Phase II Study of Minocycline for Reducing Symptom Burden in Colorectal Patients

200 mg by mouth for the first dose, then 100 mg by mouth every 12 hours for 4 months beginning at chemotherapy initiation.

1 placebo by mouth for the first day of chemotherapy, then 1 dose every 12 hours for 4 months beginning at chemotherapy initiation.

Completion of questionnaires at baseline, 1 time each week, at each chemo cycle, at end of treatment visit, and at 6 month follow up visit.

Sensory test performed at baseline, 2 months, end of treatment visit, and at 6 month follow up visit.