A Study of MEK162 vs. Physician's Choice Chemotherapy in Patients With Low-grade Serous Ovarian, Fallopian Tube or Peritoneal Cancer

PHASE3TerminatedINTERVENTIONAL
Enrollment

341

Participants

Timeline

Start Date

June 27, 2013

Primary Completion Date

January 20, 2016

Study Completion Date

August 23, 2022

Conditions
Low-grade Serous Ovarian CancerLow-grade Serous Fallopian Tube CancerLow-grade Serous Peritoneal Cancer
Interventions
DRUG

MEK162, MEK inhibitor; oral

multiple dose, single schedule

DRUG

Physician's choice chemotherapy

"Patients will receive one of the following chemotherapies as determined by the physician:~* Liposomal doxorubicin, anthracycline antibiotic; intravenous (multiple dose, single schedule)~* Paclitaxel, mitotic inhibitor; intravenous (multiple dose, single schedule)~* Topotecan, topoisomerase 1 inhibitor; intravenous (multiple dose, single schedule)"

Trial Locations (226)

1062

Magyar Honvedseg Egeszsegugyi Kozpont, Onkologiai Osztaly, Budapest

Magyar Honvedseg Egeszsegugyi Kozpont, Budapest

1088

Semmelweis Egyetem AOK Szemeszeti Klinika, Budapest

1122

Orszagos Onkologiai Intezet Kozponti Aneszteziologiai es Intenzivterapias Osztaly, Budapest

