LUX-Head&Neck 3: Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer After Platinum Based Chemotherapy

PHASE3CompletedINTERVENTIONAL
Enrollment

340

Participants

Timeline

Start Date

June 7, 2013

Primary Completion Date

August 22, 2018

Study Completion Date

October 2, 2024

Conditions
Head and Neck Neoplasms
Interventions
DRUG

methotrexate

intravenous bolus injection, once weekly

DRUG

afatinib

oral intake, once daily

Trial Locations (53)

100

National Taiwan University Hospital, Taipei

204

Keelung Chang Gung Memorial Lover's Lake Branch, Keelung

407

Taichung Veterans General Hospital, Taichung

1102

St. Luke's Medical Center, Quezon City

6000

Perpetual Succour Hospital (Cebu), Cebu City

10408

National Cancer Center, Goyang

11490

Tri-Service General Hospital, Taipei

11796

National Cancer Institute, Cairo University, Cairo

21131

Alexandria Clinical Research Center, Alexandria

35516

Mansoura University Faculty of Medicine, Dakahlia

40002

Srinagarind Hospital, Muang

50200

Maharaj Nakom Chiangmai Hospital, Chiang Mai

65000

Naresuan University Hospital, Phitsanulok

90110

Songklanagarind Hospital, Songkhla

100020

Beijing Chao-Yang Hospital, Beijing

100021

Cancer Hospital of Chinese Academy of Medical Science, Beijing

100037

Navy General Hospital, Beijing

100730

Peking Union Medical College Hospital, Beijing

130021

The First Hospital of Jilin University, Changchun

150081

Harbin Medical University Cancer Hospital, Harbin

200001

Renji Hospital Shanghai Jiaotong Univesrity School of Medicine, Shanghai

200003

Shanghai Changzheng Hospital, Shanghai

200011

Shanghai Ninth People's Hospital, Shanghai

200032

Fudan University Shanghai Cancer Center, Shanghai

200125

Shanghai Ninth People's Hospital, Shanghai

208005

J K Cancer Institute, Kanpur

210002

the 81th Hospital of PLA, Nanjing

226003

King George Medical University, Lucknow

233004

The First Affiliated Hospital Of Bengbu Medical College, Bengbu

310022

Zhejiang Cancer Hospital, Hangzhou

313002

Geetanjali Medical College and Hospital, Jaipur

334001

Acharya Tulsi Regional Cancer Treatment & Research Institute, Bikaner

411001

Ruby Hall Clinic, Pune

411013

Noble Hospital Pvt Ltd, Pune

422002

Shatabdi Hospital, Nashik, Nashik

430022

Wuhan Union Hospital, Wuhan

430030

Tongji Hospital, Tongji University, Wuhan

440009

Government Medical College & Hospital, Nagpur

444606

Sujan Surgical Cancer Hospital, Amravati

500004

M N J Institute of Oncology and Regional Cancer Centre, Hyderabad

510060

Sun Yat-Sen University Cancer Center, Guangzhou

560086

Pristine Hospital, Bengaluru

600003

Rajiv Gandhi Government General Hospital, Chennai

610041

Sichuan Cancer Hospital, Chengdu

610042

West China Hospital, Chengdu

700053

B. P .Poddar Hospital & Medical Research Ltd., Kolkata, West Bengal

999077

Pamela Youde Nethersole Eastern Hospital, Hong Kong

Queen Mary Hospital, Hong Kong

Prince of Wales Hospital, Shatin

120-752

Severance Hospital, Seoul

135-710

Samsung Medical Center, Seoul

137-701

The Catholic University of Korea, Seoul St.Mary's Hospital, Seoul

138-736

Asan Medical Center, Seoul

Sponsors
All Listed Sponsors
lead

Boehringer Ingelheim

INDUSTRY