Pharmacokinetic and Safety Trial to Determine the Appropriate Dose for Pediatric Patients With Multidrug Resistant Tuberculosis

PHASE1CompletedINTERVENTIONAL
Enrollment

37

Participants

Timeline

Start Date

June 14, 2013

Primary Completion Date

December 10, 2017

Study Completion Date

December 28, 2017

Conditions
Multidrug Resistant TuberculosisPediatric
Interventions
DRUG

100 mg Delamanid

100 mg Delamanid BID for 10 days

DRUG

50 mg Delamanid

50 mg Delamanid BID for 10 days

DRUG

25 mg Pediatric Formulation Delamanid

25 mg Pediatric Formulation Delamanid BID for 10 days

DRUG

10 mg Delamanid Pediatric Formulation

Patients \> 10 kg will receive DPF 10 mg BID for 10 days

DRUG

5 mg Delamanid Pediatric Formulation

"Patients \> 8 kg and ≤ 10 kg will receive DPF 5 mg BID for 10 days~Patients ≤ 8 kg will receive DPF 5 mg QD for 10 days"

DRUG

Optimized Background Regimen

Selection and administration of the treatment medications (i.e. OBRs) will be based on WHO's Guidelines for the programmatic management of drug-resistant TB, in conjunction with national TB program guidelines in each country

Trial Locations (2)

4114

De La Salle Health Sciences Institute, Dasmariñas

Unknown

Brooklyn Chest Hospital, Ysterplaat

All Listed Sponsors
lead

Otsuka Pharmaceutical Development & Commercialization, Inc.

INDUSTRY

NCT01856634 - Pharmacokinetic and Safety Trial to Determine the Appropriate Dose for Pediatric Patients With Multidrug Resistant Tuberculosis | Biotech Hunter | Biotech Hunter