Cabozantinib-S-Malate Compared With Temozolomide or Dacarbazine in Treating Patients With Metastatic Melanoma of the Eye That Cannot Be Removed by Surgery

PHASE2CompletedINTERVENTIONAL
Enrollment

47

Participants

Timeline

Start Date

July 31, 2013

Primary Completion Date

October 21, 2016

Study Completion Date

November 1, 2019

Conditions
Recurrent Uveal MelanomaStage III Uveal Melanoma AJCC v7Stage IIIA Uveal Melanoma AJCC v7Stage IIIB Uveal Melanoma AJCC v7Stage IIIC Uveal Melanoma AJCC v7Stage IV Uveal Melanoma AJCC v7
Interventions
DRUG

Cabozantinib S-malate

Given PO

DRUG

Dacarbazine

Given IV

OTHER

Laboratory Biomarker Analysis

Correlative studies

DRUG

Temozolomide

Given PO

Trial Locations (228)

19104

University of Pennsylvania/Abramson Cancer Center, Philadelphia

19713

Christiana Gynecologic Oncology LLC, Newark

Delaware Clinical and Laboratory Physicians PA, Newark

Helen F Graham Cancer Center, Newark

Medical Oncology Hematology Consultants PA, Newark

19718

Christiana Care Health System-Christiana Hospital, Newark

19801

Christiana Care Health System-Wilmington Hospital, Wilmington

19958

Beebe Medical Center, Lewes

19971

Beebe Health Campus, Rehoboth Beach

19973

TidalHealth Nanticoke / Allen Cancer Center, Seaford

24273

Southwest VA Regional Cancer Center, Norton

27157

Wake Forest University Health Sciences, Winston-Salem

27710

Duke University Medical Center, Durham

28501

Vidant Oncology-Kinston, Kinston

29316

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29601

Greenville Health System Cancer Institute-Andrews, Greenville

29605

Prisma Health Cancer Institute - Butternut, Greenville

Prisma Health Cancer Institute - Faris, Greenville

Prisma Health Greenville Memorial Hospital, Greenville

29615

Prisma Health Cancer Institute - Eastside, Greenville

29640

Prisma Health Cancer Institute - Easley, Easley

29650

Prisma Health Cancer Institute - Greer, Greer

29672

Prisma Health Cancer Institute - Seneca, Seneca

33140

Mount Sinai Medical Center, Miami Beach

33308

Holy Cross Hospital, Fort Lauderdale

33458

Jupiter Medical Center, Jupiter

35233

University of Alabama at Birmingham Cancer Center, Birmingham

37604

Wellmont Medical Associates Oncology and Hematology-Johnson City, Johnson City

37620

Bristol Regional Medical Center, Bristol

37660

Ballad Health Cancer Care - Kingsport, Kingsport

Wellmont Holston Valley Hospital and Medical Center, Kingsport

43210

Ohio State University Comprehensive Cancer Center, Columbus

45219

The Christ Hospital, Cincinnati

49017

Bronson Battle Creek, Battle Creek

49085

Lakeland Medical Center Saint Joseph, Saint Joseph

Marie Yeager Cancer Center, Saint Joseph

49120

Lakeland Hospital Niles, Niles

49444

Mercy Health Mercy Campus, Muskegon

49503

Cancer Research Consortium of West Michigan NCORP, Grand Rapids

Mercy Health Saint Mary's, Grand Rapids

Spectrum Health at Butterworth Campus, Grand Rapids

49677

Spectrum Health Reed City Hospital, Reed City

49684

Munson Medical Center, Traverse City

49801

Green Bay Oncology - Iron Mountain, Iron Mountain

49829

Green Bay Oncology - Escanaba, Escanaba

50010

Mary Greeley Medical Center, Ames

McFarland Clinic PC - Ames, Ames

50036

McFarland Clinic PC-Boone, Boone

50129

McFarland Clinic PC-Jefferson, Jefferson

50158

McFarland Clinic PC-Marshalltown, Marshalltown

50501

McFarland Clinic PC-Trinity Cancer Center, Fort Dodge

51101

Siouxland Regional Cancer Center, Sioux City

51102

Mercy Medical Center-Sioux City, Sioux City

51104

Saint Luke's Regional Medical Center, Sioux City

52242

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

52722

Constantinou, Costas L MD (UIA Investigator), Bettendorf

53081

HSHS Saint Nicholas Hospital, Sheboygan

53226

Medical College of Wisconsin, Milwaukee

53792

University of Wisconsin Carbone Cancer Center, Madison

54017

Cancer Center of Western Wisconsin, New Richmond

54143

Bay Area Medical Center, Marinette

54154

Saint Vincent Hospital Cancer Center at Oconto Falls, Oconto Falls

54221

Holy Family Memorial Hospital, Manitowoc

54235

