702
Participants
Start Date
October 31, 2013
Primary Completion Date
September 11, 2018
Study Completion Date
September 11, 2018
Prompt Laser
Focal/grid laser performed at baseline and as needed during follow-up
Prompt aflibercept
Intravitreal injection of 2.0mg aflibercept performed on the day of randomization and up to every 4 weeks using defined treatment criteria
Deferred laser
Focal/grid laser is initiated while receiving anti-VEGF injections only if certain criteria are met
Deferred aflibercept
Intravitreal injection of 2.0mg aflibercept performed once certain criteria for vision loss are met and then up to every 4 weeks using defined treatment criteria
The New York Eye and Ear Infirmary/Faculty Eye Practice, New York
MaculaCare, New York
Retina-Vitreous Surgeons of Central New York, PC, Syracuse
Ross Eye Institute, SUNY Buffalo, Buffalo
Retina Associates of Western New York, Rochester
University of Rochester, Rochester
Retina Vitreous Consultants, Monroeville
University of Pennsylvania Scheie Eye Institute, Philadelphia
Elman Retina Group, P.A., Baltimore
Retina Institute of Virginia, Richmond
Virginia Commonwealth University, Dept. of Ophthalmology, Richmond
Charlotte Eye, Ear, Nose and Throat Assoc., PA, Charlotte
Western Carolina Retinal Associates, PA, Asheville
Palmetto Retina Center, West Columbia
Carolina Retina Center, Columbia
Marietta Eye Clinic, Marietta
Emory Eye Center, Atlanta
Thomas Eye Group, Sandy Springs
Southeast Retina Center, P.C., Augusta
University of Florida College of Med., Department of Ophthalmology, Jacksonville
Magruder Eye Institute, Orlando
Retina Macula Specialists of Miami, Miami
Bascom Palmer Eye Institute, Miami
Fort Lauderdale Eye Institute, Plantation
Retina Associates of Florida, P.A., Tampa
Florida Retina Consultants, Lakeland
National Ophthalmic Research Institute, Fort Myers
Center for Sight, Sarasota
Sarasota Retina Institute, Sarasota
Ocala Eye Retina Consultants, Ocala
Southeastern Retina Associates, Chattanooga
Southeastern Retina Associates, PC, Kingsport
Southeastern Retina Associates, P.C., Knoxville
Retina and Vitreous Associates of Kentucky, Lexington
Paducah Retinal Center, Paducah
Case Western Reserve University, Cleveland
Retina Associates of Cleveland, Inc., Beachwood
Raj Maturi, Indianapolis
John-Kenyon American Eye Institute, New Albany
Kellogg Eye Center, University of Michigan, Ann Arbor
Henry Ford Health System, Dept of Ophthalmology and Eye Care Services, Detroit
Retina Vitreous Center, Grand Blanc
Andersen Eye Associates, Saginaw
Retina Specialists of Michigan, Grand Rapids
Vitreo-Retinal Associates, Grand Rapids
Wolfe Eye Clinic, West Des Moines
Medical Associates Clinic, P.C., Dubuque
University of Wisconsin-Madison, Dept of Ophthalmology/Retina Service, Madison
Retina Center, PA, Minneapolis
University of Minnesota, Minneapolis
Mayo Clinic Department of Ophthalmology, Rochester
NorthShore University HealthSystem, Glenview
Illinois Retina Associates, Joliet
University Retina and Macula Associates, Oak Forest
Northwestern Medical Faculty Foundation, Chicago
University of Illinois at Chicago Medical Center, Chicago
Carle Foundation Hospital, Urbana
The Retina Institute, St Louis
Mid-America Retina Consultants, P.A., Kansas City
Retina Associates, P.A., Shawnee Mission
University of Kansas Medical Center, Dept. of Ophthalmology, Prairie Village
Retina Vitreous Center, Edmond
Retina and Vitreous of Texas, Houston
Baylor Eye Physicians and Surgeons, Houston
Retina Consultants of Houston, PA, Houston
Retinal Consultants of San Antonio, San Antonio
Valley Retina Institute, McAllen
Austin Retina Associates, Austin
Retina Research Center, Austin
Southwest Retina Specialists, Amarillo
Texas Retina Associates, Lubbock
Retina Associates of Utah, P.C., Salt Lake City
Arizona Retina and Vitreous Consultants, Phoenix
University of Arizona Medical Center/Department of Ophthalmology, Tucson
Eye Associates of New Mexico, Albuquerque
South Coast Retina Center, Long Beach
Retinal Consultants of Southern California Medical Group, Inc., Westlake Village
Southern California Desert Retina Consultants, MC, Palm Desert
Loma Linda University Health Care, Dept. of Ophthalmology, Loma Linda
Retina Consultants of Southern California, Redlands
California Retina Consultants, Santa Barbara
Bay Area Retina Associates, Walnut Creek
Retinal Diagnostic Center, Campbell
Retinal Consultants Medical Group, Inc., Sacramento
Retina Northwest, PC, Portland
Casey Eye Institute, Portland
Oregon Retina, LLP, Eugene
University of Washington Medical Center, Seattle
Spokane Eye Clinic, Spokane
Jones Eye Institute/University of Arkansas for Medical Sciences, Little Rock
Retina Group of New England, New London
New England Retina Associates, Norwich
Wilmer Eye Institute at Johns Hopkins, Baltimore
Joslin Diabetes Center, Boston
Vitreo-Retinal Associates, PC, Worcester
Eyesight Ophthalmic Services, PA, Portsmouth
The Institute of Ophthalmology and Visual Science (IOVS), Newark
Retinal and Ophthalmic Consultants, PC, Northfield
University of North Carolina, Chapel Hill
Family Eye Group, Lancaster
Alberta Retina Consultants, Edmonton
University Health Network - Toronto Western Hospital, Toronto
UBC/VCHA Eye Care Centre, Vancouver
Lead Sponsor
Regeneron Pharmaceuticals
INDUSTRY
National Eye Institute (NEI)
NIH
National Institutes of Health (NIH)
NIH
Jaeb Center for Health Research
OTHER