MS-SMART: Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial

PHASE2CompletedINTERVENTIONAL
Enrollment

445

Participants

Timeline

Start Date

December 18, 2014

Primary Completion Date

June 14, 2018

Study Completion Date

July 4, 2018

Conditions
Secondary Progressive Multiple Sclerosis
Interventions
DRUG

Amiloride

Comparison with placebo

DRUG

Riluzole

Comparison with placebo

DRUG

Fluoxetine

Comparison with placebo

DRUG

Placebo

Placebo comparator

Trial Locations (13)

EH16 4SA

Anne Rowling Regenerative Neurology Clinic, Royal Infirmary of Edinburgh, Edinburgh

G12 OXH

Gartnavel Royal Hospital, 1055 Great Western Road, Glasgow

RH16 4EX

Brighton and Sussex University Hospitals, Haywards Heath

LS9 7TF

St James's University Hospital, Leeds

L9 7LJ

The Walton Centre, Liverpool

WC1N 3BG

The National hospital for Neurology and Neurosurgery, University College London, London

NE1 4LP

The Royal Victoria Infirmary, Newcastle

NG7 2UH

Queens Medical Centre, Nottingham

OX3 9DU

John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford

PL6 8DH

Derriford Hospital, Plymouth

S10 2JF

Royal Hallamshire Hospital, Sheffield

ST4 7LN

University Hospital of North Staffordshire, Stoke-on-Trent

TR1 3LJ

Royal Cornwall Hospital, Truro

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Medical Research Council

OTHER_GOV

collaborator

National Institute for Health Research, United Kingdom

OTHER_GOV

collaborator

National Multiple Sclerosis Society

OTHER

collaborator

University of Edinburgh

OTHER

collaborator

Queen Mary University of London

OTHER

collaborator

Keele University

OTHER

collaborator

University of Sheffield

OTHER

collaborator

University of Leeds

OTHER

collaborator

University of Warwick

OTHER

lead

University College, London

OTHER

NCT01910259 - MS-SMART: Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial | Biotech Hunter | Biotech Hunter