Orszagos Onkologiai Intezet, Nogyogyaszati Osztaly, Budapest

Orszagos Onkologiai Intezet, Budapest

1134

Magyar Honvedseg Egeszsegugyi Kozpont, Budapest

1200

Cliniques Universitaires Saint-Luc, Brussels

2076

Dr Anil Arora, Wahroonga

Sydney Adventist Hospital, Wahroonga

2100

Ojenklinikken 2061, København Ø

Radiologisk Afdeling 2023, København Ø

Region Hovedstadens Apotek, København Ø

Rigshospitalet, København Ø

2145

Westmead Hospital, Westmead

2610

Sint-Augustinus, Wilrijk

3000

University Hospital Leuven, Leuven

3021

Sunshine Hospital, St Albans

4000

CHR de la Citadelle, Liège

4101

Mater Misericordiae Health Services Brisbane Limited, South Brisbane

5000

Adelaide Cardiology, Adelaide

Adelaide Eye and Retina Centre, Adelaide

Royal Adelaide Hospital, Adelaide

Clinique et Maternite Sainte-Elisabeth Namur, Namur

5065

Burnside War Memorial Hospital, Toorak Gardens

5067

Thomas and Delaney Optometrists, Norwood

6009

Sir Charles Gairdner Hospital, Nedlands

6800

Centre Hospitalier de l'ardenne, Libramont

Private practice Ophthalmology, Libramont

9000

Ghent University Hospital, Ghent

University Hospital Gent, Ghent

Aalborg Sygehus Apotek, Aalborg

Aalborg University Hospital, Aalborg

9023

Euromedic Diagnostics Magyarorszag Kft., Győr

9024

Petz Aladar Korhaz Kardiologiai Osztaly, Győr

Petz Aladar Korhaz Szemeszeti Osztaly, Győr

10022

Memorial Sloan Kettering Cancer Center, New York

10461

Montefiore Medical Center - Einstein Center for Cancer Care, The Bronx

Montefiore Medical Center, The Bronx

10467

Montefiore Medical Center - Centennial Women's Health, The Bronx

Montefiore Medical Center, Green Medical Arts Pavilion, The Bronx

13008

Centre Paradis Monticelli, Marseille

13273

Institut Paoli Calmettes - Departement d'Oncologie Medicale, Marseille

13353

Charité Universitaetsmedizin Berlin, Berlin

14004

Hospital Universitario Reina Sofía/ Provincial, Córdoba

Cardiology at Consulta de Cardiologia, Córdoba

14012

Centro Medico Sanitas Ressalta, Córdoba

Instituto de Oftalmologia y Hospital La Arruzafa, Córdoba

Radiology at Centro Medico Sanitas Ressalta, Córdoba

15213

Magee-Womens Hospital of UPMC, Pittsburgh

University of Pittsburgh Medical Center, Pittsburgh

17475

Frauenheilkunde und Geburtshilfe, Greifswald

19111

Fox Chase Cancer Center, Philadelphia

Jeanes Hospital, Philadelphia

20014

Hospital Universitario Donostia, Donostia / San Sebastian

20089

Istituto Clinico Humanitas, Rozzano

20132

Ospedale San Raffaele - Unita Operativa di Oculistica, Milan

20133

Fondazione IRCCS Istituto Nazionale dei Tumori - SC Oncologia Ginecologica, Milan

20141

Istituto Europeo Oncologico, Milan

20270

Centro de Salud Anoeta, Anoeta

21201

University of Maryland Greenebaum Cancer Center, Baltimore

22190

Centre Investigateur CARIO - HPCA, Plérin

22903

University of Virginia, Charlottesville

24105

Universitätsklinikum Schleswig-Holstein, Kiel

25000

CHU Jean Minjoz, Besançon

25123

Spedali Civili di Brescia - Struttura Complessa Clinicizzata - U.O.di Oculistica, Brescia

25125

Spedali Civili Di Brescia, Brescia

28034

Hospital Ramón Y Cajal, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

30912

Georgia Regents University Cancer Center, Augusta

32751

Eye Physicians of Central Florida, Maitland

32803

Florida Hospital, Orlando

32804

Florida Hospital Cancer Institute, Orlando

32835

Eye Physicians of Central, Orlando

33081

Centro di Riferimento Oncologico - Struttura Operativa Complessa (SOC)- Oncologia Medica C, Aviano

Azienda Opsedaliera S. Maria Degli Angeli Pordenone-Dipartimento di Chirurgia Specialistica -, Pordenone

