NCT01836523View on ClinicalTrials.gov

The Efficacy and Safety of Liraglutide as Adjunct Therapy to Insulin in the Treatment of Type 1 Diabetes

PHASE3CompletedINTERVENTIONAL
Enrollment

1,398

Participants

Timeline

Start Date

November 30, 2013

Primary Completion Date

June 30, 2015

Study Completion Date

June 30, 2015

Conditions
DiabetesDiabetes Mellitus, Type 1
Interventions
DRUG

liraglutide

Subjects randomised to 0.6 mg liraglutide treatment or liraglutide placebo as an add-on to their pre-trial insulin treatment will remain on this dose throughout the study (52 weeks). Administered subcutaneously (s.c., under the skin) once daily.

DRUG

placebo

Subjects randomised to 0.6 mg liraglutide treatment or liraglutide placebo as an add-on to their pre-trial insulin treatment will remain on this dose throughout the study (52 weeks). Administered subcutaneously (s.c., under the skin) once daily.

DRUG

liraglutide

Subjects randomised to 0.6 mg liraglutide treatment or liraglutide placebo as an add-on to their pre-trial insulin treatment will remain on this dose throughout the study (52 weeks). Administered subcutaneously (s.c., under the skin) once daily.

DRUG

placebo

Subjects randomised to 0.6 mg liraglutide treatment or liraglutide placebo as an add-on to their pre-trial insulin treatment will remain on this dose throughout the study (52 weeks). Administered subcutaneously (s.c., under the skin) once daily.

DRUG

liraglutide

Subjects randomised to 0.6 mg liraglutide treatment or liraglutide placebo as an add-on to their pre-trial insulin treatment will remain on this dose throughout the study (52 weeks). Administered subcutaneously (s.c., under the skin) once daily.

DRUG

placebo

Subjects randomised to 0.6 mg liraglutide treatment or liraglutide placebo as an add-on to their pre-trial insulin treatment will remain on this dose throughout the study (52 weeks). Administered subcutaneously (s.c., under the skin) once daily.

Trial Locations (182)

