42
Participants
Start Date
August 31, 2013
Primary Completion Date
June 30, 2015
Study Completion Date
June 30, 2015
Vastus Muscle Biopsy
Both Arms, all 3 visits at 0, 4 and 12 weeks
LOLA or placebo
Hepa-Merz Granulat 3000 Hepa-Merz granules 3g (Each 5g sachet contains 3g of L-ornithine L-aspartate) L-ornithine L-aspartate LOLA Randomised to a daily dose 18g per day, two sachets of Hepa-Merz granules three times a day (or placebo)for 12 weeks
Cognitive assessment (PHES)
Both Arms, all 3 visits at 0, 4 and 12 weeks
Cognitive Assessement (Cogstate)
Both Arms, all 3 visits at 0, 4 and 12 weeks
blood and urine sampling
Both Arms, all 3 visits at 0, 4 and 12 weeks
Nutritional assessment
Both Arms, all 3 visits at 0, 4 and 12 weeks
MRI brain and spectroscopy
Both Arms, all 3 visits at 0, 4 and 12 weeks
MRI leg cross section
Both Arms, all 3 visits at 0, 4 and 12 weeks
Functional MRI (working memory and attention tasks)
Both Arms, all 3 visits at 0, 4 and 12 weeks
Liver unit St Mary's Hospital, 10th floor QEQM Wing, South Wharf Road, London
Imperial College London
OTHER