Cytokine-induced Memory-like NK Cells in Patients With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS)

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

89

Participants

Timeline

Start Date

August 11, 2014

Primary Completion Date

December 28, 2021

Study Completion Date

April 4, 2022

Conditions
Leukemia, Myeloid, Acute
Interventions
DRUG

Fludarabine

DRUG

Cyclophosphamide

PROCEDURE

Leukapheresis

BIOLOGICAL

Cytokine-induced killer cells

BIOLOGICAL

IL-2

DRUG

ALT-803

PROCEDURE

Peripheral blood for correlative studies

-Screening, Day 0 prior to CIML NK infusion, Day 1, Day 3, Day 7, Day 8, Day 10, Day 14, Day 21, Day 28, Day 42, Day 60, Day 100, 6 months, 9 months, 12 months, and at disease relapse

PROCEDURE

Bone marrow for correlative studies

-Screening, Day 8, Day 14, Day 28, Between Day 42 and 60, Day 100, at disease relapse

Trial Locations (1)

63110

Washington University School of Medicine, St Louis

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

American Society of Clinical Oncology

OTHER

collaborator

American Society of Hematology

OTHER

collaborator

Gabrielle's Angel Foundation

OTHER

collaborator

The Leukemia and Lymphoma Society

OTHER

collaborator

National Cancer Institute (NCI)

NIH

collaborator

ImmunityBio, Inc.

INDUSTRY

lead

Washington University School of Medicine

OTHER

NCT01898793 - Cytokine-induced Memory-like NK Cells in Patients With Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS) | Biotech Hunter | Biotech Hunter