1346

Novo Nordisk Investigational Site, Gjettum

1405

Novo Nordisk Investigational Site, Capital Federal

2226

Novo Nordisk Investigational Site, Kongsvinger

2292

Novo Nordisk Investigational Site, Broadmeadow

2318

Novo Nordisk Investigational Site, Hamar

2650

Novo Nordisk Investigational Site, Edegem

3000

Novo Nordisk Investigational Site, Leuven

3004

Novo Nordisk Investigational Site, Melbourne

3050

Novo Nordisk Investigational Site, Parkville

4000

Novo Nordisk Investigational Site, Liège

4011

Novo Nordisk Investigational Site, Stavanger

5021

Novo Nordisk Investigational Site, Bergen

5035

Novo Nordisk Investigational Site, Keswick

5112

Novo Nordisk Investigational Site, Elizabeth Vale

5500

Novo Nordisk Investigational Site, Mendoza

6700

Novo Nordisk Investigational Site, Arlon

10002

Novo Nordisk Investigational Site, Zhytomyr

10029

Novo Nordisk Investigational Site, New York

10032

Novo Nordisk Investigational Site, New York

10301

Novo Nordisk Investigational Site, Staten Island

11108

Novo Nordisk Investigational Site, Narbonne

11501

Novo Nordisk Investigational Site, Mineola

12206

Novo Nordisk Investigational Site, Albany

13210

Novo Nordisk Investigational Site, Syracuse

14033

Novo Nordisk Investigational Site, Caen

19082

Novo Nordisk Investigational Site, Upper Darby

21073

Novo Nordisk Investigational Site, Hamburg

21079

Novo Nordisk Investigational Site, Dijon

21229

Novo Nordisk Investigational Site, Baltimore

22607

Novo Nordisk Investigational Site, Hamburg

23510

Novo Nordisk Investigational Site, Norfolk

25030

Novo Nordisk Investigational Site, Besançon

27408

Novo Nordisk Investigational Site, Greensboro

28500

Novo Nordisk Investigational Site, Pori

28557

Novo Nordisk Investigational Site, Morehead City

29485

Novo Nordisk Investigational Site, Summerville

29572

Novo Nordisk Investigational Site, Myrtle Beach

29609

Novo Nordisk Investigational Site, Brest

29651

Novo Nordisk Investigational Site, Greer

30060

Novo Nordisk Investigational Site, Marietta

30076

Novo Nordisk Investigational Site, Roswell

30318

Novo Nordisk Investigational Site, Atlanta

31096

Novo Nordisk Investigational Site, Haifa

31405

Novo Nordisk Investigational Site, Savannah

32258

Novo Nordisk Investigational Site, Jacksonville

33012

Novo Nordisk Investigational Site, Hialeah

33312

Novo Nordisk Investigational Site, Fort Lauderdale

33520

Novo Nordisk Investigational Site, Tampere

33619

Novo Nordisk Investigational Site, Tampa

35039

Novo Nordisk Investigational Site, Marburg

35415

Novo Nordisk Investigational Site, Pohlheim

36011

Novo Nordisk Investigational Site, Poltava

37203

Novo Nordisk Investigational Site, Nashville

37212

Novo Nordisk Investigational Site, Nashville

37411

Novo Nordisk Investigational Site, Chattanooga

42270

Novo Nordisk Investigational Site, Saint-Priest-en-Jarez

44060

Novo Nordisk Investigational Site, Mentor

44800

Novo Nordisk Investigational Site, Saint-Herblain

45219

Novo Nordisk Investigational Site, Essen

46254

Novo Nordisk Investigational Site, Indianapolis

48145

Novo Nordisk Investigational Site, Münster

49202

Novo Nordisk Investigational Site, Petah Tikva

51501

Novo Nordisk Investigational Site, Council Bluffs

52242

Novo Nordisk Investigational Site, Iowa City

53209

Novo Nordisk Investigational Site, Milwaukee

53226

Novo Nordisk Investigational Site, Milwaukee

55416

Novo Nordisk Investigational Site, Minneapolis

58100

Novo Nordisk Investigational Site, Holon

59101

Novo Nordisk Investigational Site, Billings

59701

Novo Nordisk Investigational Site, Butte

60220

Novo Nordisk Investigational Site, Seinäjoki

60510

Novo Nordisk Investigational Site, Seinäjoki

61058

Novo Nordisk Investigational Site, Kharkiv

61070

Novo Nordisk Investigational Site, Kharkiv

63017

Novo Nordisk Investigational Site, Chesterfield

63303

Novo Nordisk Investigational Site, Saint Charles

63376

Novo Nordisk Investigational Site, City of Saint Peters

65807

Novo Nordisk Investigational Site, Springfield

66386

Novo Nordisk Investigational Site, Saint Ingbert

66606

Novo Nordisk Investigational Site, Topeka

66780

Novo Nordisk Investigational Site, Rehlingen-Siersburg

69200

Novo Nordisk Investigational Site, Vénissieux

70006

Novo Nordisk Investigational Site, Metarie

71200

Novo Nordisk Investigational Site, Le Creusot

72205

Novo Nordisk Investigational Site, Little Rock

75230

Novo Nordisk Investigational Site, Dallas

75231

Novo Nordisk Investigational Site, Dallas

75246

Novo Nordisk Investigational Site, Dallas

75650

Novo Nordisk Investigational Site, Rishon LeZiyyon

75877

Novo Nordisk Investigational Site, Paris

77478

Novo Nordisk Investigational Site, Sugar Land

78681

Novo Nordisk Investigational Site, Round Rock

79106

Novo Nordisk Investigational Site, Amarillo

79912

Novo Nordisk Investigational Site, El Paso

80209

Novo Nordisk Investigational Site, Denver

84102

Novo Nordisk Investigational Site, Salt Lake City

86000

Novo Nordisk Investigational Site, Poitiers

91106

Novo Nordisk Investigational Site, Corbeil-Essonnes

91120

Novo Nordisk Investigational Site, Jerusalem

91436

Novo Nordisk Investigational Site, Encino

91942

Novo Nordisk Investigational Site, La Mesa

92025

Novo Nordisk Investigational Site, Escondido

92648

Novo Nordisk Investigational Site, Huntington Beach

93106

Novo Nordisk Investigational Site, Jerusalem

93534

Novo Nordisk Investigational Site, Lancaster

93940

Novo Nordisk Investigational Site, Monterey

94401

Novo Nordisk Investigational Site, San Mateo

94520

Novo Nordisk Investigational Site, Concord

94583

Novo Nordisk Investigational Site, San Ramon

94598

Novo Nordisk Investigational Site, Walnut Creek

97159

Novo Nordisk Investigational Site, Pointe à Pitre

98003

Novo Nordisk Investigational Site, Federal Way

99208

Novo Nordisk Investigational Site, Spokane

99817

Novo Nordisk Investigational Site, Eisenach

400138

Novo Nordisk Investigational Site, Volgograd

410012

Novo Nordisk Investigational Site, Saratov

420012

Novo Nordisk Investigational Site, Kazan'

