Transoral Surgery Followed By Low-Dose or Standard-Dose Radiation Therapy With or Without Chemotherapy in Treating Patients With HPV Positive Stage III-IVA Oropharyngeal Cancer

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

519

Participants

Timeline

Start Date

January 22, 2014

Primary Completion Date

November 30, 2020

Study Completion Date

December 31, 2026

Conditions
Human Papilloma Virus InfectionStage III Squamous Cell Carcinoma of the OropharynxStage IVA Squamous Cell Carcinoma of the OropharynxStage IVB Squamous Cell Carcinoma of the Oropharynx
Interventions
PROCEDURE

Transoral surgery

Undergo transoral surgical resection

RADIATION

intensity-modulated radiation therapy

Undergo standard-dose or low-dose IMRT

DRUG

cisplatin

Given IV

DRUG

carboplatin

Given IV

Trial Locations (58)

10065

Memorial Sloan-Kettering Cancer Center, New York

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

17109

PinnacleHealth Cancer Center-Community Campus, Harrisburg

19104

University of Pennsylvania/Abramson Cancer Center, Philadelphia

19107

Thomas Jefferson University Hospital, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

21204

Greater Baltimore Medical Center, Baltimore

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

22042

Inova Fairfax Hospital, Falls Church

22908

University of Virginia Cancer Center, Charlottesville

23454

Sentara Virginia Beach General Hospital, Virginia Beach

23507

Sentara Hospitals, Norfolk

23666

Sentara Cancer Institute at Sentara CarePlex Hospital, Hampton

27710

Duke University Medical Center, Durham

29425

Medical University of South Carolina, Charleston

30308

Emory University Hospital Midtown, Atlanta

30322

Emory University/Winship Cancer Institute, Atlanta

32803

Florida Hospital Orlando, Orlando

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33442

University of Miami Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

35233

University of Alabama at Birmingham Cancer Center, Birmingham

37232

Vanderbilt University/Ingram Cancer Center, Nashville

40536

University of Kentucky/Markey Cancer Center, Lexington

43210

Ohio State University Comprehensive Cancer Center, Columbus

44106

Case Western Reserve University, Cleveland

44195

Cleveland Clinic Foundation, Cleveland

48202

Henry Ford Hospital, Detroit

52242

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53226

Froedtert and the Medical College of Wisconsin, Milwaukee

53295

Zablocki Veterans Administration Medical Center, Milwaukee

53792

University of Wisconsin Hospital and Clinics, Madison

65804

Mercy Hospital Springfield, Springfield

66160

University of Kansas Cancer Center, Kansas City

68114

Nebraska Methodist Hospital, Omaha

68198

University of Nebraska Medical Center, Omaha

72205

University of Arkansas for Medical Sciences, Little Rock

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

77030

M D Anderson Cancer Center, Houston

80210

Porter Adventist Hospital, Denver

80304

Rocky Mountain Cancer Centers-Boulder, Boulder

80907

Penrose-Saint Francis Healthcare, Colorado Springs

Rocky Mountain Cancer Centers-Penrose, Colorado Springs

85259

Mayo Clinic in Arizona, Scottsdale

87102

University of New Mexico, Albuquerque

90095

UCLA / Jonsson Comprehensive Cancer Center, Los Angeles

91010

City of Hope Comprehensive Cancer Center, Duarte

94115

UCSF Medical Center-Mount Zion, San Francisco

94304

Stanford Cancer Institute, Palo Alto

94611

Kaiser Permanente Oakland-Broadway, Oakland

97213

Providence Portland Medical Center, Portland

97239

Oregon Health and Science University, Portland

98195

University of Washington Medical Center, Seattle

06520

Yale University, New Haven

02115

Brigham and Women's Hospital, Boston

Dana-Farber Cancer Institute, Boston

02118

Boston Medical Center, Boston

03756

Dartmouth Hitchcock Medical Center, Lebanon

10467-2490

Montefiore Medical Center - Moses Campus, The Bronx

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

ECOG-ACRIN Cancer Research Group

NETWORK