34
Participants
Start Date
June 30, 2013
Primary Completion Date
December 31, 2015
Study Completion Date
April 30, 2017
Topiramate
Topiramate will be initiated at a dose of 25 mg (taken orally once daily in the evening), escalated to 50 mg (taken orally once daily in the evening) after 1 week, and escalated to 75 mg (taken orally 25 mg in the morning and 50 mg in the evening) after 2 weeks. Patients who do not tolerate dose escalation will be reduced to the highest tolerated dose for the remainder of the trial.
Placebo
Placebo will be taken orally once daily in the evening for the first two weeks, and orally twice daily (AM and PM) for the remainder of the study.
University of Minnesota, Minneapolis
University of Minnesota
OTHER