422
Participants
Start Date
January 20, 2014
Primary Completion Date
December 18, 2015
Study Completion Date
December 18, 2015
Tofacitinib 5 mg BID
Tofacitinib orally (po) 1 tablet of 5 mg and placebo po 1 tablet BID x 12 months Placebo injections subcu every 2 weeks x 12 months
Tofacitinib 10 mg BID
Tofacitinib po 2 tablets of 5 mg BID x 12 months Placebo injections subcu every 2 weeks x 12 months
Adalimumab
Placebo po 2 tablets BIDx 12 months Adalimumab 40 mg subcu injections every 2 weeks x 12 months
Placebo
Placebo po 2 tablets BIDx 3 months followed by tofacitinib po 1 tablet of 5 mg and placebo po 1 tablet BID x 9 months Placebo injections every 2 weeks x 12 months
Placebo
Placebo po 2 tablets BIDx 3 months followed by tofacitinib po 2 tablets (5 mg) BID x 9 months Placebo injections every 2 weeks x 12 months
Revita Reumatologiai Rendelo, Budapest
Qualiclinic Kft., Budapest
Magyar Honvedseg Egeszsegugyi Kozpont,Reumatologiai osztaly, Budapest
Hopital Erasme - Clinique Universitaire de Bruxelles, Brussels
"UMHAT Sv. Ivan Rilski EAD", Sofia
University Hospital Leuven, Department of Rheumatology, Leuven
St. Vincent's Hospital (Melbourne), Fitzroy
Emeritus Research Pty Ltd, Malvern East
Monash Health, Monash Medical Centre, Clayton
Pharmacy Clinical Trials, Clayton
"MHATPlovdiv AD", Plovdiv
"MHAT Kaspela EOOD", Plovdiv
Pacific Private Clinic, Southport
Rheumatology Research Unit, Maroochydore
"UMHAT Dr. G. Stranski EAD", Pleven
"MC New rehabilitation center EOOD, Rheumatology Cabinet", Stara Zagora
Csolnoky Ferenc Korhaz, Radiologiai Osztaly X-Ray Only, Veszprém
Csolnoky Ferenc Korhaz, Reumatologiai Osztaly, Veszprém
Charite Universitaetsmedizin Berlin, Berlin
Klinische Forschung Berlin-Mitte GmbH, Berlin
Taipei Veterans General Hospital, Taipei
Rheumapraxis Steglitz, Berlin
Complexo Hospitalario Universitario A Coruna, A Coruña
Hospital Clinico de Santiago, Santiago de Compostela
Altoona Center for Clinical Research, Duncansville
Klinische Forschung Schwerin GmbH, Schwerin
Klein & Associates, M.D., P.A., Hagerstown
Low Country Rheumatology, PA, Charleston
Investigacion y Biomedicina de Chihuahua SC, Chihuahua City
Millennium Research, Ormond Beach
Arthritis Center, Inc., Palm Harbor
Rheumatology Associates, PC, Birmingham
Rheumatology Associates of North Alabama, PC, Huntsville
Hospital Universitario Marques de Valdecilla, Santander
Chung Shan Medical University Hospital, Taichung
Hospital Infanta Luisa, Seville
Paramount Medical Research & Consulting, LLC, Middleburg Heights
Centro Integral en Reumatologia SA de CV, Guadalajara
Hospital Universitario y Politecnico La Fe, Valencia
University Hospital of Cologne, Cologne
St. Paul Rheumatology, PA, Eagan
X-MEDICA s.r.o (radiology only), Brno
Buddhist Dalin Tzu Chi General Hospital, Chiayi City
Stavovska s.r.o. (pharmacy only), Brno
Physician Research Collaboration, LLC, Lincoln
Medical Plus s.r.o. Lekarna Hradebni s. r.o, Uherské Hradiště
Vesalion s.r.o., Ostrava
Pioneer Research Solutions, Inc., Houston
Centro de Investigacion de Tratamientos Innovadores de Sinaloa, S.C., Culiacán
Laboratorios de Analisis Clinicos CEMSI, Culiacán
Sanatorio CEMSI Chapultepec (For Emergencies Only), Culiacán
Hospital General de Culiacán Dr. Bernardo J. Gastélum, Culiacán
Chang Gung Medical Foundation-Kaohsiung Branch, Kaohsiung City
Drug Shipment/Storage: Huntsman Cancer Hospital at the University of Utah, Salt Lake City
University of Utah Hospital & Clinics, Salt Lake City
Arizona Arthritis & Rheumatology Associates, P.C., Glendale
Centre Hospitalier Sud-Francilien - Secretariat de Rhumatologie, Corbeil-Essonnes
Medvin Clinical Research, Covina
San Diego Arthritis Medical Clinic, San Diego
Desert Medical Advances, Palm Desert
Advances In Medicine (X-Rays), Rancho Mirage
Instituto Medico Panamericano, S.A. de C.V. (For Emergencies Only), Mérida
Unidad Reumatologica Las Americas, S.C.P., Mérida
Centro de Investigacion Clinica Pensiones, Mérida
Centro Multidisciplinario para el Desarrollo Especializado de la Investigacion Clinica en Yucatan, Mérida
Hospital Star Medica Merida (For Emergencies Only), Mérida
HOSPITAL STAR MEDICA S.A DE C.V- (emergencies only), Mérida
Dynacare Laboratories (Specimen processing for shipment), Seattle
Investigational Drug Service Pharmacy, Swedish Medical Center., Seattle
Seattle Rheumatology Associates, Seattle
Swedish Medical Center, Seattle
State Budgetary Institution of Healthcare of Moscow City Clinical Hospital, Moscow
State Healthcare Institution of Yaroslavl Region Clinical Emergency Hospital n.a. N.V. Solovyev, Yaroslavl
State Institution of Healthcare of Yaroslavl Region, Yaroslavl
Regional State Budgetary Healthcare Institution of Karelia Republic, Petrozavodsk
"State Institution of Healthcare Regional Clinical Hospital", Saratov
"OOO City Neurological Centre Sibneiromed", Novosibirsk
"Limited Liability Company Consultative Diagnostic Rheumatology Center Healthy Joints", Novosibirsk
State Budget Educational Institution of Highest Professional Education, Tomsk
Clinical Pharmacology Study Group, Worcester
Dartmouth-Hitchcock Medical Center (DHMC), Lebanon
Rheumatology Research Associates, Edmonton
K. Papp Clinical Research, Waterloo
West Island Rheumatology Research Associates, Pointe-Claire
Revmacentrum MUDr. Mostera, s.r.o., Brno
Revmatologicky Ustav - Lekarna (pharmacy only), Prague
Revmatologicky ustav - Lekarna, Prague
Revmatologicky ustav, Prague
Revmatologicka ambulance, Prague
MEDIGAP, s.r.o. (radiology only), Praha 1 - Nove Mesto
MEDIGAP, s.r.o, Praha 1- Nove Mesto
Lekarna Na Lidicke (Pharmacy only), Brno
Revmatologie s.r.o., Brno
Cliditer, S. A. de C. V, Mexico City
"Niepubliczny Zaklad Opieki Zdrowotnej Przychodnia Chirurgiczna dla Dzieci PriamaMed Sp.P.,", Bialystok
ZDROWIE OSTEO-MEDIC s.c. L. i A. Racewicz, A. i J. Supronik, Bialystok
ClinicMed Badurski i wspolnicy Spolka Jawna, Bialystok
Szpital Uniwersytecki nr 2 im. dr Jana Biziela w Bydgoszczy,, Bydgoszcz
Centrum Kliniczno-Badawcze J.Brzezicki, B.Gornikiewicz-Brzezicka Lekarze Spolka Partnerska, Elblag
Centrum Radiologii for X-Ray only, Elblag
NZOZ Centrum Reumatologiczne Indywidualna Specjalistyczna Praktyka Lekarska Lek. Med. Barbara Bazela, Elblag
"Przychodnia Specjalistyczna Lekarskiej Spoldzielni Pracy Medica", Grodzisk Mazowiecki
Zespol Poradni Specjalistycznych Reumed Filia Onyksowa, Lublin
NZOZ Lecznica MAK-MED S.C., Nadarzyn
Prywatna Praktyka Lekarska Prof. UM dr hab. Pawel Hrycaj, Poznan
NZOZ Nasz Lekarz Praktyka Grupowa Lekarzy Rodzinnych z Przychodnia Specjalistyczna w Toruniu, Torun
Medica Pro Familia Sp. z o.o. S.K.A., Warsaw
Rheuma Medicus Zaklad Opieki Zdrowotnej, Warsaw
Reumatika Centrum Reumatologii, Warsaw
Klinika Ambroziak Estederm Sp. z o.o. ,S.K.A, Warsaw
Synexus Polska Sp. z o.o. Oddz. we Wroclawiu, Wroclaw
ROMJAN s.r.o., Reumatologicka ambulancia, Bratislava
MEDMAN s.r.o. - reumatologicka ambulancia, Martin
Nestatna reumatologicka ambulancia, Bratislava
Reumex s.r.o, Rimavská Sobota
Corporació Sanitaria Parc Tauli, Sabadell
Barking Havering and Redbridge University Hospital NHS Trust-King George Hospital, Goodmayes
Barking, Havering and Redbridge University Hospitals NHS Trust, Romford
The Dudley Group NHS Foundation Trust, Dudley
Bradford Teaching Hospitals NHS Foundation Trust, Bradford
Bradford Royal Infirmary, BTHFT, Bradford
Wirral University Teaching Hospital NHS Foundation Trust, Upton
York Teaching Hospital NHS Foundation Trust, York
Lead Sponsor
Pfizer
INDUSTRY