481
Participants
Start Date
July 17, 2013
Primary Completion Date
March 6, 2024
Study Completion Date
March 6, 2024
Afatinib
Patients received a daily dose of 40 milligrams (mg) of afatinib (Giotrif®), in the form of film-coated tablet over a 28 day cycle. Afatinib was taken orally with 250 milliliters (mL) of water at the same time of the day and without eating anything for at least 3 hours. Patients continued on treatment for as long as there was no disease progression or no other trial withdrawal criteria. The dose was reduced to 30 mg or 20 mg once daily when the initial dose was not tolerated by the patient.
Koranyi National Institute For Pulmonolgy, Budapest
Klinik Penzing SMZ Baumgartner Hoehe, Vienna
The Prince of Wales Hospital, Randwick
Sunshine Hospital, AT Albans
Ordensklinikum Linz GmbH - Barmherzige Schwestern, Linz
Klinikum Wels - Grieskirchen GmbH, Wels
St John of God Murdoch, Murdoch
Institute of Chest Diseases Csongrad County,Dpt. Pulmonology, Deszk
Fejer County Saint George University Teaching Hospital, Székesfehérvár
Medical University of Graz State Hospital - University Hospital Graz, Graz
Pulmonology Institute of Veszprem County, Farkasgyepu, Farkasgyepü
Azienda Sanitaria Ospedale S. Luigi Gonzaga, Orbassano (TO)
AO Città della Salute e Scienza, Torino
"Chest Hospital of Athens Sotiria", Athens
Hospital Universitario Reina Sofía, Córdoba
"General Oncology Hospital Agioi Anargyri", Nea Kifissia
Hospital A Coruña, A Coruña
Azienda Ospedaliera Santi Antonio e Biagio e Cesare Arrigo, Alessandria
Hospital Clínico de Santiago, Santiago de Compostela
Azienda Ospedaliera San Martino, Genova
Hospital Universitario Virgen de las Nieves, Granada
Metropolitan Hospital, Oncology Clinic, N. Faliro
A.O. San Gerardo di Monza, Monza (MI)
IRCCS Fondazione Ospedale Maggiore, Milan
IRCCS San Raffaele, Milan
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
Istituto Europeo di Oncologia, Milan
ASST Grande Ospedale Metropolitano Niguarda, Milan
A. O. Ospedali Riuniti di Bergamo, Bergamo
A.O. Spedali Civili di Brescia, Brescia
Hospital La Princesa, Madrid
Hospital General Universitario Gregorio Marañón, Madrid
Hospital Ramón y Cajal, Madrid
Fundación Jiménez Díaz, Madrid
Hospital Clínico San Carlos, Madrid
Hospital Universitario 12 de Octubre, Madrid
Hospital La Paz, Madrid
A.O.U. Maggiore della Carita', Novara
Hospital Puerta de Hierro, Majadahonda (Madrid)
Hospital Regional Universitario de Málaga, Málaga
Hospital Virgen de la Victoria, Málaga
Complejo Hospitalario de Navarra, Pamplona
Ospedale S. Maria di Ca' Foncello Azienda ULSS9 TREVISO, Treviso
Hospital Central de Asturias, Oviedo
Centro di riferimento Oncologico, Aviano (PN)
A. O. S. Maria della Misericordia, Udine
Istituto Oncologico Veneto IRCCS, Padua
Ospedale Policlinico G.B. Rossi (Borgo Roma) di Verona, Verona
Hospital de Canarias, La Laguna - Tenerife
Ospedale Centrale di Bolzano, Bolzano
Osp. S. Maria della Scaletta, Imola
Policlinico S. Orsola Malpighi, Bologna
Hospital Virgen del Rocío, Seville
Università di Modena e Reggio Emilia, Modena
Azienda Ospedaliera di Parma, Parma
Meir Medical Center, Kfar Saba
Hospital Politècnic La Fe, Valencia
Hospital Clínico de Valencia, Valencia
Hospital General Universitario de Valencia, Valencia
Istituto Scientifico Romagnolo, Meldola (FC)
Ospedale S. Maria delle Croci, Ravenna
Hospital Universitario de Cruces, Barakaldo (Bilbao)
Hospital Clínico Universitario Lozano Blesa, Zaragoza
Hospital Miguel Servet, Zaragoza
Azienda Ospedaliera Careggi, Florence
The Chaim Sheba Medical Center Tel HaShomer, Tel Litwinsky
Osp. Campo di Marte, Lucca
Azienda Ospedaliera Universitaria Pisana, Pisa
"General Hospital of Thessaloniki G. Papanikolaou", Thessaloniki
Az. Ospedaliere Umberto I di Ancona, Ancona
Sourasky Medical Center, Tel Aviv
Istituto Tumori Giovanni Paolo II, Bari
Azienda Ospedaliera Vito Fazzi, Lecce
Istituto Nazionale IRCCS Tumori Fondazione Pascale, Napoli
Osp. dei Colli Monaldi-Cotugno, Napoli
A. O. Giuseppe Moscati, Avellino
Soroka Univ. Medical Center, Beersheba
Irccs Crob, Rionero in Vulture (PZ)
"A.O. Univ. Policlinico Paolo Giaccone", Palermo
Casa di Cura La Maddalena, Palermo
Moscow City Oncology Dispensary, Moscow, Moscow
"FSBI N.N Blokhin Med.Res.Cent.Onc.MoH of RF", Moscow
St. Petersburg GUZ City Clinical Oncology Dispensary, Saint Petersburg
"FSBI N.N. Petrov National Medical Research Center of Oncology of MoH of RF", Saint Petersburg
"St.Auton.Heal.Inst.Rep.Clin.Onc.Disp.of MoH of Rep. Tatarstan", Kazan'
Rabin Medical Center Beilinson, Petah Tikva
University Hospital Brno, Brno
Hospital Hradec Kralove, Hradec Králové
University Hospital Ostrava, Ostrava
University Hospital Plzen, Plzen-Bory, Pilsen
Ospedale S.Maria della Misericordia, AO di Perugia, Perugia
Università Campus Bio-Medico - ROMA, Roma
Istittuo Nazionale Tumori Regina Elena - IRCCS, Roma
A.O. San Camillo Forlanini, Roma
Poli Univ A. Gemelli, Roma
Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza, Roma
"Azienda Ospedaliera Santo Maria", Terni
Oncology Center na F. Lukaszczyka, Bydgoszcz
University Clinical Center, Gdansk, Gdansk
Provincial Specialist M. Kopernik Hospital, Lodz
MS Clinsearch, Private Practice, Lublin
MED POLONIA SP Z O O, Clinical Trials Department,Poznan, Poznan
Oncology Center-Maria Sklodowska-Curie Institute, Warsaw
ULS de Coimbra, E.P.E., Coimbra
IPO Lisboa Francisco Gentil, EPE, Lisbon
Centro Hospitalar Lisboa Norte Hospital Pulido Valente, Lisbon
IPO Porto Francisco Gentil, EPE, Porto
ULS de Gaia/Espinho, EPE, Vila Nova de Gaia
Clinical Oncology Center, Omsk
Hospital General Universitario de Alicante, Alicante
Hospital Germans Trias i Pujol, Badalona
Hospital del Mar, Barcelona
Hospital Vall d'Hebron, Barcelona
Hospital Clínic de Barcelona, Barcelona
Hospital Santa Creu i Sant Pau, Barcelona
Hospital Duran i Reynals, L'Hospitalet de Llobregat
Hospital Son Espases, Palma de Mallorca
Hospital de Son Llàtzer, Palma de Mallorca
Lead Sponsor
Boehringer Ingelheim
INDUSTRY