Nintedanib (BIBF 1120) in Mesothelioma

PHASE2/PHASE3TerminatedINTERVENTIONAL
Enrollment

545

Participants

Timeline

Start Date

September 19, 2013

Primary Completion Date

March 16, 2018

Study Completion Date

August 31, 2018

Conditions
Mesothelioma
Interventions
DRUG

Nintedanib

triple kinase inhibitor; 200mg starting dose

DRUG

Pemetrexed

backbone chemo

DRUG

Cisplatin

backbone chemo

DRUG

Cisplatin

backbone chemo

DRUG

Pemetrexed

backbone chemo

DRUG

Placebo

Nintedanib matching placebo

Trial Locations (123)

1090

AKH - Medical University of Vienna, Vienna

1200

Brussels - UNIV Saint-Luc, Brussels

2065

Northern Cancer Institute, St Leonards

2100

Rigshospitalet, København, Onkologisk afdeling, Købenahvn Ø

2298

Calvary Mater Newcastle Hospital, Waratah

2650

Edegem - UNIV UZ Antwerpen, Edegem

2800

AZ Sint-Maarten, Mechelen

3000

UZ Leuven, Leuven

3084

Austin Health, Heidelberg

3128

Box Hill Hospital, Box Hill

3199

Peninsula Haematology & Oncology, Frankston

3690

Border Onclogy Research, Wodonga

4032

The Prince Charles Hospital, Chermside

4101

Mater Cancer Care Centre, South Brisbane

4600

Klinikum Wels - Grieskirchen GmbH, Wels

6000

Perth Oncology, Perth

6009

Sir Charles Gairdner Hospital, Nedlands

8700

LKH Leoben, Leoben

9000

UNIV UZ Gent, Ghent

10000

University Clinic for Pulmonary Diseases, Zagreb

10043

Azienda Sanitaria Ospedale S. Luigi Gonzaga, Orbassano (TO)

11796

National Cancer Institute, Cairo University, Cairo

12351

Vivantes Netzwerk für Gesundheit GmbH, Berlin

12655

Nasser Institute, Cairo

13015

HOP Nord, Marseille

14033

HOP Côte de Nacre, Caen

14080

Instituto Nacional de Cancerologia, México

14165

Helios Klinikum Emil von Behring, Berlin

15121

Azienda Ospedaliera Santi Antonio e Biagio e Cesare Arrigo, Alessandria

15232

University of Pittsburgh Medical Center, Pittsburgh

16132

Istituto Nazionale per la Ricerca sul Cancro, Genova

20080

Hospital Universitario Donostia, Donostia (Gipuzkoa)

21131

Clinical Research Center Alexandria, Alexandria

21648

Medical Research Institute, Alexandria

22927

Pneumologisches Forschungsinstitut an der LungenClinic Grosshansdorf GmbH, Großhansdorf

24125

Humanitas Gavazzeni, Bergamo

26950

Eskisehir Osmangazi Üni. Sag. Uygulama ve Arastirma Has., Eskişehir

28034

Hospital Ramón y Cajal, Madrid

29010

Hospital Virgen de la Victoria, Málaga

29609

HOP Morvan, Brest

29615

Greenville Health System, Greenville

31059

HOP Larrey, Toulouse

31096

Rambam Medical Center, Haifa

31217

Centro Oncologico de Chihuahua, Chihuahua City

33000

CLI Bordeaux Nord Aquitaine, Bordeaux

33081

Centro di riferimento Oncologico, Aviano (PN)

34899

Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi, Istanbul

35120

Dr.Suat Seren EAH, Izmir

35249

University of Alabama at Birmingham, Birmingham

41013

Hospital Virgen del Rocío, Seville

46010

Hospital Clínico de Valencia, Valencia

48903

Hospital Universitario de Cruces, Barakaldo (Vizcaya)

49100

Rabin Medical Center Beilinson, Petah Tikva

50180

Centro Oncologico Estatal ISSEMYM, Toluca

53100

A.O.U. Senese Policlinico Santa Maria alle Scotte, Siena

59000

HOP Calmette, Lille

64239

Sourasky Medical Center, Tel Aviv

66421

Universitätsklinikum des Saarlandes, Homburg/Saar

69126

Thoraxklinik-Heidelberg gGmbH am Universitätsklinikum Heidelberg, Heidelberg

69230

HOP Lyon Sud, Pierre-Bénite

70839

Klinik Schillerhöhe GmbH, Gerlingen

74245

Klinik, Löwenstein, Löwenstein

77030

The University of Texas MD Anderson Cancer Center, Houston

78217

Texas Oncology-San Antonio Northeast, San Antonio

78503

Texas Oncology - McAllen, McAllen

83800

HOP HIA Saint-Anne, Toulon

89052

Comprehensive Cancer Centers of Nevada, Henderson

94115

University of California San Francisco, San Francisco

94805

INS Gustave Roussy, Villejuif

99216

Cancer Care Northwest Centers, PS, Spokane Valley

115478

"FSBI N.N Blokhin Med.Res.Cent.Onc.MoH of RF", Moscow

197022

1stPavlov St.Med.Univ.St.-Petersburg Res.Inst., Saint Petersburg

197758

"FSBI N.N. Petrov National Medical Research Center of Oncology of MoH of RF", Saint Petersburg