33401

Florida Cancer Specialists, West Palm Beach

33414

Florida Cancer Specialists, Wellington

34125

Klinik fur Frauenheilkunde und Geburtshilfe, Kassel

34298

Institut Regional du Cancer Montpellier, Montpellier

34980

Centre d'Ophtalmologie du LEZ Centre Medical Les Roques, Montferrier S/lez

40138

SSD Oncologia Medica Addarii-Zamagni - Policlinico S. Orsola-Malpighi, Bologna

Struttura Complessa di Oftalmologia Policlinico S. Orsola-Malpighi, Bologna

41009

Hospital Universitario Virgen Macarena, Seville

43026

OSU Gynecologic Oncology at Mill Run, Hilliard

43210

James Cancer Hospital & Solove Research Institute, Columbus

OSU Wexner Medical Center, Columbus

43212

Stefanie Spielman Comprehensive Breast Cancer, Columbus

44000

Cabinet Liberal du Dr Xavier Zanlonghi, Nantes

Clinique Sourdille, Nantes

44111

Fairview Hospital Moll Pavilion Cancer Center, Cleveland

44124

Hillcrest Hospital, Mayfield Heights

44195

Cleveland Clinic Taussig Cancer Center, Cleveland

Cleveland Clinic-Main Campus, Cleveland

44277

L'Hopital Prive du Confluent SAS, Nantes

44805

Institut de Cancerologie de I'Ouest - Rene Gauducheau, Saint-Herblain

45004

Hospital Virgen de la Salud, Toledo

45136

Kliniken Essen-Mitte, Essen

45219

University of Cincinnati Medical Center, Cincinnati

University of Cincinnati Physicians Company, West Chester

46009

Fundacion IVO-Instituto Valenciano de Oncologia, Valencia

46026

Ophthalmology at Hospital Universitari i Politecnic La Fe de Valencia, Valencia

46260

St. Vincent Cancer Care, Indianapolis

St. Vincent Gynecologic Oncology, Indianapolis

St. Vincent Gynecology Oncology, Indianapolis

St. Vincent Hospital and Health Care Center, Inc., Indianapolis

46290

Associated Vitreoretinal and Uveitis Consultants, Indianapolis

48018

Ospedale Civile degli Infermi - Servizio di Oculistica, Faenza

Ospedale Civile degli Infermi - Unita Operativa di Oncologia Medica, Faenza

48022

Ospedale Umberto I - Unita Operativa di Oncologia, Lugo

48121

Ospedale Santa Maria delle Croci - Oculistica, Ravenna

Ospedale Santa Maria delle Croci - Unita Operativa di Oncologia, Ravenna

48201

Karmanos Cancer Institute, Detroit

Kresge Eye Institute, Detroit

48334

Karmanos Cancer Institute, Farmington Hills

52242

University of Iowa Hospitals and Clinics, Iowa City

53127

Universitätsklinikum Bonn, Bonn

59000

Centre Oscar Lambret, Lille

Hopital Prive La Louviere, Lille

59101

Billings Clinic, Billings

60637

University of Chicago Medical Center, Chicago

63110

Barnes-Jewish Hospital, St Louis

Center for Advanced Medicine, St Louis

Center For Clinical Studies, St Louis

Washington University, St Louis

69003

Hopital Edouard Herriot, Lyon

69120

NCT Nationales Centrum für Tumorerkrankungen Heidelberg, Heidelberg

69373

Centre Leon Berard, Lyon

70852

Fakultni Nemocnice Ostrava, Ostrava - Poruba

72076

Universitaets-Brustzentrum, Tübingen

73104

Dean McGee Eye Institute, Oklahoma City

Stephenson Cancer Center(clinic location), Oklahoma City

Stephenson Cancer Center, Oklahoma City

75012

Centre d'Investigations Cliniques 1423, Paris

75235

Parkland Health and Hospital System, Dallas

UT Southwestern Medical Center-Zale Lipshy University Hospital, Dallas

75390

UT Southwestern Medical Center-Clements University Hospital, Dallas

UT Southwestern Medical Center, Dallas

75908

Hopital Europeen Georges Pompidou, Paris

77030

University of Texas MD Anderson Cancer Center, Houston

79106

Universitaetsklinik Freiburg, Freiburg im Breisgau

80045

Rocky Mountain Lions Eye Institute, Aurora

University of Colorado Cancer Center, Aurora

University of Colorado Denver, University of Colorado Cancer Center, Aurora

80131

Azienda Ospedaliera Vincenzo Monaldi di Napoli - U.O.C. di Oculistica, Napoli

"Istituto Nazionale Tumori di Napoli, G.Pascale , Oncologia Medica, Dipartimento Uro-Ginecologico", Napoli

Universita degli Studi Federico II di Napoli Dipartimento di Neuroscienze Scienze, Napoli

Universita degli Studi Federico II di Napoli Oncologia Medica, Napoli

81675

Klinikum rechts der Isar, Munich

85004

University of Arizona Cancer Center, Phoenix

85020

Associated Retina Consultants, Ltd., Phoenix

85258

Oncology Research Associates, PLLC d/b/a Pinnacle Oncology Hematology, Scottsdale

87106

University of New Mexico Cancer Center, Albuquerque

87109

Eye Associates of New Mexico, Albuquerque

89075

Universitätsfrauenklinik Ulm, Ulm

90033

Keck Hospital of USC, Los Angeles

LAC & USC Medical Center, Los Angeles

USC Healthcare Consultation Center 1, Los Angeles

USC Healthcare Consultation Center 2, Los Angeles

USC Norris Comprehensive Cancer Center, Los Angeles

USC/Norris Comprehensive Cancer Center, Los Angeles

90095

Admin.Office/Study Supplies Mailing Address: UCLA Medicine Hematology-Oncology, Los Angeles

