Photodynamic Therapy for the Treatment of Chronic Rhinosinusitis

A 0.03% solution of methylene blue is irrigated into the involved paranasal sinus followed by placement of a saline filled balloon with a center light diffusing fiber optic. This is illuminated at 150 mW/cm2 power density for 8 minutes. This is repeated for each involved sinus.

The active comparator arm will receive saline irrigation via syringe that is administered using a sinus irrigation catheter under endoscopic control.