420029

"St.Auton.Heal.Inst.Rep.Clin.Onc.Disp.of MoH of Rep. Tatarstan", Kazan'

450054

SBI HC-Rep.Clin.Onc.Disp.MoH.Rep.Bashkortostan, Ufa

454087

"St.Budg.Heal.Inst.Chelyabinsk Reg.Clin.Cen.Onc&Nucl.Med", Chelyabinsk

7630372

Orlandi Oncologia, Vitacura

8420383

Centro Internacional de Estudios Clínicos - CIEC, Recoleta

80120-4413

Rocky Mountain Cancer Centers, Littleton

C1180AAX

Sanatorio Güemes, Ciudad Autónoma de Bs As

C1426ANZ

Instituto Medico Especializado Alexander Fleming, Ciudad Autónoma de Bs As

X5004FHP

Clínica Universitaria Reina Fabiola, Córdoba

B3H 1V7

QEII Health Sciences Centre (Dalhousie University), Halifax

P3E 5J1

Health Sciences North, Greater Sudbury

M5G 2M9

Princess Margaret Cancer Centre, Toronto

GLV 4G5

IUCPQ (Laval University), Québec

625 00

University Hospital Brno, Brno

779 00

University Hospital Olomouc, Olomouc

807-8556

University Hospital of Occupational and Environmental Health, Fukuoka, Kitakyushu

660-8550

Hyogo Prefectural Amagasaki General Medical Center, Hyogo, Amagasaki

663-8501

Hyogo College of Medicine Hospital, Hyogo, Nishinomiya

238-8558

Yokosuka Kyosai Hospital, Kanagawa , Yokosuka

702-8055

Japan Labour Health and Safety Organization Okayama Rosai Hospital, Okayama, Okayama

589-8511

Kindai University Hospital, Osaka, OsakaSayama

540-0008

Otemae Hospital, Osaka, Osaka

113-8431

Juntendo University Hospital, Tokyo, Bunkyo-ku

7513 ER

Medisch Spectrum Twente, Enschede

6419 PC

Zuyderland Medisch Centrum, Heerlen

3015 CE

Erasmus Medisch Centrum, Rotterdam

N-0310

Oslo Universitetssykehus HF, Radiumhospitalet, Oslo

N-7006

St. Olavs Hospital, Universitetssykehuset i Trondheim, Trondheim

80-952

University Clinical Center, Gdansk, Gdansk

60-569

Clin.Hosp.Med.Univ.Marcinkowski in Poznan, Poznan

Greater PL Cent.Pulmo.&Thor.Surg.Eugenia&Janusz Zeyland, Poznan

02-781

Onco.Cent. - Instit. of Maria Sklodowskiej-Curie, Warsaw

1769-001

Centro Hospitalar Lisboa Norte Hospital Pulido Valente, Lisbon

4100-180

Hospital CUF Porto, Porto

0041

Wilgers Oncology Centre, Pretoria

08035

Hospital Vall d'Hebron, Barcelona

08036

Hospital Clínic de Barcelona, Barcelona

08907

Hospital Duran i Reynals, L'Hospitalet de Llobregat

413 45

Sahlgrenska US, Göteborg, Gothenburg

581 85

Universitetssjukhuset, Linköping, Linköping

221 85

Skånes universitetssjukhus, Lund, Lund

171 76

Karolinska Univ. sjukhuset, Stockholm

751 85

Akademiska sjukhuset, Uppsala

EH4 2XU

Western General Hospital, Edinburgh

G12 0YN

Beatson West of Scotland Cancer Centre, Glasgow

LE1 5WW

Leicester Royal Infirmary, Leicester

SE1 9RT

Guy's Hospital, London

SW3 6JJ

The Royal Marsden Hospital, London

SM2 5PT

The Royal Marsden Hospital, Sutton

M23 9LT

Wythenshawe Hospital, Wythenshawe

Sponsors
All Listed Sponsors
lead

Boehringer Ingelheim

INDUSTRY