NCT01885689View on ClinicalTrials.gov

Clofarabine and Melphalan Before Donor Stem Cell Transplant in Treating Patients With Myelodysplasia, Acute Leukemia in Remission, or Chronic Myelomonocytic Leukemia

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

72

Participants

Timeline

Start Date

February 10, 2014

Primary Completion Date

December 27, 2019

Study Completion Date

October 8, 2025

Conditions
Adult Acute Lymphoblastic Leukemia in RemissionAcute Myeloid Leukemia Arising From Previous Myelodysplastic SyndromeAdult Acute Myeloid Leukemia in RemissionMyelodysplastic SyndromeSecondary Myelodysplastic SyndromeChronic Myelomonocytic LeukemiaTherapy-Related Myelodysplastic Syndrome
Interventions
DRUG

clofarabine

Given IV

DRUG

melphalan

Given IV

PROCEDURE

allogeneic hematopoietic stem cell transplantation

Undergo allogeneic hematopoietic stem cell transplant

DRUG

tacrolimus

Given IV or PO

DRUG

sirolimus

Given PO

OTHER

Pharmacological Study

Correlative studies

Trial Locations (1)

91010

City of Hope Medical Center, Duarte

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

City of Hope Medical Center

OTHER