420073

Novo Nordisk Investigational Site, Kazan'

440026

Novo Nordisk Investigational Site, Penza

30308-2253

Novo Nordisk Investigational Site, Atlanta

83404-7596

Novo Nordisk Investigational Site, Idaho Falls

63110-1020

Novo Nordisk Investigational Site, St Louis

08648

Novo Nordisk Investigational Site, Lawrenceville

15224-2215

Novo Nordisk Investigational Site, Pittsburgh

37404-1192

Novo Nordisk Investigational Site, Chattanooga

38119-3821

Novo Nordisk Investigational Site, Memphis

05201

Novo Nordisk Investigational Site, Bennington

C1118AAT

Novo Nordisk Investigational Site, Caba

C1440AAD

Novo Nordisk Investigational Site, Caba

X5016KEH

Novo Nordisk Investigational Site, Córdoba

B1708IFF

Novo Nordisk Investigational Site, Morón

T6G 2E1

Novo Nordisk Investigational Site, Edmonton

R3E 3P4

Novo Nordisk Investigational Site, Winnipeg

L4M 7G1

Novo Nordisk Investigational Site, Barrie

N1R 7L6

Novo Nordisk Investigational Site, Cambridge

N6A 4V2

Novo Nordisk Investigational Site, London

L5M 2V8

Novo Nordisk Investigational Site, Mississauga

L6M 1M1

Novo Nordisk Investigational Site, Oakville

L4J 8L7

Novo Nordisk Investigational Site, Thornhill

M4G 3E8

Novo Nordisk Investigational Site, Toronto

M5C 2T2

Novo Nordisk Investigational Site, Toronto

M5T 3L9

Novo Nordisk Investigational Site, Toronto

H2W 1R7

Novo Nordisk Investigational Site, Montreal

G1V 4G2

Novo Nordisk Investigational Site, Québec

G1V 4G5

Novo Nordisk Investigational Site, Québec

J1G 5K2

Novo Nordisk Investigational Site, Sherbrooke

00029

Novo Nordisk Investigational Site, Helsinki

00250

Novo Nordisk Investigational Site, Helsinki

FI-20520

Novo Nordisk Investigational Site, Turku

06679

Novo Nordisk Investigational Site, Hohenmölsen

DUBLIN 15

Novo Nordisk Investigational Site, Dublin

DUBLIN 4

Novo Nordisk Investigational Site, Dublin

DUBLIN 7

Novo Nordisk Investigational Site, Dublin

Unknown

Novo Nordisk Investigational Site, Dublin

Novo Nordisk Investigational Site, Galway

1105 AZ

Novo Nordisk Investigational Site, Amsterdam

7909 AA

Novo Nordisk Investigational Site, Hoogeveen

2333 ZA

Novo Nordisk Investigational Site, Leiden

6525 GA

Novo Nordisk Investigational Site, Nijmegen

3011 TA

Novo Nordisk Investigational Site, Rotterdam

2512 VA

Novo Nordisk Investigational Site, The Hague

5912 BL

Novo Nordisk Investigational Site, Venlo

20-044

Novo Nordisk Investigational Site, Lublin

24-100

Novo Nordisk Investigational Site, Puławy

00-911

Novo Nordisk Investigational Site, Warsaw

03-242

Novo Nordisk Investigational Site, Warsaw

41-800

Novo Nordisk Investigational Site, Zabrze

413 45

Novo Nordisk Investigational Site, Gothenburg

205 02

Novo Nordisk Investigational Site, Malmo

112 81

Novo Nordisk Investigational Site, Stockholm

141 86

Novo Nordisk Investigational Site, Stockholm

04114

Novo Nordisk Investigational Site, Kiev

BB2 3HH

Novo Nordisk Investigational Site, Blackburn

BS10 5NB

Novo Nordisk Investigational Site, Bristol

DH11 5TW

Novo Nordisk Investigational Site, Durham

B15 2TH

Novo Nordisk Investigational Site, Edgbaston, Birmingham

EH4 2XU

Novo Nordisk Investigational Site, Edinburgh

TS4 3BW

Novo Nordisk Investigational Site, Middlesbrough

PL6 8BQ

Novo Nordisk Investigational Site, Plymouth

UB1 3HW

Novo Nordisk Investigational Site, Southall

WA9 3DA

Novo Nordisk Investigational Site, St Helens

SG1 4AB

Novo Nordisk Investigational Site, Stevenage

Sponsors

Lead Sponsor

Novo Nordisk A/S
All Listed Sponsors
lead

Novo Nordisk A/S

INDUSTRY