Doris Stein Research Center Building, Los Angeles

University of California Los Angeles, Hematology-Oncology Clinic, Los Angeles

90404

UCLA Hematology/Oncology Clinic - Santa Monica, Santa Monica

91355

UCLA Hematology Oncology Clinic Santa Clarita, Valencia

91361

UCLA Hematology - Oncology Clinic - Westlake Village, Westlake Village

92663

Gynecologic Oncology Associates, Newport Beach

92868

University of California, Irvine/UC Irvine Health, Orange

94805

Institut Gustave Roussy, Villejuif

95216

Azienda Ospedaliera Cannizzaro, Catania

06510

Smilow Cancer Hospital at Yale-New Haven, New Haven

33612-9497

H. Lee Moffitt Cancer Center and Research Institute, Tampa

02114

Massachusetts General Hospital, Boston

Ophthalmic Consultants of Boston (OCB), Boston

A-6020

Innsbruck Medical University, Innsbruck

T2N 4N2

Tom Baker Cancer Centre, Calgary

V5Z 4E6

British Columbia Cancer Agency - Vancouver Centre, Vancouver

R2H 2A6

CancerCare Manitoba, Winnipeg

L8V 5C2

Juravinski Cancer Center, Department of Oncology, Hamilton

M5G 2M9

Princess Margaret Cancer Centre, Toronto

H2L 4M1

Centre Hospitalier de l'Universite de Montreal (Chum) - Hopital Notre-Dame, Montreal

H3T 1E2

Jewish General Hospital, Montreal

500 05

Teaching Hospital Hradec Kralove, Hradec Králové

775 20

Fakultni nemocnice Olomouc, Olomouc

708 52

Fakultni nemocnice Ostrava, Ostrava - Poruba

Fakultni nemocnice Ostrava, Ostrava-Poruba

120 00

General University Hospital in Prague, Prague

128 08

General University Hospital in Prague, Prague

02730

Herlev Hospital Onkologisk AFD, Herlev

FI-33251

Tampere University Hospital, Tampere

01307

Uni Carl Gustav Carus, Dresden

Unknown

St James's Hospital, Dublin

00144

Istituto Nazionale Tumori Regina Elena - Oncologia Medica A, Roma

00155

Policlinico Umberto I - Università Sapienza, Roma

00189

Azienda Ospedaliera Sant' Andrea - Unita Operativa Semplice di Patologia Vitreo-Retinica, Roma

00161

Dipartimento Organi di Senso, Roma

00168

Dipartimento di Scienze Chirurgiche per le Patologie della Testa e del Collo - UOC di Oculistica, Roma

Policlinico Agostino Gemelli, Roma

1150 AZ

Academic Medical Center (AMC), Amsterdam

9713 GZ

University Medical Center Groningen, Medical Oncology, Groningen

6229 HX

Maastricht University Medical Centre, Maastricht

0264

Aleris, Oslo

0379

Avd. for gynekologisk kreft, Radiumhospitalet, Oslo

0450

Oslo Universitetssykehus HF, Oslo

04-141

Centralny Szpital Kliniczny MON, Warsaw

08908

Hospital Duran i Reynals, L'Hospitalet de Llobregat

08017

Ophthalmology at Instituto Oftalmologico Integral, Barcelona

08036

Hospital Clinic Barcelona, Barcelona

08970

Hospital de Sant Joan Despi Moises Broggi, Barcelona

08907

Radiology at Hospital Univeristari de Bellvitge, L'Hospitalet de Llobregat

07198

Hospital Son Llatzer, Palma de Mallorca

171 76

Karolinska Universitetssjukhuset, Stockholm

751 85

Onkologkliniken Akademiska Sjukhuset, Uppsala

W1G 6AD

Sarah Cannon Research Institute UK, London

NG5 1PB

Nottingham University Hospitals NHS Trust, Nottingham

NG7 2UH

University of Nottingham, Nottingham

KT21 2SB

Ashtead Hospital, Ashtead

KT18 7LX

The Clock House Medical Practice, Epsom

SM2 5PT

The Royal Marsden NHS Foundation Trust, Sutton

SM3 9Dw

St. Anthony's Hospital, North Cheam

B18 7QH

City Hospital, Birmingham

SW3 6JJ

Royal Marsden NHS Foundation Trust, London

W1G 8PP

The Harley Street Clinic, London

W1G 9QN

London Eye Diagnostic Centre, London

M20 4BX

The Christie NHS Foundation Trust, Manchester

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY