921
Participants
Start Date
September 12, 2013
Primary Completion Date
November 9, 2016
Study Completion Date
September 3, 2024
LGX818
LGX818- Orally 100 mg and 50 mg capsules
MEK162
MEK162- Orally 15 mg tablets
vemurafenib
Tablets in bottles or blisters 240 mg
Mary Potter Oncology Centre, Pretoria
Policlinico Universitario Campus Biomedico Di Roma, Rome
Oslo universitetssykehus HF, Utprøvingsenheten, Oslo
Oslo universitetssykehus HF, Oslo
The Alfred Hospital, Prahran
Hospital General Universitario Dr. Balmis, Alicante
Inselspital Bern, Bern
Debreceni Egyetem Klinikai Kozpont, Debrecen
Princess Alexandra Hospital, Woolloongabba
Tasman Oncology Research, Southport
The Queen Elizabeth Hospital, Woodville
Sir Charles Gairdner Hospital, Nedlands
Gazi University Medical Faculty Gazi Hospital, Ankara
Hospital Clinic de Barcelona, Barcelona
Hospital de la Santa Creu I Sant Pau, Barcelona
Universitätsspital Zürich, Zurich Flughafen
Fondazione del Piemonte per l'Oncologia (IRCCS), Candiolo
Charite-Universitaetsmedizin Berlin, Berlin
Hospital Universitario de Jerez, Jerez de la Frontera
Medica Sur, S. A. B de C. V. (Centro de Investigación Farmacológica y Biotecnológica CIF-BIOTEC), México
Instituto Nacional de Cancerologia, Mexico City
Investigational Drug Service, Department of Pharmacy (Investigational Product), Rochester
University of Rochester Medical Center - PPDS, Rochester
Hospital Universitario A Coruña, A Coruña
University of Pittsburgh Cancer Institute, Pittsburgh
IRCCS Az. Osp. Universitaria San Martino- IST, Genoa
Istituto Oncologico Veneto - I.R.C.C.S., Padua
Hospital Universitario Virgen de las Nieves, Granada
Onkologikoa, Donostia / San Sebastian
Istituto Nazionale Dei Tumori, Milan
Istituto Europeo Di Oncologia, Milan
Virginia Cancer Specialists, PC, Gainesville
ASST Grande Ospedale Metropolitano Niguarda - Presidio Ospedaliero Ospedale Niguarda, Milan
Universitätsklinik Hamburg Eppendorf, Hamburg
Azienda Ospedaliera San Gerardo, Monza
Augenarztzentrum Buxtehude, Buxtehude
Elben Klinken Stade ? Buxtehude, Buxtehude
Virginia Cancer Specialists (Leesburg) - USOR, Fairfax
Northern Virginia Ophthalmology Associates, Falls Church
Virginia Cancer Specialists, Arlington
Skanes Universitetssjukhus Lund, Lund
Virginia Cancer Specialists, PC, Alexandria
Universitatsklinikum Schleswig-Holstein, Campus Lubeck, Lübeck
Azienda Ospedaliera Ospedale Di Lecco, Lecco
University Hospital Schleswig-Holstein, Campus Kiel, Kiel
ASST Papa Giovanni XXIII - Azienda Ospedaliera Papa Giovanni XXIII, Bergamo
ASST degli Spedali Civili di Brescia - Spedali Civili di Brescia - INCIPIT - PIN, Brescia
Hospital Arnau de Vilanova, Lleida
Hospital Universitari Arnau de Vilanova, Lleida
Fondazione IRCCS Policlinico San Matteo di Pavia, Pavia
Hospital General Universitario Gregorio Maranon, Madrid
Hospital Universitario Ramon y Cajal, Madrid
Hospital Universitario 12 de Octubre, Madrid
Hospital Universitario La Paz - PPDS, Madrid
Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda
Hospital Civil (Hospital Regional Universitario de Malaga), Málaga
Hospital Clinico Universitario Virgen de la Arrixaca, El Palmar
Augenärzte am Kröpcke, Hanover
Medizinische Hochschule Hannover (Hannover Medical School), Hanover
Institut für Diagnostische und Interventionelle Radilogie, Hanover
Clinica Universidad de Navarra, Pamplona
Hospital Universitario de Navarra, Pamplona
Augen-Praxis_Minden, Minden
Institut für Diagnostische Radiologie, Neuroradiologie und Nuklearmedizin, Minden
Mühlenkreiskliniken - Johannes Wesling Klinikum Minden, Minden
Hospital Universitario Central de Asturias, Oviedo
Hopital Saint Andre Unite de Cancerologie Service de Dermatologie, Bordeaux
Azienda Sanitaria Universitaria Integrata di Udine - PO Universitario Santa Maria della Misericordia, Udine
University of Miami, Miami
University Cancer Institute, Boynton Beach
Klinikum Kassel, Kassel
Ege University Medical Faculty, Bornova
Ege University Medical aculty, Izmir
Sifa Universitesi Bornova Egitim Arastirma Hastanesi, Izmir
Clinica Oculistica, Padua
Retinal Consultants of Alabama P.C., Birmingham
UAB Callahan Eye Hospital, Birmingham
UAB Comprehensive Cancer Center, Birmingham
UAB The Kirklin Clinic, Birmingham
University of Alabama at Birmingham, Birmingham
University of Alabama at Birmingham, Birmingham
University of Tennessee Medical Center Cancer Institute, Knoxville
Hospital Universitario Nuestra Sra de La Candelaria, Santa Cruz de Tenerife
CHU de Grenoble, Grenoble
Universitätsklinikum Magdeburg A.ö.R., Magdeburg
Jackson Oncology Associates - St. Dominic Hospital, Jackson
Hattiesburg Clinic Oncology Hem, Hattiesburg
Azienda Ospedaliero Universitaria Di Bologna Policlinico S Orsola Malpighi, Bologna
Hospital Universitario Virgen del Rocio - PPDS, Seville
Hospital Nuestra Señora de Valme, Seville
Universitätsklinikum Essen, Essen
Fundacion Instituto Valenciano de Oncologia, Valencia
Goshen Center For Cancer Care, Goshen
Fachklinik Hornheide Abteilung für Internistische Onkologie und Hämatologie, Münster
Lack's Cancer Center at Mercy Health Saint Mary's, Grand Rapids
Mercy Health Hauenstein Neuroscience Center Neuro-Ophthalmology (Clinic), Grand Rapids
Retina Specialists of Michigan, Grand Rapids
CHU de Reims - Hôpital Robert Debré, Reims
Azienza Ospedaliera Universitaria Senese, Siena
Universitätsklinikum Bonn, Bonn
Augenklinik Universitätsklinikum Bonn, Bonn
Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Mainz
Azienda Ospedaliero Universitaria Pisana, Pisa
Sanford Cancer Center Oncology Clinic & Pharmacy, Sioux Falls
CHRU de Lille - Hôpital Huriet, Lille
Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona-Umberto I G.M. Lancisi G. Salesi, Torrette Site
Goethe-University Frankfurt/Main, Frankfurt am Main
Eye & Ear Infirmary- Opthalmology, Chicago
University of Illinois at Chicago, Chicago
University of Illinois Hospital and Health Sciences System - Investigational Drug Service, Chicago
University of Illinois Hospital and Health Sciences System, Chicago
University of Illinois Medical Center, Chicago
Oncology Specialists, SC, Niles
Hospital Universitario Dr. Jose Eleuterio Gonzalez, Monterrey
Universität des Saarlandes, Homburg
Nouvel Hopital Civil, Strasbourg
Nebraska Methodist Hospital, Omaha
Klinikum Mannheim Universitätsklinikum gGmbH, Mannheim
Augenklinik Universitätsklinikum Mannheim, Mannheim
University Clinic Heidelberg - PPDS, Heidelberg
University Clinic Heidelberg - PPDS, Heidelberg
Centre Léon Bérard Centre Régional de Lutte Contre Le Cancer Rhône Alpes, Lyon
Hospices Civils de Lyon - Hopital Lyon Sud, Pierre-Bénite
IRCCS Giovanni Paolo II Cancer Institute, Bari
Fakultni nemocnice Ostrava, Ostrava
Centre Hospitalier Le Mans, Le Mans
Universitätsklinikum Tübingen, Tübingen
Universitätsklinikum Tübingen, Tübingen
Highlands Oncology Group, Fayetteville
Highlands Oncology Group, Rogers
Highlands Oncology Group - Fayetteville, Springdale
Tulsa Cancer Institute PLLC, Tulsa
Hopital Lariboisiere, Paris
Institut Mutualiste Montsouris, Paris
Ophtalmologist office, Paris
Dr. Dennis B. Kay (Ophthalmologist), Dallas
Texas Oncology - Baylor Charles A. Sammons Cancer Center, Dallas
UT Southwestern Medical Center at Dallas, Dallas
Hôpital Saint louis, Paris
Klinik für Augenheilkunde, Gera
Cancun Oncology Center Galenia, Cancún
Universitaetsklinikum Freiburg, Freiburg im Breisgau
Universitätsklinikum Freiburg, Klinik für Radiologie, Freiburg im Breisgau
Rocky Mountain Cancer Centers (Williams) - USOR, Aurora
Azienda Ospedaliera Universitaria Federico II, Napoli
Istituto Nazionale Tumori IRCCS Fondazione Giovanni Pascale, Napoli
Specialty Eye Care, Parker
Rocky Mountain Cancer Centers (Williams) - USOR, Denver
Rocky Mountain Cancer Centers, Lakewood
Rocky Mountain Cancer Centers, Boulder
LMU Klinikum, München
Rocky Mountain Cancer Centers, Colorado Springs
Rocky Mountain Cancer Centers, Pueblo
Arizona Oncology Associates, Tucson
Universitätsklinikum Ulm, Ulm
Internistische Schwerpunktpraxis Kardiologie Hämatologie Onkologie, Ulm
Universitätsklinikum Ulm, Ulm
Hautklinik, Klinikum Nürnberg, Universitätsklinik der Paracelsus Medizinischen Privatuniversität, Nuremberg
Klinikum Nürnberg - Campus Nord, Nuremberg
Hadassah Medical Center - PPDS, Jerusalem
Centre Hospitalier Universitaire Ambroise Paré, Boulogne-Billancourt
UC Irvine Medical Center, Orange
Institut für Röntgendiagnostik, Regensburg
University Clinic Regensburg - PPDS, Regensburg
Klinik & Poliklinik für Augenheilkunde, Regensburg
Institut Gustave Roussy, Villejuif
Klinikum Bayreuth GmbH, Bayreuth
Universitätsklinikum Würzburg, Würzburg
Azienda Ospedaliera Civile Maria Paternò Arezzo Ragusa, Ragusa
S. C. Oncologia Medica Presidio Ospedaliero Maria Paterno Arezzo, Ragusa
Wenatchee Valley Hospital & Clinics, Wenatchee
Klinik fur Hautkrankheiten und Allergologie, Helios Hauttumorzentrum Erfurt, Helios Klinikum Erfurt, Erfurt
Hospital Universitario San Ignacio, Bogotá
Russian Oncology Research Center n a N N Blokhin, Moscow
National Cancer Centre - 30 Hospital Blvd, Singapore
Singapore General Hospital (SGH), Singapore
National Cancer Centre Singapore, Singapore
Singapore National Eye Research Centre, Singapore
Scientific Research Institute of Oncology n.a. N.N. Petrov, Saint Petersburg
Ryazan Clinical Hospital n.a. Semashko, Ryazan
Ryazan Regional Clinical Oncology Dispensary, Ryazan
Rambam Health Care Campus, Haifa
Sheba Medical Center - PPDS, Ramat Gan
Hackensack University Medical Center, Hackensack
University of Vermont Medical Center, Burlington
Fundación CENIT para la Investigación en Neurociencias, CABA
Fundación Investigar, Buenos Aires
Instituto Médico Especializado Alexander Fleming, Buenos Aires
Lake Macquarie Private Hospital, Gateshead
AMO - Assistência Multidisciplinar em Oncologia, Salvador
Instituto de Medicina Integral Professor Fernando Figueira, Recife
Associação Hospital de Caridade Ijuí, Ijuí
Hospital de Clinicas de Porto Alegre (HCPA) - PPDS, Porto Alegre
Fundação PIO XII, Barretos
Liga Norte Riograndense Contra O Cancer, Natal
INCA Instituto Nacional de Cancer, Rio de Janeiro
Hospital BP Mirante, São Paulo
Tom Baker Cancer Centre, Calgary
SunnyBrook Health Sciences Centre, Toronto
Princess Margaret Cancer Centre, Toronto
Centre Hospitalier De L'Universite De Montreal Hospital Notre Dame, Montreal
CHUM Notrea Dame Hospital, Montreal
Centre Hospitalier de l'Universite de Montreal, Montreal
McGill University Health center, Montreal
CHU de Quebec-Universite Laval - L' Hotel - Dieu de Quebec, Québec
Fakultni nemocnice Kralovske Vinohrady, Prague
Mou/Mmci - Ppds, Brno
Fakultni nemocnice Olomouc, Olomouc
General Faculty Hospital, Prague
Groupe Hospitalier Archet I Et II, Nice
Universitatsklinikum Leipzig AoR, Leipzig
University Hospital Carl Gustav Carus at the Technical University of Dresden, Dresden
Überörtliche Radiologische Gemeinschaftspraxis Dresden, Dresden
Institut für Diagnostische und Interventionelle Radiologie, Gera
SRH Wald-Klinikum Gera GmbH, Gera
Laiko General Hospital of Athens, Athens
Metropolitan Hospital, Neo Faliro
Magyar Honvédség Egészségügyi Központ, Budapest
Orszagos Onkologiai Intezet, Budapest
Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz-Rendelointezet, Szolnok
Policlinico Universitario Campus Biomedico Di Roma, Rome
Policlinico Universitario Campus Biomedico, Rome
Istituto Nazionale Tumori Regina Elena, Rome
Istituto Dermopatico dell'Immacolata IRCCS, Rome
Azienda Ospedaliera S Maria Di Terni, Terni
Kyushu University Hospital, Fukuoka
Shinshu University Hospital, Matsumoto
Niigata Cancer Center Hospital, Niigata
National Cancer Center Hospital, Chuo-ku
National Hospital Organization Osaka National Hospital, Osaka
Radboud University Nijmegen Medical Centre, Nijmegen
Amphia Ziekenhuis, Breda
Maxima Medisch Centrum, Eindhoven
VU Medisch Centrum, Amsterdam
Medisch Spectrum Twente, Enschede
Isala Zwolle, Zwolle
Medisch Centrum Leeuwarden, Leeuwarden
Medisch Spectrum Twente - Hospital, Ariënsplein Enschede
Medisch Spectrum Twente, Enschede
Universitair Medisch Centrum Groningen, Groningen
Zuyderland Medisch Centrum - Heerlen, Heerlen
Leids Universitair Medisch Centrum, Leiden
Maastricht University Medical Center, Maastricht
Erasmus MC, Rotterdam
Erasmus MC-Daniel den Hoed Oncologisch Centrum, Rotterdam
Oslo Myeloma Center - PPDS, Oslo
Centrum Medyczne MAVIT Sp. z o.o., Warsaw
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie, Warsaw
Lux Med, Warsaw
Instituto Português de Oncologia de Lisboa Francisco Gentil, E.P.E., Lisbon
Instituto Portugues de Oncologia Do Porto Francisco Gentil Epe - PPDS, Lisbon
Hospital Garcia de Orta*E.P.E., Almada
Centro Hospitalar de Lisboa Norte, E.P.E- Hospital de Santa Maria, Lisbon
Instituto Portugues de Oncologia Do Porto Francisco Gentil Epe - PPDS, Porto
Narodny onkologicky ustav - PPDS, Bratislava
POKO POPRAD, s.r.o., Poprad
Steve Biko Academic Hospital, Pretoria
Samsung Medical Center - PPDS, Gangnam-gu
Asan Medical Center - PPDS, Seoul
Seoul National University Hospital, Seoul
Severance Hospital Yonsei University Health System - PPDS, Seoul
Hospital Universitario Germans Trias i Pujol, Badalona
Cetir, Centre Mèdic, S.L, Barcelona
Centro de Oftalmologia Barraquer, Barcelona
Hospital Universitario Vall d'Hebron - PPDS, Barcelona
Gävle Sjukhus, Gävle
Sahlgrenska Universitetssjukhuset, Gothenburg
Universitetssjukhuset i Linköping, Linköping
Karolinska Universitetssjukhuset Solna, Solna
Uppsala Universitet, Uppsala
Addenbrookes Hospital, Cambridge
The Royal Marsden NHS Foundation Trust, London
Mount Vernon Hospital, Northwood
Royal Surrey County Hospital, Guildford
The Clatterbridge Cancer Centre NHS Foundation Trust, Bebington
Weston Park Hospital, Sheffield
Broomfield Hospital, Broomfield
St James University Hospital, Leeds
Royal Free Hospital, London
The Christie NHS Foundation Trust - PPDS, Manchester
Churchill Hospital, Oxford
Royal Preston Hospital - NWCRN- PPDS, Preston
Lead Sponsor
Pfizer
INDUSTRY