Green Bay Oncology - Sturgeon Bay, Sturgeon Bay

54301

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

54303

Green Bay Oncology Limited at Saint Mary's Hospital, Green Bay

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay

55082

Lakeview Hospital, Stillwater

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

Saint John's Hospital - Healtheast, Maplewood

55125

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

Fairview Ridges Hospital, Burnsville

55350

Hutchinson Area Health Care, Hutchinson

55379

Saint Francis Regional Medical Center, Shakopee

55387

Ridgeview Medical Center, Waconia

55407

Abbott-Northwestern Hospital, Minneapolis

55415

Hennepin County Medical Center, Minneapolis

55416

Metro Minnesota Community Oncology Research Consortium, Saint Louis Park

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

North Memorial Medical Health Center, Robbinsdale

55432

Unity Hospital, Fridley

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55454

Health Partners Inc, Minneapolis

55805

Essentia Health Cancer Center, Duluth

Essentia Health Saint Mary's Medical Center, Duluth

Miller-Dwan Hospital, Duluth

55905

Mayo Clinic in Rochester, Rochester

56073

New Ulm Medical Center, New Ulm

56201

Rice Memorial Hospital, Willmar

59101

Billings Clinic Cancer Center, Billings

Saint Vincent Healthcare, Billings

59102

Montana Cancer Consortium NCORP, Billings

59405

Benefis Healthcare- Sletten Cancer Institute, Great Falls

Great Falls Clinic, Great Falls

59601

Saint Peter's Community Hospital, Helena

59701

Saint James Community Hospital and Cancer Treatment Center, Butte

59711

Community Hospital of Anaconda, Anaconda

59715

Bozeman Deaconess Hospital, Bozeman

59802

Saint Patrick Hospital - Community Hospital, Missoula

59804

Community Medical Hospital, Missoula

59901

Kalispell Regional Medical Center, Kalispell

60035

Hematology Oncology Associates of Illinois-Highland Park, Highland Park

60048

AMG Libertyville - Oncology, Libertyville

60076

Hematology Oncology Associates of Illinois - Skokie, Skokie

60153

Loyola University Medical Center, Maywood

60611

Northwestern University, Chicago

60637

University of Chicago Comprehensive Cancer Center, Chicago

60714

Illinois Cancer Specialists-Niles, Niles

60901

Presence Saint Mary's Hospital, Kankakee

61265

Garneau, Stewart C MD (UIA Investigator), Moline

Porubcin, Michael MD (UIA Investigator), Moline

Spector, David MD (UIA Investigator), Moline

Trinity Medical Center, Moline

62864

Good Samaritan Regional Health Center, Mount Vernon

63109

Saint Louis Cancer and Breast Institute-South City, St Louis

63141

Mercy Hospital Saint Louis, St Louis

64057

Centerpoint Medical Center LLC, Independence

64068

Liberty Radiation Oncology Center, Liberty

64086

Saint Luke's East - Lee's Summit, Lee's Summit

64111

Saint Luke's Hospital of Kansas City, Kansas City

64118

Heartland Hematology and Oncology Associates Incorporated, Kansas City

64132

Research Medical Center, Kansas City

64506

Heartland Regional Medical Center, Saint Joseph

64507

Saint Joseph Oncology Inc, Saint Joseph

64804

Mercy Hospital Joplin, Joplin

65401

Mercy Clinic-Rolla-Cancer and Hematology, Rolla

65616

Cox Cancer Center Branson, Branson

65804

Cancer Research for the Ozarks NCORP, Springfield

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

66208

Kansas City NCI Community Oncology Research Program, Prairie Village

66209

Menorah Medical Center, Overland Park

66213

Saint Luke's South Hospital, Overland Park

68114

Nebraska Methodist Hospital, Omaha

68198

University of Nebraska Medical Center, Omaha

73104

University of Oklahoma Health Sciences Center, Oklahoma City

74146

Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa

75390

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

82414

Big Horn Basin Cancer Center, Cody

Billings Clinic-Cody, Cody

82609

Rocky Mountain Oncology, Casper

82801

Welch Cancer Center, Sheridan

83301

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Saint Luke's Cancer Institute - Meridian, Meridian

