MD Anderson Cancer Center, Houston

80045

University Of Colorado Cancer Center, Aurora

94305

Stanford Cancer Center, Stanford

94805

Local Institution - 201, Villejuif

97239

Oregon Health and Science University OHSU, Portland

91010-301

City Of Hope, Duarte

60611-3008

Northwestern University, Chicago

02117

Massachusetts General Hospital, Boston

02215

Dana-Farber/Mass General Brigham Cancer Care, Inc, Boston

75390-85520

Ut Southwestern Medical Center At Dallas, Dallas

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Agios Pharmaceuticals, Inc.

INDUSTRY

lead

Celgene

INDUSTRY