83686

Saint Luke's Cancer Institute - Nampa, Nampa

83712

Saint Luke's Cancer Institute - Boise, Boise

83814

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

Kootenai Cancer Clinic, Sandpoint

89052

Cancer and Blood Specialists-Henderson, Henderson

Comprehensive Cancer Centers of Nevada - Henderson, Henderson

Las Vegas Cancer Center-Henderson, Henderson

89074

Comprehensive Cancer Centers of Nevada-Southeast Henderson, Henderson

GenesisCare USA - Henderson, Henderson

89102

University Medical Center of Southern Nevada, Las Vegas

89106

Cancer and Blood Specialists-Shadow, Las Vegas

Radiation Oncology Centers of Nevada Central, Las Vegas

89109

GenesisCare USA - Las Vegas, Las Vegas

HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway, Las Vegas

89113

HealthCare Partners Medical Group Oncology/Hematology-San Martin, Las Vegas

89119

Radiation Oncology Centers of Nevada Southeast, Las Vegas

89121

Cancer Therapy and Integrative Medicine, Las Vegas

89128

Cancer and Blood Specialists-Tenaya, Las Vegas

Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas

GenesisCare USA - Vegas Tenaya, Las Vegas

HealthCare Partners Medical Group Oncology/Hematology-Tenaya, Las Vegas

89144

Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas

89148

Comprehensive Cancer Centers of Nevada, Las Vegas

GenesisCare USA - Fort Apache, Las Vegas

OptumCare Cancer Care at Fort Apache, Las Vegas

89149

HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills, Las Vegas

89169

Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas

Nevada Cancer Research Foundation NCORP, Las Vegas

91505

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank

97015

Clackamas Radiation Oncology Center, Clackamas

Providence Cancer Institute Clackamas Clinic, Clackamas

97045

Providence Willamette Falls Medical Center, Oregon City

97132

Providence Newberg Medical Center, Newberg

97213

Providence Portland Medical Center, Portland

97222

Providence Milwaukie Hospital, Milwaukie

97225

Providence Saint Vincent Medical Center, Portland

97420

Bay Area Hospital, Coos Bay

97701

Saint Charles Health System, Bend

98005

Swedish Cancer Institute-Eastside Oncology Hematology, Bellevue

98026

Swedish Cancer Institute-Edmonds, Edmonds

98029

Swedish Cancer Institute-Issaquah, Issaquah

98104

Minor and James Medical PLLC, Seattle

Pacific Gynecology Specialists, Seattle

98107

Swedish Medical Center-Ballard Campus, Seattle

98112

Kaiser Permanente Washington, Seattle

98201

Providence Regional Cancer Partnership, Everett

98221

Cancer Care Center at Island Hospital, Anacortes

98225

PeaceHealth Saint Joseph Medical Center, Bellingham

98503

Providence Regional Cancer System-Lacey, Lacey

98520

Providence Regional Cancer System-Aberdeen, Aberdeen

98531

Providence Regional Cancer System-Centralia, Centralia

98584

Providence Regional Cancer System-Shelton, Shelton

98597

Providence Regional Cancer System-Yelm, Yelm

98632

PeaceHealth Saint John Medical Center, Longview

98664

PeaceHealth Southwest Medical Center, Vancouver

98684

Compass Oncology Vancouver, Vancouver

98902

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital, Yakima

99204

MultiCare Deaconess Cancer and Blood Specialty Center - Downtown, Spokane

99216

MultiCare Deaconess Cancer and Blood Specialty Center - Valley, Spokane Valley

99362

Providence Saint Mary Regional Cancer Center, Walla Walla

99504

Anchorage Radiation Therapy Center, Anchorage

99508

Alaska Breast Care and Surgery LLC, Anchorage

Alaska Oncology and Hematology LLC, Anchorage

Alaska Women's Cancer Care, Anchorage

Anchorage Oncology Centre, Anchorage

Katmai Oncology Group, Anchorage

Providence Alaska Medical Center, Anchorage

02114

Massachusetts General Hospital Cancer Center, Boston

02115

Brigham and Women's Hospital, Boston

02215

Dana-Farber Cancer Institute, Boston

89148-2405

Las Vegas Cancer Center-Medical Center, Las Vegas

07960

Morristown Medical Center, Morristown

07902

Overlook Hospital, Summit

98122-4307

Swedish Medical Center-First Hill, Seattle

54301-3526

Green Bay Oncology at Saint Vincent Hospital, Green Bay

T6G 1Z2

Cross Cancer Institute, Edmonton

M5G 2M9

University Health Network-Princess Margaret Hospital, Toronto

H2L 4M1

CHUM - Hopital Notre-Dame, Montreal

S7N 4H4

Saskatoon Cancer Centre, Saskatoon

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Exelisis

UNKNOWN

lead

National Cancer Institute (NCI)

NIH

NCT01835145 - Cabozantinib-S-Malate Compared With Temozolomide or Dacarbazine in Treating Patients With Metastatic Melanoma of the Eye That Cannot Be Removed by Surgery | Biotech Hunter | Biotech Hunter